The immune-enhancing effect of the Cronobacter sakazakii ES2 phage results in the activation of nuclear factor-κB and dendritic cell maturation via the activation of IL-12p40 in the mouse bone marrow

An, Tae Woo; Kim, Sun Joong; Lee, Young Duck; Park, Jong Hyun; Chang, Hyo Ihl

doi:10.1016/j.imlet.2013.10.007

Cited by 21 publications

(15 citation statements)

References 29 publications

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“…The authors stated that their observation may be important because it suggests that in patients infected with Gram-negative bacteria neither of the phage preparations applied in the therapy—purified phage or products of bacterial lysis in lysate form—stimulated monocytes. Ann et al (2014) reported that the ES2 Cronobacter sakazakii phage activated dendritic cell maturation and caused an increase in the expression IL-12-p40 [51]. These findings may indicate that this phage can induce an inflammatory response.…”

Section: Phages and Inflammationmentioning

confidence: 99%

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Jończyk‐Matysiak

Weber‐Dąbrowska

Owczarek

et al. 2017

Viruses

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Phagocytes are the main component of innate immunity. They remove pathogens and particles from organisms using their bactericidal tools in the form of both reactive oxygen species and degrading enzymes—contained in granules—that are potentially toxic proteins. Therefore, it is important to investigate the possible interactions between phages and immune cells and avoid any phage side effects on them. Recent progress in knowledge concerning the influence of phages on phagocytes is also important as such interactions may shape the immune response. In this review we have summarized the current knowledge on phage interactions with phagocytes described so far and their potential implications for phage therapy. The data suggesting that phage do not downregulate important phagocyte functions are especially relevant for the concept of phage therapy.

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Section: Phages and Inflammationmentioning

confidence: 99%

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Jończyk‐Matysiak

Weber‐Dąbrowska

Owczarek

et al. 2017

Viruses

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“…37 Bacteriophages have furthermore been successfully used as immuno-stimulants to increase expression of pro-inflammatory host factors. 38 Environmental reservoirs C. sakazakii is a ubiquitous bacterium found in a wide variety of reservoirs in the environment; from flies 39 to plants such as wheat, rice, herbs and spices 40 or meat and other common household foods. 41 The wide variety of environments in which C. sakazakii is present, indicates that it has developed various traits that increase survival in difficult conditions, e.g., resistance to UV irradiation, 42 the ability to adhere to various surfaces due to fimbriae formation, 42 biofilm formation 43 and the ability to survive desiccation.…”

Section: Antibiotic Resistance and Alternative Means Of Controlmentioning

confidence: 99%

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

et al. 2014

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“…Given the central role of DCs in the regulation of immune responses, research on the interactions between phages and DCs is essential for understanding the effects of bacterial viruses on the immune system. Over recent years the first studies have been conducted to investigate the influence of bacteriophages on some functions of DCs ( Pajtasz-Piasecka et al, 2008 ; Sartorius et al, 2011 ; Miernikiewicz et al, 2013 ; An et al, 2014 ). All these studies were performed on murine bone marrow-derived dendritic cells (BMDCs); to the best of our knowledge, there are no data on the interactions between phages and human DCs.…”

Section: Introductionmentioning

confidence: 99%

The Effects of T4 and A3/R Bacteriophages on Differentiation of Human Myeloid Dendritic Cells

et al. 2016

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Bacteriophages (phages) are viruses of bacteria. Here we evaluated the effects of T4 and A3/R bacteriophages, as well as phage-generated bacterial lysates, on differentiation of human myeloid dendritic cells (DCs) from monocytes. Neither of the phages significantly reduced the expression of markers associated with differentiation of DCs and their role in the activation of T cells (CD40, CD80, CD83, CD86, CD1c, CD11c, MHC II, PD-L1, PD-L2, TLR2, TLR4, and CCR7) and phagocytosis receptors (CD64 and DEC-205). By contrast, bacterial lysate of T4 phage significantly decreased the percentages of DEC-205- and CD1c-positive cells. The percentage of DEC-205-positive cells was also significantly reduced in DCs differentiated in the presence of lysate of A3/R phage. Thus while bacteriophages do not substantially affect differentiation of DCs, some products of phage-induced lysis of bacterial cells may influence the differentiation and potentially also some functions of DCs. Our results have important implications for phage therapy of bacterial infections because during infections monocytes recruited to the site of inflammation are an important source of inflammatory DCs.

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The immune-enhancing effect of the Cronobacter sakazakii ES2 phage results in the activation of nuclear factor-κB and dendritic cell maturation via the activation of IL-12p40 in the mouse bone marrow

Cited by 21 publications

References 29 publications

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Phage-Phagocyte Interactions and Their Implications for Phage Application as Therapeutics

Cronobacter sakazakii: stress survival and virulence potential in an opportunistic foodborne pathogen

The Effects of T4 and A3/R Bacteriophages on Differentiation of Human Myeloid Dendritic Cells

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