The Idiotypic Network: Order from the Beginning or Order out of Chaos?

Urbain, Jacques; Brait, Maryse; Bruyns, Catherine; Demeur, Cécile; Dubois, Philippe; Francotte, Myriam; Franssen, Jean-Denis; Hiernaux, Jean; Léo, Oberdan; Marvel, Jacqueline; Meyers, Patricia; Moser, Muriel; Slaoui, Moncef; Tassignon, Jean-Pierre; Urbain-Vansanten, G; Van-Acker, A.; Wikler, Maurice Mosze; Willems, F.; Wuilmart, Christian

doi:10.1007/978-3-642-70675-2_9

Cited by 6 publications

(1 citation statement)

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“…One of these could be that the incidence of B cells, producing Ab2/3-antibodies after immunization with a virus-specific Abl is very low, since Ab2/3-antibodies which mimick a viral epitope may also act as autoThis article is an update of a paper presented at the Symposium on Idiotype Networks and Immune Regulation II, cosponsored by The Southwest Foundation for Biomédical Research, The American Cancer Society ( (3,4). Regulatory forces within the immune system prevent the activation of auto-reactive B or T lymphocytes, and may therefore prevent an Ab2/3 response.…”

Section: Introductionmentioning

confidence: 98%

Induction of Anti-Viral Immune Response by Immunization with Monoclonal Anti-idiotype Antibodies Directed to Private Idiotopes

Osterhaus

Rimmelzwaan²,

Weijer³

et al. 1989

Viral Immunology

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Syngeneic monoclonal anti-idiotypic antibodies were raised against idiotopes on neutralizing monoclonal antibodies with specificity for feline leukemia virus and canine parvovirus. The anti-idiotypic antibodies were shown to recognize paratope-related private idiotopes. Mice were injected with the monoclonal anti-idiotypic antibodies and the sera of these mice were screened for antiviral reactivities. Antibodies to both feline leukemia and canine parvovirus could be induced as determined by ELISA. These results suggest that anti-idiotypic antibodies which detect private idiotopes and thus do not represent internal images of viral antigens may be considered as candidates for the induction of antiviral immunity.

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Section: Introductionmentioning

confidence: 98%