Effects of Exercise on Renal Function in Patients with Moderate Impairment of Renal Function Compared to Normal Men

Taverner, David; Craig, Kate; Mackay, Ian; Watson, Michael

doi:10.1159/000186277

Cited by 20 publications

(15 citation statements)

References 18 publications

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“…Taverner et al [18] found that among subjects performing 30 min of aerobic exercise on a cycle ergometer, post-exercise HR was higher in pre-dialysis CKD patients than in control subjects. The authors limited the intensity of the exercise by not allowing subject's HR to exceed 110 bpm.…”

Section: Discussionmentioning

confidence: 99%

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Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD

et al. 2016

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Background: This study aimed at evaluating the after effects of a single bout of aerobic exercise on muscle sympathetic nerve activity (MSNA), peripheral vascular resistance and blood pressure (BP) in stages 2-3 chronic kidney disease (CKD) patients. We hypothesized that CKD patients present a greater decline in these variables after the exercise than healthy individuals. Methods: Nine patients with stages 2-3 CKD (50 ± 8 years) and 12 healthy volunteers (50 ± 5 years) underwent 2 sessions, conducted in a random order: exercise (45 min, cycle ergometer, 50% of peak oxygen uptake) and rest (seated, 45 min). Sixty minutes after either intervention, MSNA (by microneurography), BP (by oscillometry), and forearm vascular resistance (FVR) were measured. A 2-way analysis of variance with group (between) and session (within) as main factors was employed, accepting p < 0.05 as significant. Results: Diastolic BP and MSNA were higher in the CKD than the control group in both sessions. Responses after exercise were similar in both groups. Systolic BP, diastolic BP, MSNA and FVR were significantly lower after the exercise than after the rest session in both the CKD and the control groups (162 ± 15 vs. 152 ± 23 and 155 ± 11 vs. 145 ± 16 mm Hg, 91 ± 11 vs. 85 ± 14 and 77 ± 5 vs. 71 ± 10 mm Hg, 38 ± 4 vs. 31 ± 4 and 34 ± 2 vs. 27 ± 4 burst/min, 59 ± 29 vs. 41 ± 29 and 45 ± 20 vs. 31 ± 8 U, respectively, all p < 0.05). Conclusion: These results showed that aerobic exercise may produce hemodynamic and neural responses that can be beneficial to these patients in spite of CKD.

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Section: Discussionmentioning

confidence: 99%

“…Regular physical exercise can improve cardiovascular function [16][17][18] , being beneficial for the treatment of various chronic diseases [18] , including hypertension and the primary and secondary prevention of coronary atherosclerosis [16] .…”

Section: Introductionmentioning

confidence: 99%

Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD

et al. 2016

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“…For instance, exercise has been reported to result in a transient fall in glomerular filtration rate and fluid retention in humans with CKD (111). However, these exerciseinduced alterations do not appear to exacerbate preexisting renal dysfunction.…”

Section: Effect On Renal Functionmentioning

confidence: 99%

Skeletal muscle dysfunction in chronic renal failure: effects of exercise

Adams¹,

Vaziri²

2006

American Journal of Physiology-Renal Physiology

113

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A number of chronic illnesses such as renal failure (CRF), obstructive pulmonary disease, and congestive heart failure result in a significant decrease in exercise tolerance. There is an increasing awareness that prescribed exercise, designed to restore some level of physical performance and quality of life, can be beneficial in these conditions. In CRF patients, muscle function can be affected by a number of direct and indirect mechanisms caused by renal disease as well as various treatment modalities. The aims of this review are twofold: first, to briefly discuss the mechanisms by which CRF negatively impacts skeletal muscle and, therefore, exercise capacity, and, second, to discuss the available data on the effects of programmed exercise on muscle function, exercise capacity, and various other parameters in CRF.

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“…On the morning of study the patient had no breakfast and refrained from caffeine and alcohol. Via an antecubital vein, inulin and para-aminohippurate (PAH) were infused for the measurement of renal clearances according to a standard protocol (Taverner et al, 1991). Subjects were given an oral water load of 200 ml at the start of the study and 100 ml every 0.5 h thereafter.…”

Section: Methodsmentioning

confidence: 99%

The effects of selective beta‐adrenoceptor antagonists and partial agonist activity on renal function during exercise in normal subjects and those with moderate renal impairment.

Taverner

Mackay

Craig

et al. 1991

Brit J Clinical Pharma

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1 The effects of sustained moderate exercise in the sitting position on renal haemodynamics and glomerular filtration were measured in six normotensive patients with moderately impaired renal function and seven age-matched normal volunteers. 2 The changes in the effects of exercise on renal function induced by chronic cardioselective ,B-adrenoceptor blockade by drugs with (epanolol) and without intrinsic sympathomimetic activity (atenolol) were examined. 3 Both ,B-adrenoceptor blockers attenuated the heart rate increase with exercise, but only atenolol lowered blood pressure significantly. In resting volunteers on atenolol, associated with the fall in blood pressure there was a significant reduction in glomerular filtration rate. 4 Glomerular filtration fell significantly in all groups with exercise, and renal blood flow also fell in parallel. These changes were not influenced by drug treatment. 5The exercise-induced rise in PRA was suppressed by atenolol but not by epanolol. 6 The renal function and haemodynamic responses to moderate exercise does not appear to be mediated by the systemic renin-angiotensin system or by 13l-adrenoceptors.

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Effects of Exercise on Renal Function in Patients with Moderate Impairment of Renal Function Compared to Normal Men

Cited by 20 publications

References 18 publications

Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD

Post-Exercise Hypotension Is Mediated by a Decrease in Sympathetic Nerve Activity in Stages 2-3 CKD

Skeletal muscle dysfunction in chronic renal failure: effects of exercise

The effects of selective beta‐adrenoceptor antagonists and partial agonist activity on renal function during exercise in normal subjects and those with moderate renal impairment.

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