The IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification

Abstract

We propose to tailor TNM classification of multiple pulmonary sites of lung cancer to reflect the unique aspects of four different patterns of presentation. We hope that this will lead to more consistent classification and clarity in communication and facilitate further research in the nature and optimal treatment of these entities.

The IASLC Lung Cancer Staging Project: A Renewed Call to Participation

“…22 From this second, international database, the IASLC SPFC developed recommendations toward the eighth edition of the TNM staging system. These recommendations were published in 2015, 2016, and 2017 [23][24][25][26][27][28][29][30][31][32][33] and were once again accepted by the UICC 34 and AJCC 35 in 2017 (with AJCC implementation effective in 2018) and included in the second edition of the IASLC Staging Manual in Thoracic Oncology and the IASLC Staging Handbook in Thoracic Oncology.…”

A case of different EGFR mutations in surgically resected synchronous triple lung cancer

“…In recent years, great advances have been made in distinguishing multifocal lung cancer using gene profile analyses, such as comparative genomic hybridization or next-generation sequencing (8,9); however, there is no gold-standard method, and the available methods are too complex to feasibly integrate into routine clinical practice. We therefore adhered to the clinical and pathological criteria of the IASLC Lung Cancer Staging Project (2). In the present case, each lesion had a different radiographic appearance, different pathological subtype, and different EGFR mutation status.…”

Epidemiology, risk factors, symptomatology, TNM classification of Non Small Cell Lung Cancer. An overview while waiting the 8th TNM classification

“…However, in this area a further classification has also been proposed (N1a, N1b, N2a, N2b, and N3) (63). In addition, Detterbeck FC et al proposed an inclusion of LC types that are presented as multiple pulmonary sites or multiple nodules with ground glass or lepidic features or LC with a pneumonic type of involvement in the 8 th TNM classification (64,65). The health professionals who are engaged with the therapy and diagnosis of NSCLC and generally LC anticipate the upcoming TNM classification as it is expected to change the therapeutic approach of one to six patients (57,58).…”