The immune tissues of the endangered red‐tailed phascogale (<i>Phascogale calura</i>)

Old, Julie M.; Carman, Rebecca L.; Fry, Gary C.; Deane, Elizabeth M.

doi:10.1111/j.1469-7580.2006.00530.x

Cited by 15 publications

(15 citation statements)

References 25 publications

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“…The primary lymphoid tissues, namely, the thymus and bone marrow, reached maturity before the secondary lymphoid tissues including the lymph nodes, spleen, liver, and GALT. By the end of pouch life, the spleen, liver, and GALT were histologically comparable with that previously described in juveniles and adults of this species (Old et al, ). Unlike the adult phascogales examined previously, no pouch young examined here demonstrated any BALT.…”

Section: Discussionsupporting

confidence: 84%

“…Some immune tissues from juvenile and adult red‐tailed phascogales ( Phascogale calura ) have previously been examined using both histology and immunohistochemistry by Old et al (). However, only the spleen, liver, GALT, and bronchus‐associated lymphoid tissue (BALT) were examined, and the thymus, bone marrow, and lymph nodes in this species were not examined.…”

Section: Introductionmentioning

confidence: 99%

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Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Borthwick

Old

2015

The Anatomical Record

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Red-tailed phascogale (Phascogale calura) pouch young at birth were relatively underdeveloped in comparison with their eutherian counterparts, and the lymphoid tissues of the immune system were found to be histologically immature. The phascogale thymus rapidly developed in the first few days of pouch life and was quickly populated with lymphocytes. By the end of pouch life, involution of the thymus was underway. The bone marrow started to develop in the early stage of pouch life, although adipocytes and megakaryocytes were not observed until slightly later. The liver was hematopoietic from birth and reached histological maturity toward the end of pouch life. The lymph nodes were difficult to detect macroscopically because of their small size, but were easily identified microscopically later in pouch life, particularly in the mesentery, and these lymph nodes exhibited germinal centers by the end of pouch life. The early spleen was predominately mesenchymal, but exhibited some erythropoiesis. Follicles with well-developed germinal centers were not observed until the latest stage of pouch life. Although intraepithelial lymphocytes were detected in the intestines early in pouch life, the discrete lymphoid aggregates and Peyer's patches characteristic of the gut-associated lymphoid tissue (GALT) were not detected until later in pouch life. This is the first report of histological development in phascogale pouch young, as well as the first report of the thymus, bone marrow, and lymph nodes in this dasyurid species at any age. Anat Rec, 299:207-219, 2016. V C 2015 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Borthwick

Old

2015

The Anatomical Record

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“…However, there remains a lack of basic knowledge about the cellular components and histological architecture of the lymphoid organs of this species. Descriptions of the lymphoid tissues of four small Dasyurids, the brown and dusky antechinus (Antechinus swainsonii and A. stuartii), the stripe-faced dunnart (Sminthopsis macroura), and the red-tailed phascogale (Phascogale calura), have been published (Poskitt et al, 1984a,b,c;Old et al, 2003Old et al, , 2004Old et al, , 2006 and provide important data about this group. Basic information about the immune tissues of the Tasmanian devil, however, is required to better understand the adaptive immune response and its implications for the pathogenesis of DFTD.…”

mentioning

confidence: 99%

A Histological and Immunohistochemical Analysis of Lymphoid Tissues of the Tasmanian Devil

Kreiss

Obendorf

Hemsley

et al. 2009

The Anatomical Record

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Tasmanian devil lymphoid tissues (thymus, spleen, and lymph node) from seven animals, including pouch young, juvenile, and adult devils, were investigated using histological and immunohistochemical techniques. Antibodies against the conserved intracytoplasmic portion of CD3 and CD79b (T-and B-cell markers, respectively) and MHC II were used to label immune cells. The thymus from the juvenile devils and the pouch young had CD3þ cells that were primarily located in the medulla of the organ. The spleen consisted of red and white pulp areas with characteristic lymphoid follicles with CD79bþ and MHC IIþ cells and nonfollicular T-cell-dominated periarteriolar lymphoid sheaths. Peripheral lymph nodes presented three distinct regions, outer cortex and medulla (both with primarily CD79bþ and MHC IIþ cells) and paracortex (mainly CD3þ cells). Tissue architecture and distribution of the immune cells were similar to that seen in eutherian mammals and other marsupials, indicating that the Tasmanian devil has all the structural elements necessary for effective adaptive immunity. Anat Rec, 292:611-620, 2009. V V C 2009 Wiley-Liss, Inc.

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“…However, there remains a lack of basic knowledge about the cellular components and histological architecture of the lymphoid organs of this species. Descriptions of the lymphoid tissues of four small Dasyurids, the brown and dusky antechinus ( Antechinus swainsonii and A. stuartii ), the stripe‐faced dunnart ( Sminthopsis macroura ), and the red‐tailed phascogale ( Phascogale calura ), have been published (Poskitt et al,1984a,b,c; Old et al,2003,2004,2006) and provide important data about this group. Basic information about the immune tissues of the Tasmanian devil, however, is required to better understand the adaptive immune response and its implications for the pathogenesis of DFTD.…”

mentioning

confidence: 99%

Detection of recurrence in childhood solid tumors

Howell¹,

Mensah²,

Brennan³

et al. 2005

Cancer

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Tasmanian devil lymphoid tissues (thymus, spleen, and lymph node) from seven animals, including pouch young, juvenile, and adult devils, were investigated using histological and immunohistochemical techniques. Antibodies against the conserved intracytoplasmic portion of CD3 and CD79b (T‐ and B‐cell markers, respectively) and MHC II were used to label immune cells. The thymus from the juvenile devils and the pouch young had CD3+ cells that were primarily located in the medulla of the organ. The spleen consisted of red and white pulp areas with characteristic lymphoid follicles with CD79b+ and MHC II+ cells and nonfollicular T‐cell‐dominated periarteriolar lymphoid sheaths. Peripheral lymph nodes presented three distinct regions, outer cortex and medulla (both with primarily CD79b+ and MHC II+ cells) and paracortex (mainly CD3+ cells). Tissue architecture and distribution of the immune cells were similar to that seen in eutherian mammals and other marsupials, indicating that the Tasmanian devil has all the structural elements necessary for effective adaptive immunity. Anat Rec, 292:611–620, 2009. © 2009 Wiley‐Liss, Inc.

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The immune tissues of the endangered red‐tailed phascogale (Phascogale calura)

Cited by 15 publications

References 25 publications

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

Histological Development of the Immune Tissues of a Marsupial, the Red‐Tailed Phascogale (Phascogale calura)

A Histological and Immunohistochemical Analysis of Lymphoid Tissues of the Tasmanian Devil

Detection of recurrence in childhood solid tumors

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