The Üstikuddus sherbiti in the treatment of abnormal cold and dry-type depression patients with comorbid anxiety: A randomized and controlled clinical trial

Abstract

Objective: To evaluate the clinical effect of Üstikuddus sherbiti (US), a traditional herbal prescription of Uyghur medicine, in the treatment of cold and dry-type major depression disorder (MDD) patients with comorbid anxiety. Methods: A total of 150 cold and dry-type depressive patients with comorbid anxiety were randomly divided into three groups of 50 patients; then they were, respectively, treated with US, modern medicine Fluoxetine, and the combination of Fluoxetine and US. The depression degrees of patients were evaluated zero and six weeks after the treatment based on the Hamilton Anxiety Scale (HAMA), in the clinical study. Analysis of variance (ANOVA) was used to detect significant differences at various time points or among the three groups. Statistical analysis was performed by SPSS version 21.0. Results: The main results are as follows: After taking the medicine, the depressive condition of patients with comorbid anxiety in the three groups was getting better with the passage of time; particularly, the clinical efficacy of US combined with Fluoxetine was significantly improved, indicating that the effect of combined treatment is better than treatment with pure Fluoxetine or pure US treatment. Statistical difference exists between the end time point within groups, but not among the three groups. Moreover, in the detection process of the patient’s physical indicators, no obvious side effects were found. These results together suggested that US can strengthen the curative effect of modern medicine in the treatment of depression, which would lay a foundation for studying the molecular mechanism and potential target of US. Conclusion: Fluoxetine and US combination therapy played a significant role in the treatment of depressive symptoms, suggesting that it can improve the curative effect of depression. The study provided a new way of thinking to clarify the US molecular mechanism for the treatment of depression and potential target.

A study on sleep apnea in patients with abnormal sewda type of depression

“…Abnormal dry and cold humor is the main cause of depression, because it could make related organ and tissue dysfunctions or injuries. 7,8 Abnormal dry and cold body fluid-type depression is the main syndrome type of depression. Patients with abnormal dry cold fluid qualitative depression-related insomnia, in addition to showing depression in work and interest, slowness, inferiority, despair, and other typical depressive emotions, typical symptoms of depression, somatization and sleep disorders are also very prominent.…”

“…Patients with abnormal dry cold fluid qualitative depression-related insomnia, in addition to showing depression in work and interest, slowness, inferiority, despair, and other typical depressive emotions, typical symptoms of depression, somatization and sleep disorders are also very prominent. 7,8 Some patients with abnormal dry cold body fluid-type depression have mental symptoms that are not typical, but instead highlight somatization or sleep disorders. Therefore, some of the chronic insomniacs treated are depression patients, but it is difficult to distinguish only from the clinical symptom characteristics, so the analysis of the characteristics of sleep disorders in abnormal dry cold body fluid-type depression has scientific significance and clinical practice value.…”

“…Before completing this form, purpose of the survey was informed to patients by the doctors, questionnaire was completed independently by patients. 7,8…”

“…9 According to TUM certificate, total 127 MDD patients were classified by abnormal body fluid dialectics. 7,8…”

“…6 As for diagnosis, classification, prevention and treatment of depression, traditional Uyghur medicine (TUM) has its own experiences. 7,8 However, the sleep of depression in TUM has not been reported with PSG research. Therefore, in order to provide a theoretical basis for clinical treatment and prevention of depression, in this study, PSG was used to monitor the whole night sleep and to explore the sleep structure characteristics of the patients with comorbid sleep disorders and abnormal sewda (dry and cold body fluid) type depression.…”