The Hypomania Checklist-32 and the Mood Disorder Questionnaire as screening tools — going beyond samples of purely mood-disordered patients

Meyer, Thomas D.; Bernhard, Britta; Born, Christoph; Fuhr, K; Gerber, Sonja; Schaerer, Lars; Langosch, Jens M.; Pfennig, Andrea; Sasse, Johanna; Scheiter, Susan; Schöttle, Daniel; Calker, Dietrich van; Wolkenstein, Larissa; Bauer, Michael

doi:10.1016/j.jad.2010.07.003

Cited by 38 publications

(21 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supporting lower specificity and higher sensitivity of HSL-32 compared with MDQ in diagnosing BD,52,53 our findings indicate HSL-32 and MDQ to reveal the likelihood of comorbid BD in 100.0% and 91.3% of patients, respectively, with confirmed diagnosis, while HSL-32 also revealed positive results in 70.1% of patients without BD. In fact, unipolar depressed patients have been suggested to have clinical features that resemble the type II BD patients in the presence of migraine, possibly indicating that migraine in depressed patients is a bipolar spectrum trait 54.…”

Section: Discussionmentioning

confidence: 56%

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Kıvılcım¹,

Altıntaş²,

Domaç³

et al. 2017

NDT

View full text Add to dashboard Cite

PurposeThe aim of this study was to evaluate the prevalence of comorbid bipolar disorder (BD) among migraineurs and the impact of migraine–BD comorbidity on disease characteristics.Patients and methodsA total of 120 adult patients diagnosed with migraine at a single tertiary care center were included in this cross-sectional study. Data on sociodemographic and migraine-related characteristics, family history of psychiatric diseases, comorbid psychiatric diseases, and first-episode characteristics were recorded. Mood Disorders Diagnosis and Patient Registration Form (SCIP-TURK), Mood Disorder Questionnaire (MDQ), and Hypomania Checklist-32-Revised (HCL-32-R) were applied to all patients by experienced clinicians, and clinical diagnoses were confirmed using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Migraine Disability Assessment Scale (MIDAS) was used to evaluate the headache-related disability. Study parameters were compared between migraineurs with and without comorbid BD.ResultsThe diagnosis of comorbid BD was confirmed in 19.2% of migraineurs. A significantly higher percentage of patients with comorbid BD than those without comorbid BD had family history of BD (39.1% vs 6.2%, P<0.001), suicide attempt (30.4% vs 5.2%, P<0.001), and physical abuse (52.2% vs 26.8%, P=0.019). MIDAS scores were significantly higher (50.6 [43.2] vs 33.8 [42.7], P=0.0422) in migraineurs with comorbid BD than in those without comorbid BD. Multivariate logistic regression model revealed that a positive family history of type I BD (odds ratio [OR], 14.42; 95% confidence interval [CI], 2.94–70.73; P=0.001) and MIDAS scores >30 (OR, 3.69; 95% CI, 1.12–12.19; P=0.032) were associated with 14.42 times and 3.69 times increased likelihood of BD, respectively.ConclusionOur findings revealed comorbid BD in a remarkable percentage of migraineurs and a higher likelihood of having BD in case of a positive family history of type I BD and MIDAS scores >30. Comorbid BD was associated with a higher rate for a family history of BD, suicide attempt, and childhood physical abuse as well as aggravated migraine-related disability among migraineurs. Migraineurs with and without comorbid BD showed similar sociodemographic and migraine disease characteristics as well as similar high rates for comorbid anxiety and first-episode depression.

show abstract

Section: Discussionmentioning

confidence: 56%

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Kıvılcım¹,

Altıntaş²,

Domaç³

et al. 2017

NDT

View full text Add to dashboard Cite

show abstract

“…This difficulty is compounded by the fact that depressive episodes predominate in the clinical course of BD‐I for most patients . Obtaining a collateral history from family members and medical records, and using screening instruments such as the Mood Disorders Questionnaire and the Hypomania Checklist‐32 increase the probability of detecting past hypomanias and manias. In patients with known BD, a clear change in illness course could be the consequence of organic pathology.…”

Section: Discussionmentioning

confidence: 99%

Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder

Satzer

Bond

2016

Bipolar Disorders

View full text Add to dashboard Cite

Secondary mania should be suspected in patients with neurological deficits, histories atypical for classic bipolar disorder, and first manic episodes after the age of 40 years. Treatment with antimanic medications, along with specific treatment for the underlying neurologic condition, is typically required. Typical lesion locations fit with current models of bipolar disorder, which implicate hyperactivity of left-hemisphere reward-processing brain areas and hypoactivity of bilateral prefrontal emotion-modulating regions. Lesion studies complement these models by suggesting that right-hemisphere limbic-brain hypoactivity, or a left/right imbalance, may be relevant to the pathophysiology of mania.

show abstract

“…[28,1,11,6,7]), a four-factor rather than a two-factor structure emerged. However, Holtmann et al [8], applying the HCL-32 with a sample of adolescents (mean age: 17.1 years), found a three-factor structure, with the first factor ''active-elated'' reflecting symptoms related to energy and activity.…”

Section: Discussionmentioning

confidence: 99%

The Farsi version of the Hypomania Check-List 32 (HCL-32): Applicability and indication of a four-factorial solution

et al. 2011

View full text Add to dashboard Cite

BackgroundData from the Iranian population for hypomania core symptom clusters are lacking. The aim of the present study was therefore to apply the Farsi version of the Hypomania-Check-List 32 (HCL-32), and to explore its factorial structure.MethodsA total of 163 Iranian out-patients took part in the study; 61 suffered from Major Depressive Disorder (MDD), and 102 suffered from Bipolar Disorders (BP). Participants completed the Mood Disorder Questionnaire (MDQ) and the Hypomania Checklist (HCL-32). Exploratory factor analyses were used to examine the properties of the HCL-32. A ROC-curve analysis was performed to calculate sensitivity and specificity.ResultsThe HCL-32 differentiated between patients with MDD and with BP. Psychometric properties were satisfactory: sensitivity: 73%; specificity: 91%. MDQ and HCL-32 did correlate highly. No differences were found between patients suffering from BP I and BP II.DiscussionInstead of the two-factorial structure of the HCL-32 reported previously, the present pattern of factorial results suggest a distinction between four factors: two broadly positive dimensions of hypomania ("physically and mentally active"; "positive social interactions") and two rather negative dimensions ("risky behavior and substance use"; "difficulties in social interaction and impatience").ConclusionThe Farsi version of the HCL-32 proved to be applicable, and therefore easy to introduce within a clinical context. The pattern of results suggests a four factorial solution.

show abstract

The Hypomania Checklist-32 and the Mood Disorder Questionnaire as screening tools — going beyond samples of purely mood-disordered patients

Cited by 38 publications

References 51 publications

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder

The Farsi version of the Hypomania Check-List 32 (HCL-32): Applicability and indication of a four-factorial solution

Contact Info

Product

Resources

About

The Hypomania Checklist-32 and the Mood Disorder Questionnaire as screening tools — going beyond samples of purely mood-disordered patients

Cited by 38 publications

References 51 publications

Screening for bipolar disorder among migraineurs: the impact of migraine&ndash;bipolar disorder comorbidity on disease characteristics

Screening for bipolar disorder among migraineurs: the impact of migraine&ndash;bipolar disorder comorbidity on disease characteristics

Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder

The Farsi version of the Hypomania Check-List 32 (HCL-32): Applicability and indication of a four-factorial solution

Contact Info

Product

Resources

About

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics

Screening for bipolar disorder among migraineurs: the impact of migraine–bipolar disorder comorbidity on disease characteristics