The Identification of Genetic Variation in Insulin-Like Growth Factors-I (IGF-I) Gene Region in Some Turkish Sheep Breeds

Tawfeeq, Mustafa; Keskin, İsmail; İlhan, Fatma

doi:10.15316/sjafs.2020.215

Cited by 2 publications

(1 citation statement)

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“…Many candidate genes affect the growth and development of sheep breeds, including IGF-I and IGFALS. IGF-I, also called somatomedin C, is a signaling system consisting of two receptors IGF-1 and IGF-II, and six binding proteins (IGFPB-1-IGFPB-6) [11][12][13]. It has an essential role in growth and development metabolism in various mammals [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Bayraktar

Shoshin

2021

Braz. arch. biol. technol.

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IGF-I and IGFALS play a vital stimulator role in skeletal growth, cell differentiation, metabolism, and other physiological processes. A total of 65 (male and female) animals were used in the study. Animals were measured for growth traits at birth weight, weaning weight, and weights at 6 months. The average daily gain (ADG) was calculated from birth to weaning (ADG1) and from birth to 6th month (ADG2). PCR-RFLP analysis was used to detect IGF-I polymorphism at the 5' regulatory region and IGFALS at Exon 1. Three genotypes (AA, AB and BB) were observed for IGF-I/BfoI locus with allele and genotype frequency 0.79(A) and 0.21(B); 0.71(AA), 0.15(AB) and 0.14(BB). Also, three genotypes (AA, AB and BB) were found for IGFALS/HinfI site with allele and genotype frequency as 0.22(A) and 0.78(B); 0.11(AA), 0.23(AB) and 0.66(BB). The genes were in agreement with Hardy-Weinberg equilibrium (p>0.05). Association analysis suggested that IGF-I and IGFALS significantly affected the growth traits (P<0.05). In terms of birth weight, The AA genotypes of IGF-I were higher than AB and BB. The AB genotype in terms of IGF-I had higher ADG2 compared with other genotypes. The AA genotype of the IGFALS gene was higher in terms of birth weight than other genotypes. In addition, the BB genotype was higher ADG1 than AA and BB. It is suggested that polymorphism of the IGF-I and IGFALS genes may be a potential molecular marker for growth traits in Hamdani sheep.

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Section: Introductionmentioning

confidence: 99%

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Bayraktar

Shoshin

2021

Braz. arch. biol. technol.

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Placental Characteristics Classification of Various Native Turkish Sheep Breeds

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Şirin

et al. 2021

Animals

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The aim of this study was to classify placental characteristics of Akkaraman, Morkaraman, Karayaka, Awassi, Malya, and Bafra sheep breeds using the hierarchical clustering method. In total, 240 individual data records were used as experimental material. Placental characteristics such as total cotyledon surface area, small and large cotyledon length, small cotyledon depth, etc. were used as explanatory variables to classify the breeds’ characteristics. Hierarchical clustering was used with the nearest neighbour method with Euclidean distance in order to classify the sheep breeds’ variations. As a result, six breeds were separated into three clusters: the first cluster consisted of Bafra, Karayaka, and Awassi breeds; the second consisted of Akkaraman and Malya breeds; and the third cluster included only the Morkaraman breed. Bafra and Karayaka were pointed as the nearest breeds, with a similarity of 98.7% in terms of placental characteristics. The similarity rate of the Akkaraman and Malya breeds was at a level of 97.5%, whereas it was 96.8% for Bafra, Karayaka, and Awassi breeds. The similarity of Akkaraman, Karayaka, Awassi, Malya, and Bafra sheep breeds was estimated as 95.7%. The overall similarity was found to be at a level of 93.2% among sheep breeds. The outcomes of the study might be useful as a selection tool for reproductivity and can be used to select the breed to be reared.

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The Identification of Genetic Variation in Insulin-Like Growth Factors-I (IGF-I) Gene Region in Some Turkish Sheep Breeds

Cited by 2 publications

References 10 publications

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Estimate of the Association of IGF-I and IGFALS Genes with Growth Traits in Hamdani Sheep

Placental Characteristics Classification of Various Native Turkish Sheep Breeds

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