Predictive Assays in Radiation Therapy

West, Catharine

doi:10.1016/b978-0-12-035418-4.50010-7

Advances in Radiation Biology

1994

DOI: 10.1016/b978-0-12-035418-4.50010-7

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Predictive Assays in Radiation Therapy

Catharine West

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Cited by 16 publications

(15 citation statements)

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confidence: 99%

“…These variations in radiosensitivity play an important role in tumour response to radiation therapy; tumours that contain more radioresistant cells do not respond as well to therapy (West, 1994). There are many factors that contribute to variations in sensitivity (West, 1994;Szumiel, 1981). Some of the variations in radiation sensitivity reflect the sensitivity of the tissue from which the tumour developed (Fertil and Malaise, 1985;Weichselbaum et al, 1989).…”

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A role for chromosomal instability in the development of and selection for radioresistant cell variants

et al. 2001

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Summary Chromosome instability is a common occurrence in tumour cells. We examined the hypothesis that the elevated rate of mutation formation in unstable cells can lead to the development of clones of cells that are resistant to the cancer therapy. To test this hypothesis, we compared chromosome instability to radiation sensitivity in 30 independently isolated clones of GM10115 human-hamster hybrid cells. There was a broader distribution of radiosensitivity and a higher mean SF 2 in chromosomally unstable clones. Cytogenetic and DNA double-strand break rejoining assays suggest that sensitivity was a function of DNA repair efficiency. In the unstable population, the more radioresistant clones also had significantly lower plating efficiencies. These observations suggest that chromosome instability in GM10115 cells can lead to the development of cell variants that are more resistant to radiation. In addition, these results suggest that the process of chromosome breakage and recombination that accompanies chromosome instability might provide some selective pressure for more radioresistant variants.

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A role for chromosomal instability in the development of and selection for radioresistant cell variants

et al. 2001

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“…Traditionally, tests of intrinsic tumour radiosensitivity have made use of either colony-forming (West et al, 1991) or population-growth assays (Brock et al, 1989), but there is an abundance of other approaches (West, 1994). Recently, there has been increasing interest in normal tissue radiosensitivity assays that use skin fibroblasts or peripheral blood lymphocytes (PBLs).…”

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Comparison between radiation-induced cell cycle delay in lymphocytes and radiotherapy response in head and neck cancer

Tell¹,

Heiden²,

Granath³

et al. 1998

Br J Cancer

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Summary A study was made evaluating the use of radiation-induced cell cycle delay in lymphocytes to predict tumour response to radiotherapy. Peripheral blood lymphocytes were isolated from whole blood from 49 patients with head and neck cancer before treatment with radiotherapy and from 25 healthy donors. The clinical response to radiotherapy was assessed at 0-2 months after treatment. The level of radiation-induced cell cycle delay was measured using flow cytometry after mitogen stimulation of lymphocytes. The analysis of ten normal donors gave no significant difference in variability between the intra-assay and the intra-donor samples. However, the cell cycle data for lymphocytes from these healthy donors showed significant inter-individual differences in G2 phase accumulation. Patients showing no response to radiotherapy had a high level of S-phase cells compared with partial (P < 0.001) and complete responders (P = 0.016). An inverse relationship was found when analysing the fraction of cells in G2 (P= 0.009 and 0.034 respectively). In general, healthy donors had similar cell cycle kinetics compared with the non-responders. In conclusion, the result indicates that radiation-induced cell cycle delay in lymphocytes is inversely correlated with tumour response to radiotherapy in head and neck cancer patients. However, the value of the present test for predicting individual tumour response is limited, because of assay variability and overlap between groups.

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“…The test was suggested as a predictive assay. 40 Her work showed that in vitro measurement of tumor cell radiosensitivity is a highly significant prognostic factor for carcinoma of the cervix treated with radiotherapy 41 (Fig. 6).…”

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The contribution of women to radiobiology: Marie Curie and beyond

Gasińska

2016

Reports of Practical Oncology & Radiotherapy

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Radiobiology Ionizing radiationTumor radiobiology a b s t r a c t Marie Sklodowska-Curie, an extraordinary woman, a Polish scientist who lived and worked in France, led to the development of nuclear energy and the treatment of cancer. She was the laureate of two Nobel Prizes, the first woman in Europe who obtained the degree of Doctor of Science and opened the way for women to enter fields which had been previously reserved for men only. As a result of her determination and her love of freedom, she has become an icon for many female scientists active in radiation sciences. In 1911, Marie Sklodowska-Curie was awarded her second Nobel Prize for the discovery of radium. Her pioneering work demonstrated that radiation is a powerful tool with a wide range of potential applications, which include a range of diagnostic and therapeutic medical procedures. Marie Curie has left a great deal to the world. Her work led to the development http://dx

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Predictive Assays in Radiation Therapy

Cited by 16 publications

References 130 publications

A role for chromosomal instability in the development of and selection for radioresistant cell variants

A role for chromosomal instability in the development of and selection for radioresistant cell variants

Comparison between radiation-induced cell cycle delay in lymphocytes and radiotherapy response in head and neck cancer

The contribution of women to radiobiology: Marie Curie and beyond

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