The IL6 gene polymorphism −634C&gt;G and IL17F gene polymorphism 7488T&gt;C influence bone mineral density in young and elderly Japanese women

Oishi, Yoshie; Watanabe, Yoko; Shinoda, Satoshi; Naka, Mamiko; Y, Ozawa; Matsuyama, Tomohiro; Morozumi, Kunio; Fuke, Yoko

doi:10.1016/j.gene.2012.04.054

Cited by 24 publications

(18 citation statements)

References 47 publications

(57 reference statements)

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“…Until now, no other work was reported in the literature relating IL17F polymorphism and GVHD. We did not find association between IL17F genotypes and cGVHD; however other authors showed association between IL17F polymorphism (T/C 7488) and Behçet disease [21], gastric cancer [14], and bone mineral density [22].…”

Section: Discussioncontrasting

confidence: 99%

Il-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-Versus-Host Disease

Cruz

Resende

Correia-Silva

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Section: Discussioncontrasting

confidence: 99%

Il-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-Versus-Host Disease

Cruz

Resende

Correia-Silva

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…For the CC versus CG genotypes, the differences in BMD were not significant. The G allele increased the risk of osteoporosis and many other studies have shown similar data (Ota et al, 2001;Yamada et al, 2003;Li et al, 2008;Oishi et al, 2012;Wang et al, 2013). The differences in BMD among different genotypes for the distal radius had no statistical significance.…”

Section: Discussionmentioning

confidence: 67%

“…A total of four articles (Ota et al, 2001;Yamada et al, 2003;Li et al, 2008;Oishi et al, 2012) with 3068 subjects were included in this study (Figure 1) and the characteristics are summarized in Table 2. All the subjects were Asian and 1942 were women and 1126 were men.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…IL-6 is a multifunctional cytokine regulating immune reactions (Kosa et al, 2009), bone resorption (Nakamura et al, 2014), and osteoarthritis (Valdes et al, 2010). The -174G/C and -634C/G (rs1800796) single nucleotide polymorphisms (SNPs) in the IL-6 gene were found to be associated with IL-6 promoter activity and were significantly associated with BMD (Oishi et al, 2012). Since OP is commonly characterized by lower BMD (Senn et al, 2014), the purpose of this study was to evaluate the correlation between the IL-6 -634C/G polymorphism and risk of OP by meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

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Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis

Yan¹,

R²,

Tu³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched for eligible studies published up to and including December 2014 in English or Chinese. Meta-analysis was conducted by the RevMan5.2 software. Weighted mean difference and 95% confidence interval (95%CI) were calculated by a fixed-effect or random-effect model. Bone mineral density (BMD) was regarded as the assessment index. As a result, a total of four articles with 3068 subjects were included. Differences in BMD between the CC and GG genotypes were 0.03 g/cm 2 (95%CI = 0.01 to 0.05) at total body, 0.01 g/cm 2 (95%CI = 0.00 to 0.03) at femoral neck, and 0.03 g/cm 2 (95%CI = 0.00 to 0.06) at the lumbar spine (P < 0.05). For the CG versus GG genotypes, the differences in BMD were 0.03 g/cm 2 (95%CI = 0.02 to 0.05) at total body and 0.02 g/cm 2 (95%CI = 0.00 to 0.03 at the femoral neck (P < 0.05). For the CC versus CG genotypes, the differences in BMD were not significant (P > 0.05). In conclusion, the GG genotype of L. Yan et al. 19226©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 19225-19232 (2015) the -634C/G polymorphism in IL-6 appears to play a role in reducing BMD, which affects normal bone metabolism and leads to osteoporosis.

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“…The c.677C>T variant enhances enzyme thermolability and is associated with decreased activity of the MTHFR enzyme (Kang et al 1988;Bagley and Selhub 1998), the activity being 65 % in heterozygotes (CT) and 30 % in homozygotes (TT), relative to the CC genotype (Frosst et al 1995). To date, a number of molecular epidemiological studies have been performed to evaluate the association between the MTHFR c.677C>T polymorphism and BMD in diverse populations (Tongboonchoo et al 2013;Shin et al 2013;Pandey et al 2013;Brambila-Tapia et al 2012;Abrahamsen et al 2003;Li et al 2004;Villadsen et al 2005;Hong et al 2007;Yazdanpanah et al 2008;Zhu et al 2009;Agueda et al 2010;Oishi et al 2012;Macdonald et al 2004;McLean et al 2004;Miyao et al 2000;Golbahar et al 2004;Abrahamsen et al 2006;Nissen et al 2009). However, the results are inconsistent or even contradictory.…”

Section: Introductionmentioning

confidence: 99%

Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis

Wang

Liu

et al. 2015

Mol Genet Genomics

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Many studies have reported an association between the methylenetetrahydrofolate reductase (MTHFR) c.677C>T polymorphism and reduced bone mineral density (BMD), but results have been inconsistent. We, therefore, performed a meta-analysis to further explore this association. Twenty-one studies, comprising 33,045 subjects, analyzed the association of MTHFR c.677C>T with femoral neck BMD. Significant association with reduced BMD was observed in Caucasians (recessive model: WMD = -0.004 g/cm(2), 95 % CI -0.008 to -0.006), post-menopausal women (recessive model: WMD = -0.005 g/cm(2), 95 % CI -0.007 to -0.003), men (dominant model: WMD = -0.004 g/cm(2), 95 % CI -0.005 to -0.004; recessive model: WMD = -0.004 g/cm(2), 95 % CI -0.005 to -0.004; TT vs. CC: WMD = -0.006 g/cm(2), 95 % CI -0.006 to -0.006; CT vs. CC: WMD = -0.003 g/cm(2), 95 % CI -0.003 to -0.003), and cohort studies (recessive model: WMD = -0.003 g/cm(2), 95 % CI -0.006 to -0.001). Twenty-two studies, which included 32,271 subjects, analyzed the MTHFR c.677C>T association with lumbar spine BMD. Significant association with reduced BMD was observed in Caucasians, women, post-menopausal women, men, and cohort studies. Seven studies, comprising 6806 subjects, analyzed the MTHFR c.677C>T association with total hip BMD, but no significant association was observed in any population. Nine studies involving 5591 subjects analyzed the association with total body BMD. Significant association with reduced BMD was observed in overall and women subgroup analyses. In summary, this meta-analysis indicates that the MTHFR c.677C>T polymorphism is associated with reduced BMD in lumbar spine and femoral neck in Caucasians, post-menopausal women, and men, and with total body BMD in women. In addition, our results suggest that new studies examining the association between MTHFR c.677C>T polymorphism and BMD of lumbar spine and femoral neck in Asians is warranted, because I (2) > 75.0 % was observed.

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The IL6 gene polymorphism −634C>G and IL17F gene polymorphism 7488T>C influence bone mineral density in young and elderly Japanese women

Cited by 24 publications

References 47 publications

Il-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-Versus-Host Disease

Il-17 Genetic and Immunophenotypic Evaluation in Chronic Graft-Versus-Host Disease

Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis

Association between the methylenetetrahydrofolate reductase c.677C>T polymorphism and bone mineral density: an updated meta-analysis

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