The IDET Procedure for Chronic Discogenic Low Back Pain

Abstract

At 1-year post-IDET, half of patients were dissatisfied with their outcome. The percentage of patients on disability remained constant. The estimated proportion of patients undergoing fusion was predicted to be 15% at 1 year and 30% at 2 years.

Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression

“…Rat-tail IVD would appear to be a good model system for both in vitro and in vivo studies [31,32]. We believe that the data in this study support further investigation of the potential of NGF-targeted therapy in the management of IVD disease [6,33].…”

“…During IVD degeneration, however, nerve fiber ingrowth into the nucleus pulposus (NP) is seen and is believed to possibly contribute to chronic LBP [5]. Consequent therapies targeting neuronal transmission pathways are increasingly being thought to be useful for alleviating pain [6,7]. It is becoming clear, however, that neurotrophins such as NGF and brain-derived neurotrophic factor (BDNF) have a wide range of activities other than neurotransmission that include roles in tissue development, repair, modulation of inflammatory responses and bone and cartilage metabolism [8][9][10][11].…”

Development of a German version of the Oswestry Disability Index. Part 2: sensitivity to change after spinal surgery

“…However, although it has been used as a main outcome measure in other retrospective studies (e.g. [9]), our experience with this question has indicated that it is a confusing construct for some patients to understand. Some report no change in (or even a worsening of) symptoms or disability, but still tend to say ''yes'', as if perhaps interpreting the question to be an enquiry regarding their propensity to think that ''everything's worth a try'' as opposed to a direct evaluation of their perceived outcome after the intervention received.…”

Chapter 4 European guidelines for the management of chronic nonspecific low back pain

“…Unknown (no studies were found on this issue) Safety Some complications have been reported: burning sensations in the legs, which resolved after several weeks; herniation of a disc treated with the procedure and development of radicular pain, numbness and paresis, which resolved after several weeks (Cohen et al 2003); and discitis (Davis et al 2004).…”