Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis

Yan, Lei; R, Hu; Tu, Shu‐Jiang; Cheng, Wei; Zheng, Qian; Jw, Wang; Ws, Kan; Ren, Yi

doi:10.4238/2015.december.29.32

Cited by 22 publications

(16 citation statements)

References 21 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 10 In addition, many studies have focused on the association between IL-6 and BMD, and advocated IL-6 play an important role in affecting normal bone metabolism and leading to osteoporosis. 11 In Sun’s study, the level of IL-6 was found to be negatively correlated to BMD, and indicating chronic inflammation may increase the serum RANKLE, leading to the occurrence of osteoporosis. 5 In the current study, we found there was significant difference in the level of IL-6 among the three groups, and in the enrolled patients there were positive correlation between 14-3-3η and IL-6.…”

Section: Discussionmentioning

confidence: 94%

The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis

2020

View full text Add to dashboard Cite

Objective: To evaluate the correlation among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis. Methods: In this cross-sectional study, the RA patients treated in our hospital were analyzed between January 2015 and November 2019. Bone mineral density was measured using dual energy X-ray absorptiometry, and at the beginning of the study, serum samples were collected and the level of 14-3-3η, TNF-α, and IL-6 was tested using the quantitative enzyme-linked immunosorbent assay, and I-CTX and PINP were measured using automatic electrochemical luminescence immune-analyzer for all the participants. Results: In the current study, 285 patients with rheumatoid arthritis were enrolled and assigned into normal, osteopenia, and osteoporotic group respectively. The level of 14-3-3η and IL-6 presented with the highest value in the osteoporosis group, but the lowest value in the normal group, and there were significant differences in the level of 14-3-3η and IL-6 among the groups (p<0.05), and there was positive correlation between 14-3-3η and IL-6 (p<0.05). There were significant differences in PINP and I-CTX among the three groups (p<0.05), and a significantly positive correlation between I-CTX and 14-3-3η (p<0.05) and a significantly negative correlation between PINP and 14-3-3η (p<0.05) were found. Conclusion: There was a significant correlation among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis, the influence of 14-3-3η on osteoporosis may be contributed to its adjusting inflammation and bone remodeling. doi: https://doi.org/-10.12669/pjms.36.5.2403 How to cite this:Sun Y, Hong L, Gao C. The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis. Pak J Med Sci. 2020;36(5):---------. doi: https://doi.org/10.12669/pjms.36.5.2403 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Discussionmentioning

confidence: 94%

The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis

2020

View full text Add to dashboard Cite

show abstract

“…An in vitro study has shown that SNPs (rs1800795 and rs1800796) in the promoter region of the IL-6 gene are functionally very important in the susceptibility to CAD 7–9. However, recent genetic population studies are inconclusive regarding associations between the SNPs and circulating IL-6 levels 5,8–10. The reason for the discrepancies among different studies is unclear.…”

Section: Introductionmentioning

confidence: 99%

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Mitrokhin

Nikitin

Brovkina

et al. 2017

JIR

View full text Add to dashboard Cite

This study determined the genotype effects of interleukin (IL)-6/IL-6R single nucleotide polymorphisms (SNPs) on circulating levels of different cytokines in healthy and coronary artery disease (CAD) patients with different allele frequencies. In the control patients, rs1800795 showed significant differences in IL-18 concentrations between CC and CG and CC and GG genotypes (P=0.003 and 0.004, respectively). Furthermore, circulatory IL-1β was significantly different between GC and GG genotypes from the same SNP (P=0.038). In the diseased patients, significance was determined only for IL-2 (P=0.021) between the C and G homozygote allele carriers of rs1800795. The diseased GC and GG genotype carriers were statistically different for IL-2 (P=0.049) from the rs1800796 and for IL-4 (P=0.049) from the rs2228044. IL-4 was also statistically significant between the GC and CC genotypes from the rs2228043 of the IL-6R gene (P=0.025). The last combination of genotypes in the same gene for the same SNP was statistically significant for IL-10 (P=0.036). According to the logistic regression, only gender (odds ratio [OR] =2.43) and triglycerides (OR =1.98) could be taken as determinants of CAD, while examined SNPs genotypes were not identified as risk factors for CAD. In general, the IL-6 polymorphism genotypes were mainly associated with inflammatory cytokines, while the IL-6R polymorphism genotypes were associated with anti-inflammatory cytokines.

show abstract

“…In a clinical study, Yan L et al reported that the GG genotype of the -634C/G polymorphism in IL-6 appears to play a role in reducing BMD, which affects normal bone metabolism and leads to osteoporosis [17].…”

Section: Discussionmentioning

confidence: 99%

Association of pro-inflammatory cytokines with QCT-measured bone mineral density and its gender difference in a Chinese population — a pilot study

Zeng

Gong

et al. 2019

Endokrynologia Polska

View full text Add to dashboard Cite

Introduction: The primary objective of this study was to explore the association of pro-inflammatory cytokines with quantitative computed tomography (QCT)-measured bone mineral density (BMD) and its sexual difference in a Chinese population. Material and methods: In a cross-sectional study, a total of 85 participants aged 48-85 years were recruited and classified into three groups: normal bone mass with BMD > 120 mg/cm 3 , osteopaenia with BMD 80-120 mg/cm 3 , and osteoporosis with BMD < 80 mg/cm 3. ANOVA analysis and multivariable ordinal logistic regression was used to estimate the associations of interest. Results: The proportions of osteoporosis, osteopaenia, and normal BMD were 29.41% (25), 37.65% (32), and 32.94% (28), respectively. Males had the highest proportion of osteopaenia while females had osteoporosis (p < 0.01). In contrast with the null findings in males, significant statistical difference was observed in females. Compared to the normal BMD, the OR for increasing IL-6 level of decreasing BMD groups (osteoporosis and/or osteopaenia) was 9.50 (95% CI: 1.44-62.80). TNF-a and IL-17 tended to show an increased risk (OR > 1) but did not reach significance. Current OR result cannot confirm these relationships of IL-1b, and ORs of PAI-1 and MCP-1 are too close to 1 to determine the practical meaning. Conclusions: IL-6 is an obviously independent risk factor of QCT-measured osteoporosis in Chinese females. Sex hormones and fat-related factors are important confounders in the research of osteoimmunology.

show abstract

Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis

Cited by 22 publications

References 21 publications

The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis

The association among 14-3-3η protein, inflammation, bone remodeling and osteoporosis in patients with rheumatoid arthritis

Association between interleukin-6/6R gene polymorphisms and coronary artery disease in Russian population: inﬂuence of interleukin-6/6R gene polymorphisms on inﬂammatory markers

Association of pro-inflammatory cytokines with QCT-measured bone mineral density and its gender difference in a Chinese population — a pilot study

Contact Info

Product

Resources

About