The identification of benzodiazepine receptors with brain-like specificity in bovine retina

Serotonin‐Containing Neurones in Vertebrate Retinas

“…A number of reports have also suggested that noradrenaline (NA) (Osborne, 1981a), glycine, and glutamate (see Graham, 1974;Voaden, 1976;Voaden et al, 1980), enkephalin (Brecha et al, 1979), substance P , somatostatin , neurotensin and vasoactive intestinal peptide , cholecystokinin (Osborne et al, 1981a), and bornbesin (Osborne and Dockray, 1982) have specific functions in the retina. Even benzodiazepine receptors exist in the retina (Osborne, 19806;Regan et al, 1980;Borbe et al, 1980), which is puzzling in view of its proposed role in emotional types of behaviour (Robertson, 1979).…”

The Peripheral‐Type Benzodiazepine Receptor Ligands [3H]Ro 5‐4864 and [3H]PK 11195 Bind to the Retina of Rabbit, but Not of Turtle

“…In humans, the administration of BDZs can modify the visual performance (e.g., Smith and Misiak, 1976), and it is possible that this is due, at least in part, to an action at the retinal level, because experimental studies have shown modifications of some electroretinographic parameters induced by these drugs (Schultze and Appel, 1977;Jaffe et al, 1986). However, these effects may result from an action on CBRs, whose presence has been shown in several species, including humans (Howells et al, 1979;Young and Kuhar, 1979;Borbe et al, 1980;Paul et al, 1980;Biggio et al, 1981). In order to get an insight into the possible functional role(s) of PBRs in the rabbit retina, it would be interesting to study the effects of Ro 5-4864 or PK 11 195 on specific aspects of retinal function.…”