The Hypothalamo-Hypophyseal Antidiuretic System in Physical Exercises

Kozłowski, S; Szczepańska, Ewa; Zielinski, Agata

doi:10.3109/13813456709089572

Cited by 16 publications

(10 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, distinct mechanisms seem to be responsible for post-exercise macro-proteinuria and NGAL up-regulation in nephron units. It is of note that 100% of individuals tested in the current study presented with PeP (as initially defined) following maximal exercise, supporting previous findings that when exercise is of sufficient intensity, all individuals will have some degree of PeP [27,28].…”

Section: Discussionsupporting

confidence: 71%

“…For example, the elevation in median uNGAL at 25 minutes may in part be explained by the oliguria at that same time point, a conclusion supported by the significant negative correlation with percentage change in urine volume between pre and 25 minutes. Exercise is known to exert an anti-diuretic effect with numerous studies demonstrating a decrease in free water clearance in both dehydrated and hyperhydrated states [1,28]. It is also plausible that the significant decrease in median uNGAL at two hours is due to relative polyuria -again supported by correlation with percentage change in urine volume.…”

Section: Discussionmentioning

confidence: 63%

“…Such uNGAL elevations could be a result of increased inflammatory injury to nephron units -specifically at the proximal tubule -with subsequent impairment in function [9,[24][25][26]. Specifically, this may affect tubular reabsorption of NGAL as reabsorption of other small molecular weight proteins such as lysozyme and β 2 -microglobulin are known to be inhibited by exercise [1,27,28]. Of note, leucocytouria has been discovered as a source of uNGAL elevations in the absence of AKI (e.g.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Does Proteinuria-Inducing Physical Activity Increase Biomarkers of Acute Kidney Injury?

Junglee

Lemmey

et al. 2012

Kidney Blood Press Res

View full text Add to dashboard Cite

Aim: We sought to determine if an acute kidney injury biomarker, neutrophil gelatinaseassociated lipocalin (NGAL), would be up-regulated by high-intensity proteinuria-inducing exercise. Methods: A prospective cohort design was utilised. 100 healthy, active adults (mean age 24 ± 4 (SD) years) were screened for post-exercise proteinuria (PeP); 10 PeP positive and 10 PeP negative participants then completed a high-intensity exercise protocol involving an 800 meter sprint. Plasma and urinary NGAL, urinary creatinine, urinary albumin and urine volume were obtained at the following time points: pre-run, immediately post-, 25 minutes, one hour and two hours post-run. Results: Following high-intensity exercise, 64% of participants had urinary NGAL concentrations above the normal range, particularly at 25 minutes post (P = 0.002). However, there was no difference in NGAL response between PeP positive and negative groups and plasma NGAL was decreased, not elevated, following exercise (P = 0.002). In some individuals normalizing urinary NGAL for urinary creatinine attenuated elevations. Urinary NGAL was also negatively correlated with urine volume (r = -0.701, P = 0.005). Conclusion: Proteinuria susceptibility did not influence an acute injury biomarker response to exercise. Nevertheless, urinary NGAL was elevated by exercise, possibly due to increased production by the proximal tubule, increased plasma clearance (given the decrease in plasma NGAL) and/or a concentrating effect of exercise-induced oliguria. Until correct normalisation of urinary biomarkers is determined, NGAL should be interpreted cautiously in exercise and acute kidney injury-induced oliguria. The inter-individual NGAL response to exercise also warrants further investigation.

show abstract

Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Does Proteinuria-Inducing Physical Activity Increase Biomarkers of Acute Kidney Injury?

Junglee

Lemmey

et al. 2012

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Plasma ADH levels rise during sustained exercise [18,19]. In a study when volunteers had a water diuresis prior to exercise, the exercise-induced rise in plasma ADH correlated strongly with the fall in water diuresis, and both these changes were inhibited by ethyl alcohol [20], but when exercise was preceded by antidiu resis, this relationship was not apparent [18].…”

Section: Discussionmentioning

confidence: 99%

Effects of Exercise on Renal Function in Patients with Moderate Impairment of Renal Function Compared to Normal Men

Taverner

Craig²,

Mackay³

et al. 1991

Nephron

View full text Add to dashboard Cite

The renal excretory and haemodynamic responses to sustained moderate exertion were investigated in normotensive humans with impaired renal function and normal volunteers. The heart rate increase with exercise was similar in each group. Subjects with impaired renal function showed a significant fall in glomerular filtration rate on exertion, while normals did not. In the presence of renal disease, urine osmolality did not rise with exertion, although it rose markedly in the normal group. Free water clearance became negative after exercise in the normal group only. The diseased kidney is unable to maintain glomerular filtration rate or conserve water under the stress of exertion as well as the normal kidney.

show abstract

“…injection of vasopressin. Kozlowski, Szczepanska & Zielinski (1967) studied the effects of exercise on a bicycle ergometer on bioassayable plasma AVP levels in man and found a significant rise after 20 min exercise at a high work rate which they attributed to both changes in plasma osmolality and in blood volume distribution. In our studies there was a significant increase in plasma osmolality associated with exercise so that it reached the same level as seen after overnight dehydration.…”

Section: Frusemide Dehydration Studiesmentioning

confidence: 98%

Radioimmunoassay of Plasma Vasopressin in Physiological and Pathological States in Man

Beardwell¹,

Geelen²,

Palmer³

et al. 1975

Journal of Endocrinology

View full text Add to dashboard Cite

A radioimmunoassay method for the measurement of arginine-vasopressin (AVP) in human plasma has been developed which requires 5 ml of plasma and has a lower limit of detection of 1-8 pg/ml plasma. Arginine-vasopressin was found to be stable in whole blood for up to 1 h at room temperature and for at least 4 h at 4 degrees C, while in plasma stored at -20 degrees C no loss was seen over 10 days. Dehydration and rehydration in normal subjects produced appropriate changes in AVP concentration but there was considerable variability in the levels attained by individual subjects and no obvious correlation with plasma osmolality. No consistent increase in plasma AVP concentration was seen on change of posture from the recumbent to the upright position. Vigorous exercise produced a marked rise in plasma AVP concentrations in most subjects which could not be attributed simply to an increase in plasma osmolality. In fusion studies with Pitressin in normal subjects showed a mean half-life of 6-4 min with an overall plasma clearance rate of 8-5 ml/min/kg body weight and a mean volume of distribution of 5-33 l. In patients with a biochemical picture suggestive of inappropriate antidiuretic hormone secretion, markedly raised plasma AVP concentrations were found only in patients with bronchial carcinoma.

show abstract

The Hypothalamo-Hypophyseal Antidiuretic System in Physical Exercises

Cited by 16 publications

References 12 publications

Does Proteinuria-Inducing Physical Activity Increase Biomarkers of Acute Kidney Injury?

Does Proteinuria-Inducing Physical Activity Increase Biomarkers of Acute Kidney Injury?

Effects of Exercise on Renal Function in Patients with Moderate Impairment of Renal Function Compared to Normal Men

Radioimmunoassay of Plasma Vasopressin in Physiological and Pathological States in Man

Contact Info

Product

Resources

About