The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering

Yang, Dawei; Xiao, Jingyi; Wang, Beiyu; Li, Lang; Kong, Xiangli; Liao, Jinfeng

doi:10.1016/j.msec.2019.109927

Cited by 126 publications

(100 citation statements)

References 242 publications

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“…These polymers exhibit controllable degradation properties and can be fabricated to desired shapes. In the case of synthetic polymers, the most used include polyglycolic acid, polylactic acid, polylactic-co-glycolic acid, polycaprolactone, and polyvinyl alcohol [28].…”

Section: D-printing By Fused Deposition Modeling (Fdm)mentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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The regenerative medicine field is seeking novel strategies for the production of synthetic scaffolds that are able to promote the in vivo regeneration of a fully functional tissue. The choices of the scaffold formulation and the manufacturing method are crucial to determine the rate of success of the graft for the intended tissue regeneration process. On one hand, the incorporation of bioactive compounds such as growth factors and drugs in the scaffolds can efficiently guide and promote the spreading, differentiation, growth, and proliferation of cells as well as alleviate post-surgical complications such as foreign body responses and infections. On the other hand, the manufacturing method will determine the feasible morphological properties of the scaffolds and, in certain cases, it can compromise their biocompatibility. In the case of medicated scaffolds, the manufacturing method has also a key effect in the incorporation yield and retained activity of the loaded bioactive agents. In this work, solvent-free methods for scaffolds production, i.e., technological approaches leading to the processing of the porous material with no use of solvents, are presented as advantageous solutions for the processing of medicated scaffolds in terms of efficiency and versatility. The principles of these solvent-free technologies (melt molding, 3D printing by fused deposition modeling, sintering of solid microspheres, gas foaming, and compressed CO2 and supercritical CO2-assisted foaming), a critical discussion of advantages and limitations, as well as selected examples for regenerative medicine purposes are herein presented.

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Section: D-printing By Fused Deposition Modeling (Fdm)mentioning

confidence: 99%

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

2020

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“…[208] Finally, scaffolds and degradation products must be biocompatible and promote selective cell and protein adhesion, while inhibiting the onset of biofouling (Figure 10). [209] Tissue engineering scaffolds can be assembled in a multitude of approaches. Gel formation mechanisms dictate how cells and other biomolecules are incorporated into the biological environment to regenerate tissue.…”

Section: Intelligent Biomaterials For Tissue Engineering In Autoimmunmentioning

confidence: 99%

Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases

Shodeinde

Murphy

Oldenkamp

et al. 2020

Adv Funct Materials

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Autoimmune diseases are a group of debilitating illnesses that are often idiopathic in nature. The steady rise in the prevalence of these conditions warrants new approaches for diagnosis and treatment. Stimuli‐responsive biomaterials also known as “smart,” “intelligent,” or “recognitive” biomaterials are widely studied for their applications in drug delivery, biosensing, and tissue engineering due to their ability to produce thermal, optical, chemical, or structural changes upon interacting with the biological environment. Studies within the last decade that harness the recognitive capabilities of these biomaterials toward the development of novel detection and treatment options for autoimmune diseases are critically analyzed.

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“…An even more compelling point in favor of 3D-bioprinted constructs is represented by the attainment of biomimicry and hence the possibility of avoiding an abnormal immune reaction towards grafts, the well-known foreign body reaction, which may lead to chronic inflammation, fibrosis, or scarring and transplantation failure [ 16 , 17 ]. Indeed, according to the different physical, chemical, and biological properties, the various scaffolds used for bone implants can exhibit different immune responses.…”

Section: Introductionmentioning

confidence: 99%

Advances on Bone Substitutes through 3D Bioprinting

Genova

Roato

Carossa

et al. 2020

IJMS

101

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Reconstruction of bony defects is challenging when conventional grafting methods are used because of their intrinsic limitations (biological cost and/or biological properties). Bone regeneration techniques are rapidly evolving since the introduction of three-dimensional (3D) bioprinting. Bone tissue engineering is a branch of regenerative medicine that aims to find new solutions to treat bone defects, which can be repaired by 3D printed living tissues. Its aim is to overcome the limitations of conventional treatment options by improving osteoinduction and osteoconduction. Several techniques of bone bioprinting have been developed: inkjet, extrusion, and light-based 3D printers are nowadays available. Bioinks, i.e., the printing materials, also presented an evolution over the years. It seems that these new technologies might be extremely promising for bone regeneration. The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone bioprinting such as selecting cell sources and attaining a viable vascularization within the newly printed bone. The main bioprinters currently available on the market and their characteristics have been taken into consideration, as well.

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The immune reaction and degradation fate of scaffold in cartilage/bone tissue engineering

Cited by 126 publications

References 242 publications

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Solvent-Free Approaches for the Processing of Scaffolds in Regenerative Medicine

Recent Advances in Smart Biomaterials for the Detection and Treatment of Autoimmune Diseases

Advances on Bone Substitutes through 3D Bioprinting

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