The Immune Response

Wakelin, D.; Denham, D. A.

doi:10.1007/978-1-4613-3578-8_8

Cited by 85 publications

(31 citation statements)

References 97 publications

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“…The higher susceptibility of the European eel, in comparison to the native Japanese host eel (in terms of prevalence or histopathological damages, see Egusa 1979, Nagasawa et al 1994) is thus assumed to result from a lower immune competence (Nielsen 1999). Typically, immuno-competence may only be acquired after long periods of parasite-host coevolution (Wakelin 1996), which is not the case here. However, the possibility of host adaptation in explaining the stabilization of the infection cannot be excluded.…”

Section: Discussionmentioning

confidence: 90%

Anguillicolosis: dynamics of the infection over two decades

Lefebvre¹,

Crivellì²

2004

Dis. Aquat. Org.

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The dynamics of the infection of the European eel Anguilla anguilla L. by the Asian nematode Anguillicola crassus Kuwahara, Niimi and Itagaki, 1974 (i.e. anguillicolosis) was monitored over 2 decades in an oligohaline canal in southern France (Camargue, Mediterranean coast). Since the first mention of the parasite in this canal in 1985, which was also the first record in France, prevalence of pre-adult and adult forms has risen from 32 to 73%. However, during the last 7 yr (1997 to 2003), prevalence seems to have stabilized around values of 60 to 70% and parasite load, though inter-annual variation is substantial, shows no sign of increase (intensity for the last 5 yr: min. = 3.70, max. = 9.66, mean = 6.01). Our results thus confirm the dynamic pattern observed elsewhere in Europe, i.e. a rapid spread following the introduction of the parasite in a water system and then stabilization around ceiling levels. We review possible mechanisms that may explain such a leveling off in the infection spread. We particularly document the possibility that repetitive infections may render the infected organ, i.e. the swimbladder, unsuitable for further A. crassus establishment. In support of this hypothesis, we showed that the infection rate is lower among eels with severely damaged swimbladders.

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Section: Discussionmentioning

confidence: 90%

Anguillicolosis: dynamics of the infection over two decades

Lefebvre¹,

Crivellì²

2004

Dis. Aquat. Org.

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“…Correlation between antibody responses and protection have been established by passive transfer experiments following immunisation by L1 extracts (Robinson et al 1995a) or by protection against secondary infections either in rats (Wakelin and Denham 1983, Appleton and McGregor 1984, Bell 1992a or in mice (Bell 1992b). Among isotypes the IgG1 subclass appears to play the most important role in protective responses McGregor 1987, Robinson et al 1995b).…”

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confidence: 99%

Dynamics of the IgG3 responses following immunisation of BALB/c mice with somatic and excretory/secretory antigens from various Trichinella species

Dea-Ayuela¹,

Bolás‐Fernández²

2000

FOLIA PARASIT

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Abstract.Comparison of the dynamics and antigen recognition profiles of IgG3 following immunisation with larval crude extracts (LCE) and excretory-secretory (ES) products from muscle larvae of different species of Trichinella (T. spiralis, T. nativa, T. britovi, T. nelsoni and genotype T6) was made in BALB/c mice. High levels of IgG3 response were obtained in ELISA following immunisation with LCE from all species with maximum levels achieved between days 59 and 64 post-immunisation (p.i.) and maintained up to the limit of the observation (day 164). Antigen recognition profiles as measured by western-blot showed dense and numerous bands in the range 45-64 kDa that were consistent from week 5 th with variation in epitope recognition among the different species. Following immunisation with ES antigens a significant decrease in IgG3 response was observed for all species especially for T. nativa in comparison to LCE. Antigen recognition on ES antigens showed three main bands in the range of 45-60 kDa for all species excepting T. nelsoni and T. britovi where an additional band was also present. These results clearly show that IgG3 epitopes are more abundant in somatic (LCE) than in ES products of Trichinella muscle larvae and that quantitative as well as qualitative variations exist among different species.

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“…Il est constamment précédé d'altérations structurelles des vers et associé à une inflammation importante de l'intestin (Genta et Ward, 1980 ;Mimori et coll., 1982 ;Nawa et Korenaga, 1983 ;Oison et Schiller, 1978a). Les altérations ne suffiraient pas pour provoquer le dépara sitage comme le montrent les expériences de transplantation des vers lésés (Wakelin et Denham, 1983 ;Kozar et coll., 1971 ;Dinetta et coll., 1972 ;Machnicka, 1972 ;Walls et coll., 1973 ;Gore et coll., 1974 ;Ruitenberg et Sterrenberg, 1974 ;Ogilvie et Worms, 1976, Manson-Smith et coll., 1979Perrudet-Badoux, 1980). Par contre, si les vers, avant d'être lésés, sont transférés dans un intestin où l'inflammation est importante, ils sont éliminés en même temps que les vers ayant provoqué cet état (Wakelin et Denham, 1983).…”

Section: Discussionunclassified

Rôle de l’inflammation dans le déparasitage spontané deStrongyloides ratti

Bailenger

Lacassie

1986

Ann. Parasitol. Hum. Comp.

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RÉSU M É. Pour établir le rôle de l'inflammation et de ses composants dans le déparasitage spon tané de Strongyloides ratti, les rats sont traités par des anti-inflammatoires non-stéroïdiens (indométacine, salicylate de sodium) ou par des antagonistes de certains médiateurs (dexchlorphéni-ramine, cyproheptadine, prométhazine). Les résultats sont comparés à ceux obtenus avec des traitements similaires de rats parasités par des Nématodes donnant également lieu à des phéno mènes de déparasitage spontané : Trichinella spiralis, notamment, mais aussi Nippostrongylus brasiliensis. Une coordination des différentes interprétations permet d'envisager un schéma qui rend compte du déroulement des réactions qui conduisent au rejet du parasite.The role of inflammation in spontaneous cure of Strongyloides ratti infestation SUM M ARY. In order to assess the role of inflammation and its components in spontaneous cure of Strongyloides ratti infestation, rats were treated with non-steroid anti-inflammatory agents (indometacin ; sodium salicylate) or with antagonists of certain mediators (dexchlorpheniramin ; cyproheptadin, promethazin). Results were compared with those obtained in similar treatments of rats infested by other Nematoda which also give rise to spontaneous cure : especially Trichinella spiralis, and Nippostron gylus brasiliensis. Coordinating the various findings made it possible to devise a pattern accounting for the chain of reactions that lead to rejection of the parasite.

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The Immune Response

Cited by 85 publications

References 97 publications

Anguillicolosis: dynamics of the infection over two decades

Anguillicolosis: dynamics of the infection over two decades

Dynamics of the IgG3 responses following immunisation of BALB/c mice with somatic and excretory/secretory antigens from various Trichinella species

Rôle de l’inflammation dans le déparasitage spontané deStrongyloides ratti

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