&lt;p&gt;Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway&lt;/p&gt;

Lei, Changjiang; Yao, Yao; Shen, Bin; Liu, Junru; Pan, Qingyun; Liu, Ning; Li, Lei; Huang, Jianbin; Zhou, Long; Shao, Liwei

doi:10.2147/cmar.s209861

Cited by 15 publications

(10 citation statements)

References 30 publications

(29 reference statements)

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“…The previous report showed that Columbamine suppressed colon cancer cells via blocking Wnt/β-catenin signaling pathway. 12 Lin et al found that Columbamine inhibited hepatocellular carcinoma cells via abolishing of PI3K/AKT, p38 and, ERK1/2 MAPK signaling pathways. 13 Columbamine prevented the development of metastatic osteosarcoma U2OS cells with low cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

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Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma

Niu

Liu

Wang

et al. 2021

CMAR

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Section: Discussionmentioning

confidence: 99%

“…Columbamine prevented the growth and deterioration of colon cancer by blocking the Wnt/β-catenin signaling pathway. 12 Columbamine also inhibits hepatocellular carcinoma development by preventing AKT and ERK1/2 signaling pathways. 13 Meanwhile, Columbamine has a cytotoxic effect on osteosarcoma cells to inhibit tumor development.…”

Section: Introductionmentioning

confidence: 99%

Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma

Niu

Liu

Wang

et al. 2021

CMAR

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“…Columbamine exerts antiproliferative, anti-metastasis, anti-vasculogenic, and cytotoxic effects in various cancer types, including human CRC, HCC, and metastatic osteosarcoma ( Zhang et al, 2014 ; Lei et al, 2019 ). Columbamine significantly decreases tumor volumes in HCT116 or SMMC7721 xenograft mouse model, as well as induces cell apoptosis and G 2 /M phase arrest via Wnt/β-catenin, MAPK, CDK6, STAT3 signaling pathways in in vitro models ( Lin et al, 2019 ).…”

Section: Antitumor Effects and Corresponding Mechanismsmentioning

confidence: 99%

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

Chen

Liang

et al. 2022

Front. Pharmacol.

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Cancer is a serious disease with an increasing number of reported cases and high mortality worldwide. Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Coptidis Rhizoma (C. Rhizoma; Huanglian, in Chinese) is a classical Chinese medicinal botanical drug for the treatment of gastrointestinal disorders and has been shown to have a wide variety of pharmacological activity, including antifungal, antivirus, anticancer, antidiabetic, hypoglycemic, and cardioprotective effects. Recent studies on C. Rhizoma present significant progress on its anticancer effects and the corresponding mechanisms as well as its clinical applications. Herein, keywords related to C. Rhizoma, cancer, gastrointestinal cancer, and omics were searched in PubMed and the Web of Science databases, and more than three hundred recent publications were reviewed and discussed. C. Rhizoma extract along with its main components, berberine, palmatine, coptisine, magnoflorine, jatrorrhizine, epiberberine, oxyepiberberine, oxyberberine, dihydroberberine, columbamine, limonin, and derivatives, are reviewed. We describe novel and classic anticancer mechanisms from various perspectives of pharmacology, pharmaceutical chemistry, and pharmaceutics. Researchers have transformed the chemical structures and drug delivery systems of these components to obtain better efficacy and bioavailability of C. Rhizoma. Furthermore, C. Rhizoma in combination with other drugs and their clinical application are also summarized. Taken together, C. Rhizoma has broad prospects as a potential adjuvant candidate against cancers, making it reasonable to conduct additional preclinical studies and clinical trials in gastrointestinal cancer in the future.

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“…EMT typically initiates metastasis during cancer progression, during which epithelial cells acquire migration and invasion characteristics, and MMPs' expression increases, with the loss of E-cadherin and gain of N-cadherin and Vimentin [54][55][56]. β-catenin is an EMT marker and a core factor of the Wnt signaling pathway.…”

Section: Discussionmentioning

confidence: 99%

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

Wang,

Sun,

et al. 2024

Foods

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Colorectal carcinoma (CRC) is a major global health concern, with cancer metastasis being the main cause of patient mortality, and current CRC treatments are challenged by drug resistance. Although natural compounds, especially in foods like hawthorn proanthocyanidin extract (HPOE), have good anticancer activity, their effects on CRC metastasis remain unknown. Therefore, our objective was to investigate the impact and potential mechanisms of HPOE on the movement and infiltration of cells in the HCT116 CRC cells. Firstly, scratch-healing experiments confirmed the anti-migratory and anti-invasive capabilities of HPOE. Then, network pharmacology identified 16 possible targets, including MMP-9. Subsequently, RT-qPCR and Western blotting experiments confirmed that HPOE downregulated epithelial-mesenchymal transition-related factors (N-cadherin and MMP-9) and inhibited Wnt/β-catenin pathway activation. Finally, these results were experimentally validated using the Wnt pathway activator Licl and inhibitor XAV939. It was confirmed that HPOE had a certain inhibitory effect on the activation of the Wnt signaling pathway caused by the activator Licl and could enhance the inhibitory effect of the inhibitor XAV939. Our findings provide a basis for developing functional foods or dietary supplements, especially positioning HPOE as a functional food raw material for adjuvant treatment of CRC, given its ability to inhibit metastasis through the Wnt/β-catenin pathway.

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<p>Columbamine suppresses the proliferation and malignization of colon cancer cells via abolishing Wnt/β-catenin signaling pathway</p>

Cited by 15 publications

References 30 publications

Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma

Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma

Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers

Hawthorn Proanthocyanidin Extract Inhibits Colorectal Carcinoma Metastasis by Targeting the Epithelial-Mesenchymal Transition Process and Wnt/β-Catenin Signaling Pathway

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