The identification of FERM domain protein in serum infected with Plasmodium berghei

Vathsala, P G; Murthy, P Krishna

doi:10.1016/j.euprot.2016.01.008

Cited by 1 publication

(1 citation statement)

References 22 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It usually occurs in the initiation of metastasis in cancer progression. Loss of E-cadherin and gain of N-cadherin are considered to be fundamental events in EMT 21,22. In the present study, we found that columbamine inhibited N-Cadherin expression, and promoted E-cadherin expression, thus inhibiting EMT in colon cancer cells.…”

Section: Discussionsupporting

confidence: 63%

<p>Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway</p>

Lei¹,

Yao²,

Shen³

et al. 2019

CMAR

View full text Add to dashboard Cite

BackgroundColon cancer is one of the most common malignancies worldwide. Because of the side effects and defects in tolerance of chemotherapy, it is necessary to discover new drugs for colon cancer treatment. Columbamine has been identified as an effective anti-osteosarcoma compound with only minor side effects. In this study, we analyzed the anticancer effect of columbamine on colon cancer.MethodsHuman colon cancer cell lines were treatment with columbamine. MTT assay, colony formation assay, apoptosis detection and tumorigenicity assay were performed to detect the protective effect of columbamine on colon cancer development. Western blot assay and luciferase reporter assay were conducted to investigate the potential mechanism of the columbamine treatment.ResultsColumbamine significantly inhibited the proliferation, migration, invasion process of colon cancer cells, and dramatically promoted the apoptosis rate of colon cancer cells to further suppress the development of colon cancer to tumor. Both the signaling transducing and key factors expression of Wnt/β-catenin signaling pathway were obviously repressed by columbamine treatment in a dose-dependent manner.ConclusionThe present study indicated that columbamine exerts its anti-tumor effect in colon cancer cells through abolishing Wnt/β-catenin signaling pathway. Columbamine may be a new therapy compound for colon cancer.

show abstract

Section: Discussionsupporting

confidence: 63%