The imbalance of Th17 and regulatory T cells in pemphigus patients

Impaired function of CD19+CD24hiCD38hiregulatory B cells in patients with pemphigus

“…found that peripheral regulatory B10 cells frequencies were significantly higher in patients with autoimmune disease such as rheumatoid arthritis and SLE when compared with healthy controls . Previous studies have also shown a potential imbalance of Tregs in pemphigus . A significant reduction in the number of Tregs may be involved in the breaking of self‐tolerance against Dsg in pemphigus.…”

“…Recently, we observed that CD4 + T cells from Dsg3‐immunized mice provided a direct stimulation to unprimed B cells, suggesting that Dsg3‐reactive T cells are responsible for pathogenic IgG production in patients with pemphigus . In addition to the effector T–B cell interaction, the potential imbalance of CD4 + regulatory T cells (Tregs) has also been implicated in pemphigus . Our previous study demonstrated that CD4 + CD25 hi Foxp3 + Tregs were significantly lower in patients with pemphigus .…”

“…In addition to the effector T–B cell interaction, the potential imbalance of CD4 + regulatory T cells (Tregs) has also been implicated in pemphigus . Our previous study demonstrated that CD4 + CD25 hi Foxp3 + Tregs were significantly lower in patients with pemphigus . The marked reduction of Tregs may be involved in the loss of tolerance against Dsg in pemphigus.…”

Interleukin 4 inhibition as a potential therapeutic in pemphigus

“…Some studies suggested a correlation between severity of disease and Th2 dominancy. There are some growing evidences that suggested the role of Th17 and regulatory T cells in pemphigus [16,89].…”

Antidesmocollin 1 autoantibody negative subcorneal pustular dermatosis-type IgA pemphigus associated with multiple myeloma

“…Additionally, recent reports suggest that autoimmunity associated with lymphoproliferative disorders may be due to specific dysregulation and hyperactivity of B cells, and impaired T‐cell function (imbalance of T‐helper 17 and regulatory T cells). Interestingly, these findings have been described in MM and in pemphigus . Therefore, it is tempting to speculate that the IgA monoclonal protein produced by MM cells may be associated with an autoimmune bullous disease and triggering cutaneous lesions in this subtype of IgA pemphigus.…”