1992
DOI: 10.1080/09553009214550671
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Thein VitroRadiosensitivity of Lymphocytes from Chronic Lymphocytic Leukaemia Using the Differential Staining Cytotoxicity (DiSC) Assay. I—Investigation of the Method

Abstract: A tumour sensitivity assay, the differential staining cytotoxicity (DiSC) assay, which has been shown to have potential in predicting tumour response to cytotoxic drugs, has been developed to investigate the radiosensitivity of peripheral blood lymphocytes isolated from patients with chronic lymphocytic leukaemia (CLL). The method involved irradiating isolated lymphocytes (0.64-20.48 Gy at 8 x 10(5) cells/ml) and incubating for 4 days. Subsequent radiation-induced cell kill was assessed by differential stainin… Show more

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Cited by 4 publications
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