The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility

Abstract

(2012) The identification of candidate genes and SNP markers for classical bovine spongiform encephalopathy susceptibility, Prion, 6:5,[461][462][463][464][465][466][467][468][469]

Manganese and Prion Disease

“…Interestingly, recent genome-wide studies of Kuru confirmed a strong association with a single nucleotide polymorphism (SNP) localized within codon 129 and also with two other SNPs localized within the gene's retinoic acid receptor beta (RARB) and in stathmin like 2 (STMN2; the gene encoding SCG10, a neuron-specific growth-associated protein). 37,38 Importantly, studies have shown that individuals with PRNP 129 Val/Val and 129 Met/Met genotypes are susceptible to Kuru, 39 whereas heterozygosity at codon 129 confers relative resistance to prion diseases. 40 An evolutionarily strong balancing selection for these alleles had been imposed at this locus, not only in Fore, but also in other human populations practicing cannibalism.…”

Combination of SYBR Green II and TaqMan Probe in the adulteration detection of Dendrobium devonianum by fluorescent quantitative PCR

“…However, the methods mentioned above are heat labile, so they are not suitable for identifying processed healthcare products or medicine at the species level. On the other hand, welldeveloped molecular marker techniques such as single nucleotide polymorphisms (SNPs), microsatellite DNA (SSR) and amplified fragment length polymorphism (RFLP) can only be used to identify fresh materials, but are helpless for finished food products (Scheidegger et al, 2009;Sahu et al, 2012;Thomson et al, 2012). On the other hand, real-time fluorescent quantitative polymerase chain reaction (real-time PCR), one of the recently emerging techniques, has been widely used in identification of food species and in medical fields (Gambino, 2015;Guo et al, 2015).…”

The effects of exposure to the environmental neurotoxicant manganese on α-synuclein and its cell-to-cell transmission via exosomes

“…Additionally, Kuru is considered largely a cerebellar syndrome with ataxia, tremors, and choreiform and athetoid movements being the prominent clinical signs of the disease (Alpers, 1987); dementia is a late and less prominent symptom. Interestingly, recent genome-wide studies of Kuru confirmed a strong association with a single nucleotide polymorphism (SNP) localized within the codon 129 and also with two other SNPs localized within the genes retinoic acid receptor beta (RARB) and stathmin like 2 (STMN2; the gene encoding SCG10) (Lockwood, 1989;Thomson et al, 2012).…”