The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited

Engelmann, Mario; Landgraf, Rainer; Wotjak, Carsten T.

doi:10.1016/j.yfrne.2004.09.001

Cited by 390 publications

(262 citation statements)

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“…Prolonged and repeated exposures to unavoidable, aversive stimuli may lead to a dysregulation of the hypothalamic-pituitary-adrenocortical (HPA) axis, the major endocrine component of the stress response. A maladaptive stress response is thought to be causally linked to a variety of human disorders including mood disorders (Chrousos and Gold, 1992, Chrousos, 1998, Holsboer, 2000, McEwen, 2000, Engelmann et al, 2004. The physiological foundation of the HPA axis is constituted by parvocellular neurons of the hypothalamic paraventricular nucleus (PVN).…”

Section: Introductionmentioning

confidence: 99%

“…(Landgraf and Wigger, 2002, Scott and Dinan, 2002, Keck, 2006, Landgraf, 2006, Frank and Landgraf, 2008, Simon et al, 2008, Surget and Belzung, 2008, Ryckmans, 2010. As both psychiatric disorders are considered to be stress related and AVP has a regulatory role in the HPA axis (Engelmann et al, 2004, Makara et al, 2004, Murgatroyd and Spengler, 2011, this connection is reasonable to propose. In particular, the strong connection between chronic stress and depression (see e.g.…”

mentioning

confidence: 98%

“…septum from the PVN or amygdala from the SON) (Engelmann et al, 2004, Landgraf, 2006. To differentiate between the roles of AVP signaling originating in the PVN versus SON, repeated forced swimming (FS) was chosen as stressful stimulus.…”

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confidence: 99%

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Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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Short title:Stress-related behavior in Brattleboro rat after DDAVP treatment You created this PDF from an application that is not licensed to print to novaPDF printer (http://www.novapdf.com) Balázsfi et al. 2Highlights  The effect of AVP on affective and memory symptoms is due to its central role  DDAVP treatment compensated the peripheral effects of congenital AVP absence  DDAVP did not significantly alter the behavior of KO animals in the paradigms tested  AVP signaling in the medial amygdala contributes to the behavioral effect measured in FS AbstractBeside its hormonal function in salt and water homeostasis, vasopressin -released into distinct brain areas -plays a crucial role in stress-related behavior resulting in the enhancement of an anxious/depressive-like state.We aimed to investigate whether correction of the peripheral symptoms of congenital absence of AVP also corrects the behavioral alterations in AVP-deficient Brattleboro rats. Wild type (WT) and vasopressin-deficient (KO) male Brattleboro rats were tested.Half of the KO animals were treated by desmopressin (V2-receptor agonist) via osmotic minipump (subcutaneous) to eliminate the peripheral symptoms of vasopressin-deficiency. Anxiety was studied by elevated plus maze (EPM), defensive withdrawal (DW) and marble burying (MB) tests, while depressive-like changes were monitored in forced swimming (FS) and anhedonia by sucrose preference test. Cell activity was examined in septum and amygdala by c-Fos immunohistochemistry after 10min FS.

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Section: Introductionmentioning

confidence: 99%

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confidence: 98%

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Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Balázsfi

Pintér

Klausz

et al. 2015

Psychoneuroendocrinology

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“…This response promotes affiliative and social behaviour in response to stressful circumstances (Boutet et al, 2006;Engelmann et al, 2004;Lippert et al, 2003), maximising fitness through care (or 'tending') of offspring or others during periods of stress. However, the relationship in which OT suppresses or attenuates stress response is neither straightforward nor universal.…”

Section: Oxytocin and Stressmentioning

confidence: 99%

“…Engelmann characterises this as the "Janus-faced" nature of OT whereby its effects are dualistic and contingent on personal circumstances (Engelmann et al, 2004).…”

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confidence: 99%

Oxytocin and Epstein‐Barr virus: Stress biomarkers in the postpartum period among first‐time mothers from São Paulo, Brazil

Rudzik¹,

Breakey²,

Bribiescas

2013

American J Hum Biol

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Citation for published item:udzikD el nn iFpF nd fre keyD eli i nd fri ies sD i h rd qF @PHIRA 9yxyto in nd ipsteinEf rr virus X stress iom rkers in the postp rtum period mong (rstEtime mothers from £ o uloD fr zilF9D emeri n journ l of hum n iologyFD PT @IAF ppF RQESHF Further information on publisher's website:httpXGGdxFdoiForgGIHFIHHPG jh FPPRVW Publisher's copyright statement: his is the epted version of the following rti leX udzikD el nn iFpF nd fre keyD eli i nd fri ies sD i h rd qF @PHIRA 9yxyto in nd ipsteinEf rr virus X stress iom rkers in the postp rtum period mong (rstEtime mothers from £ o uloD fr zilF9D emeri n journ l of hum n iologyFD PT @IAF ppF RQESHD whi h h s een pu lished in (n l form t httpXGGdxFdoiForgGIHFIHHPG jh FPPRVWF his rti le m y e used for nonE ommer i l purposes in ord n e ith iley erms nd gonditions for selfE r hivingF Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. 2 AbstractObjectives: The purpose of the study was to examine the relationship between selfreported stress levels among new mothers in São Paulo, Brazil and two biomarkers of stressful experience, oxytocin (OT) and Epstein-Barr Virus antibody level (EBV-ab), with planned pregnancy hypothesised as a moderator of biological response to stressful conditions. Methods: Sixty-three first-time mothers between the ages of 15 and 45 were recruited from neighbourhoods in São Paulo, Brazil. Quantitative and qualitative data were collected longitudinally, bi-weekly between two and 12 weeks postpartum. OT level was assessed from breast milk samples and EBV-ab from blood spot samples. An Interpersonal Satisfaction scale was developed, validated and administered, along with the Cohen Perceived Stress Scale (PSS). Results:In-depth interview data revealed unplanned pregnancy to be a significant stressor in the lives of first-time mothers. In linear regression, OT level was negatively associated with Interpersonal Satisfaction score (p=.022) and positively associated with PSS score (p=.007). When splitting the sample by planned status of the pregnancy, women with an unplanned pregnancy showed a strengthened positive association between OT level and PSS (p=.001; Adj R 2 =0.44) and negative association with Interpersonal Satisfaction (p=.017; Adj R 2 =0.15), while no associations existed for women with a planned pregnancy. EBV-ab level was not correlated or associated with stress/satisfaction measures. Conclusion:OT is an effective biomarker in the measurement of stress in the body, and additionally reflects differential experiences with difficul...

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Neurobiological Bases of Social Behavior across the Life Span

Porges

Carter

2010

The Handbook of Life‐Span Development

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The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited

Cited by 390 publications

References 152 publications

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Restoration of peripheral V2 receptor vasopressin signaling fails to correct behavioral changes in Brattleboro rats

Oxytocin and Epstein‐Barr virus: Stress biomarkers in the postpartum period among first‐time mothers from São Paulo, Brazil

Neurobiological Bases of Social Behavior across the Life Span

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