To my father G.D. Harischandra and mother Priyani Jayamanna, thank you for allowing me to follow my ambitions throughout my childhood iii TABLE OF CONTENTS ABSTRACT v CHAPTER I. GENERAL INTRODUCTION 1 Dissertation Organization 1 Introduction 3 Background and Literature Review I 8 Manganese; its role and significance in Parkinsonism Spectrum Disorders 8 Background and Literature Review II 64
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