The Immune Response to Ehrlichia chaffeensis

Brouqui, Philippe; Dumler, J. Stephen

doi:10.1007/0-306-46804-2_10

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Killing of intracellular bacteria like E. canis by monocytes involves both oxygendependent and oxygen-independent mechanisms. However, it was hypothesized that oxidative stress plays only a minor role in killing of intracellular ehrlichiae and hence ROS production is not enhanced significantly [38]. GSH, a first line endogenous antioxidant defense can effectively neutralize free radicals either directly or indirectly through enzymatic reactions and protects cells from oxidative damage [39].…”

Section: Oxidant/antioxidant Status In Affected Animalsmentioning

confidence: 99%

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

Behera¹,

Dimri

Banerjee

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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The present study was aimed at detecting natural cases of canine monocytic ehrlichiosis (CME) by molecular and cytological methods and assessment of clinico-patho-biochemical parameters among the affected population. Nested polymerase chain reaction was found to be highly sensitive (47.7 %) in detecting the acute cases, followed by buffy coat (29.5 %) and blood smear examination (22.7 %). CME incidence rate was found to be 8.4 %. Hemogram revealed significant (P \ 0.01) depletion in the levels of hemoglobin, hematocrit, total erythrocyte count, monocyte and platelet count in diseased dogs as compared to healthy controls. Plasma biochemistry revealed hypoproteinemia, hypoalbuminemia and hyperglobulinemia along with significantly (P \ 0.05) higher blood urea nitrogen and alanine aminotransferase values. CME revealed non-significant increase in the levels of erythrocytic lipid peroxides, reduced glutathione and activity of superoxide dismutase, whereas activities of glutathione-S-transferase and glutathione reductase showed significant (P \ 0.05) increase and decrease, respectively as compared to healthy controls. Plasma levels of cortisol, insulin and blood level of copper showed non-significant (P [ 0.05) reduction, whereas blood level of zinc showed significant (P \ 0.05) reduction as compared to healthy controls. These findings revealed that changes in erythrocytic oxidant-antioxidant profile and blood mineral concentration in canine monocytic ehrlichiosis are largely nonsignificant and inconsistent. Hence, further study is required to elucidate their role in pathogenesis of canine monocytic ehrlichiosis.

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Section: Oxidant/antioxidant Status In Affected Animalsmentioning

confidence: 99%

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

Behera¹,

Dimri

Banerjee

et al. 2015

Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci.

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“…Chronic immunosuppression induced by different pathogens may predispose dogs to secondary infections, as has been observed in leishmaniosis, bartonellosis and ehrlichiosis (Bourdoiseau and others 1997, Brouqui and Dumler 1997, Waner and others 1998, Pappalardo and others 2000). In addition, the immunosuppressive effects may exacerbate the disease, because some of the pathological and clinical signs are immune mediated.…”

mentioning

confidence: 99%

PCR survey of vectorborne pathogens in dogs living in and around Barcelona, an area endemic for leishmaniosis

et al. 2009

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Blood samples from 153 dogs living in and around Barcelona were assayed for Leishmania infantum and Ehrlichia, Anaplasma, Rickettsia, Bartonella, Hepatozoon, Babesia and Theileria species by PCR amplification of DNA, and the amplicons obtained were sequenced. The prevalence of the infectious agents was L infantum (29.4 per cent), Ehrlichia and Anaplasma species (4.0 per cent), Hepatozoon canis (3.3 per cent), Babesia canis vogeli (2.0 per cent), Babesia gibsoni (2.0 per cent), Babesia canis canis (1.3 per cent) and Theileria annae (0.7 per cent). Coinfections were present in seven of the dogs and they were significantly associated with L infantum infection (P=0.024). There was a significant correlation between clinical signs of illness and the load of L infantum.

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“…Hemoplasmas in dogs Ehrlichiae of the family Anaplasmataceae (E. canis, are M. haemocanis, Candidatus M. haematoparvum E.chaffeensis, A. platys and A. phagocytophilum) are (Nascimento et al, 2012). Mycoplasma haemofelis, similar (Brouqui and Dumler, 2002). Polyclonal Candidatus Mycoplasma haemominutum, Candidatus hypergammaglobulinemia comprising IgM and IgA Mycoplasma turicensis cause feline infectious anemia in appear in 2-7 days, and shift to IgG by two weeks postthe presence of retrovirus-induced immunosuppression or infection (Iqbal et al, 1994;Weisiger et al, 1975).…”

mentioning

confidence: 99%

Complex clinical presentations of tick-borne diseases in dogs in Sri Lanka

Silva¹

2017

Sri Lanka Vet. J.

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The Immune Response to Ehrlichia chaffeensis

Cited by 5 publications

References 39 publications

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

Molecular Detection and Assessment of Hemato-Biochemistry, Oxidant/Antioxidant Status in Natural Canine Monocytic Ehrlichiosis Cases from Northern India

PCR survey of vectorborne pathogens in dogs living in and around Barcelona, an area endemic for leishmaniosis

Complex clinical presentations of tick-borne diseases in dogs in Sri Lanka

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