Phaeochromocytoma is a rare clinical entity in children. Contrary to traditional teaching, which suggested that 10% of phaeochromocytomas are "familial", a germline mutation has been identified in up to 59% (27/48) of apparently sporadic phaeochromocytomas presenting at 18 years or younger and in 70% of those presenting before 10 years of age. The inherited predisposition may be attributable to a germline mutation in the Von Hippel-Lindau gene, the genes encoding the subunits B and D of succinate dehydrogenase, the RET proto-oncogene predisposing to multiple endocrine neoplasia type 2, or the neurofibromatosis type 1 gene. Of these, the Von Hippel-Lindau gene is the most commonly mutated gene in children presenting with a phaeochromocytoma. Genetic counselling is recommended before gene testing and investigation of the wider family. This review provides guidance on the aetiology, investigation, management, histopathology, genetics and follow-up of children with a phaeochromocytoma.

This pilot study examines the efficacy of a group memory notebook intervention. Five individuals with very mild dementia and 4 spouses who served as coaches attended 14 group treatment sessions. Therapists use educational strategies and learning activities packets to teach memory notebook use. At posttreatment, coaches report fewer symptoms of depression, and participants with very mild dementia report greater confidence in ability to obtain support. Modified laboratory memory testing reveals that participants with dementia demonstrate improved posttreatment memory scores because of increased note-taking behavior and more frequent referencing of notes. Although more frequent everyday memory strategies use is reported at posttreatment, this does not translate into reports of fewer everyday memory failures or greater everyday independence for the participants with dementia. This study demonstrates that a multidyad group intervention can successfully be used to teach patients with very mild dementia to use a memory notebook, with beneficial effects for both members of the care dyad.

One of the most important tasks faced by adolescents and young adults is the formation of romantic relationships. Little is known, however, about the developmental timing of early relational experiences. This study investigated the age at which an ethnically diverse sample of young adults (N = 683) experienced their very first date, love, serious relationship, kiss, and act of intercourse. Most had experienced each event by the end of high school, with first dates and kisses occurring at earlier ages than falling in love or intercourse. Gender and ethnic differences were found. For example, young men began dating at earlier ages than did young women. Asian American participants were less sexually and romantically experienced, and had their very first sexual experiences at an older age, than African American, Latino/Hispanic, and Caucasian/non-Hispanic White participants. Interestingly, there were no differences in first romantic love experience. Almost all men and women within each ethnic group had fallen in love at least once, typically around age 17; this suggests that romantic love is a common human life event and that it first occurs during the developmental period spanning late adolescence and early adulthood.

management, Parents of kids with cancer initiative of the Saarland (Elterninitiative Krebskranker Kinder im Saarland e.V., Germany) for continuous data management of GPOH-centres.We thank all of the clinicians and families who participated in this study at all centers across 28 countries and all of the national childhood cancer groups for their support, in particular the Société Française des Cancers de l'Enfant (SFCE), Gesellschaft fur Paediatrische Onkologie und Haematologie (GPOH), Children's Cancer and Leukemia Group (CCLG), Spanish

Tasmanian devil lymphoid tissues (thymus, spleen, and lymph node) from seven animals, including pouch young, juvenile, and adult devils, were investigated using histological and immunohistochemical techniques. Antibodies against the conserved intracytoplasmic portion of CD3 and CD79b (T‐ and B‐cell markers, respectively) and MHC II were used to label immune cells. The thymus from the juvenile devils and the pouch young had CD3+ cells that were primarily located in the medulla of the organ. The spleen consisted of red and white pulp areas with characteristic lymphoid follicles with CD79b+ and MHC II+ cells and nonfollicular T‐cell‐dominated periarteriolar lymphoid sheaths. Peripheral lymph nodes presented three distinct regions, outer cortex and medulla (both with primarily CD79b+ and MHC II+ cells) and paracortex (mainly CD3+ cells). Tissue architecture and distribution of the immune cells were similar to that seen in eutherian mammals and other marsupials, indicating that the Tasmanian devil has all the structural elements necessary for effective adaptive immunity. Anat Rec, 292:611–620, 2009. © 2009 Wiley‐Liss, Inc.