Interleukin 4 inhibition as a potential therapeutic in pemphigus

Tavakolpour, Soheil; Tavakolpour, Vahid

doi:10.1016/j.cyto.2015.09.017

Cited by 49 publications

(36 citation statements)

References 94 publications

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“…Cytokines are cell signaling molecules that are expressed in peptide, protein and glycoprotein forms (21). ILs and IFNs are two specialist types of cytokine required in the management of immune system responses to disease and viral invasion (22). In the present study, serum cytokine production was investigated using ELISA.…”

Section: Discussionmentioning

confidence: 99%

Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

et al. 2017

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Abstract. Coriolus versicolor (CV) contains high levels of bioactive compounds, including the glucan (1→6)-α-D-glucopyranosyl. However, there is a lack of data regarding the potential effect of this CV glucan (CVG) on the stimulation of cytokine production. The present study evaluated the effect of CVG on the stimulation of cytokine production in sarcoma-180-bearing mice. Mice were treated with three doses of CVG (40, 100 or 200 mg/kg body weight) for nine days, after which serum levels of cytokines, namely interleukin (IL)-2, -4, -6, -10, -17A and interferon (IFN)-α and -γ, were investigated by ELISA. CVG significantly promoted the secretion of IL-2, -4, -6, -10, -17A and IFN-α and -γ at the doses of 100 (P<0.05) and 200 (P<0.01) mg/kg, but not at 40 mg/kg (P>0.05), when compared with cyclophosphamide treatment, as a positive control. Additionally, cytokine production associated with T helper (Th)2 and Th17 cells was enhanced compared with that of Th1 cytokines, and the immunomodulatory function of CVG appeared to be IL-10-dependent. These results demonstrate that CVG may stimulate the production of cytokines and serve as a Th2/IL-10-dependent immunomodulator, and thus has promise in supporting cancer therapies.

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Section: Discussionmentioning

confidence: 99%

Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

et al. 2017

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“…For example, targeting a certain cytokine, molecule, or cell could be categorized in the first group. Recently, Tavakolpour[47] suggested that targeting the interleukin (IL)-4 could be a possible treatment in pemphigus. Thereby, dupilumab, an anti-IL-4 receptor alpha monoclonal antibody, was introduced as an effective drug to treat those with pemphigus.…”

Section: Discussionmentioning

confidence: 99%

The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature

Tavakolpour

2016

J Res Med Sci

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Background:Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond.Materials and Methods:PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as “cicatricial pemphigoid” or “ocular pemphigoid” or “mucous membrane pemphigoid” or “MMP” and “intravenous immunoglobulin” or “IVIg” to find all the relevant studies. The last search update was for September 2, 2015. Among the searched items, only English studies were included in the review.Results:After excluding nonrelevant studies, 13 studies with a total number of seventy patients with MMP who were under treatment with IVIg were analyzed. The 65 patients responded completely, one did not respond, two had partially responded, and the remaining two patients stopped IVIg therapy, which resulted in ocular cicatricial pemphigoid progression. Majority of the studies reported mild adverse effects while two of them did not report any unwanted side effect. The most common side effect was headache, followed by nausea. Most of the patients who had a cessation of IVIg therapy before achieving clinical remission experienced the disease progression.Conclusion:Overall, it can be concluded that IVIg therapy was very helpful in treatment of MMP patients who did not respond to conventional therapy or stopped using them for various side effects. Adverse effects associated with IVIg therapy were considerably lower than conventional therapy that can lead toward treatment with this agent in patients who suffer from severe side effects.

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“…Dupilumab has also demonstrated efficacy in adult patients with asthma who were refractory to the standard of care and who had modest eosinophilia [91]. In addition, dupilumab is now being studied for other indications, including chronic sinusitis with nasal polyposis and eosinophilic esophagitis, with publications suggesting that several other diseases may be considered in the future (e.g., pemphigus vulgaris, food allergy) [92,93]. Anti-sense oligonucleotides directed against the common beta chain of the IL-3/IL-5/GM-CSF receptors and the chemokine receptor CCR3…”

Section: Dupilumabmentioning

confidence: 97%

Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update

Wang

Beck

2016

Am J Clin Dermatol

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Atopic dermatitis is one of the most common chronic inflammatory skin diseases. It usually begins in childhood, has a considerable impact on patients' quality of life, and incurs substantial healthcare costs. The standard-of-care treatments for patients with moderate to severe disease are very limited and have variable and typically insufficient efficacy and many side effects, some of which are quite serious. However, over the last decade, considerable advances in our understanding of the pathogenesis of atopic dermatitis have paved the way for a number of new treatments. Most notable are the drugs that target the Th2-polarized immune system, which is thought to play a key role in many of the signs and symptoms characteristic of this disease. In this article, we briefly review the pathophysiology of atopic dermatitis, while noting that each patient's disease phenotype is likely due to a unique interplay of several disease-specific dysregulated pathways. Lastly, we cover emerging therapies for atopic dermatitis, focusing on those that target specific components of the immune system, which are altered in atopic dermatitis. The hope is that these new biologics or small-molecule antagonists, which have high specificity for their target molecules, will decrease the undesirable side effects caused by off-target effects commonly observed with current immunosuppressive agents that are characterized by broad biological actions.

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Interleukin 4 inhibition as a potential therapeutic in pemphigus

Cited by 49 publications

References 94 publications

Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

Effect of Coriolus versicolor glucan on the stimulation of cytokine production in sarcoma-180-bearing mice

The role of intravenous immunoglobulin in treatment of mucous membrane pemphigoid: A review of literature

Immunologic Targets in Atopic Dermatitis and Emerging Therapies: An Update

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