The hypolipidemic effect of Portulaca oleracea L. stem on hyperlipidemic Wister Albino rats

El-Newary, Samah A.

doi:10.1016/j.aoas.2016.01.002

Cited by 26 publications

(17 citation statements)

References 63 publications

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“…Saponins have been suggested to be involved in pancreatic lipase and adipogenesis inhibition (Marrelli et al, 2016). Flavonoids are phenolic compounds highly distributed in plants and exhibit several biological activities (Hügel et al, 2016) such as hypolipidemic properties due to plasmatic lipid lipolysis (El-Newary, 2016) or hypoglycemic activity by regeneration of damaged pancreatic islets, stimulate calcium and glucose uptake (Vinayagam and Xu, 2015;Zeka et al, 2017). Recently, a report on secondary metabolites of T. angustifolia was published, in which flavones are the flavonoids with biological effect (Sánchez-Chávez et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Salazar-Gómez

Vargas-Dı́az

Garduño‐Siciliano

2019

Bangladesh J Pharmacol

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The aim of the present study was to evaluate the hypoglycemic potential of Trixis angustifolia in alloxan-induced diabetic mice. An intragastric administration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of T. angustifolia was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explaining the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people. Article Info

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Section: Discussionmentioning

confidence: 99%

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Salazar-Gómez

Vargas-Dı́az

Garduño‐Siciliano

2019

Bangladesh J Pharmacol

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“…The hypolipidemic effect and reducing body weight gain have been reported for P. oleracea in animal models of hyperlipidemia. Different biochemicals such as polyphenols, phytosterols, alkaloids and saponins may be responsible for antihyperlipidemic effect of this plant through decreasing food intake, increasing gastrointestinal motility, promoting insulin sensitivity, regulating the cell energy metabolism or reducing free fatty acids, reducing cholesterol absorption through interfering with its enterohepatic circulation and increasing cholesterol fecal excretion (11,27).…”

Section: Discussionmentioning

confidence: 99%

Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

Safaeian¹,

Baniahmad²,

Esfandiari³

et al. 2017

J Herbmed Pharmacol

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The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasoneinduced hypertensive rats. Therefore, it is recommended that its using be avoided in hypertensive patients receiving glucocorticoids. Please cite this paper as: Introduction:Portulaca oleracea is used as a nutritional and medicinal plant. The aim of this study was to assess the effect of hydroalcoholic extract of P. oleracea seeds in dexamethasone -induced hypertension in rats. Methods: For induction of hypertension, dexamethasone (30 µg/kg/d, subcutaneously) was administered for 14 days. Animals received P. oleracea extract as a pretreatment at various doses of 100, 200 and 400 mg/kg/d orally from 4 days before dexamethasone administration and during the test period. Systolic blood pressure (SBP) and heart rate were measured using tailcuff method. The weight of thymus gland was estimated as a marker of glucocorticoid activity. Results: Dexamethasone injection significantly increased SBP (P < 0.001) while decreased the body and thymus weights (P < 0.05 and P < 0.001, respectively). Oral administration of P. oleracea could not prevent rising in SBP and decreasing in thymus weight. It also increased heart rate in hypertensive rats at the dose of 400 mg/kg/d (P < 0.05). Conclusion:The results of this study revealed that hydroalcoholic extract of P. oleracea seeds aggregates hypertension in dexamethasone-induced hypertensive rats. Hence, it should be used with caution in hypertensive patients receiving glucocorticoids.

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“…Histopathology of the mid-gut was based on a published method with minor modifications (Selin-Rani et al 2016;Pradeepa et al 2015). The treated and untreated larvae were cut through the cuticle longitudinally and fixed in 4% formaldehyde.…”

Section: Histopathology Studymentioning

confidence: 99%

“…[3][4][5][6] All parts of purslane were verified to have some bioactivities. For example, the contents of the stem exhibited an anti-hypolipidemic effect, 7 its seeds were treated to be a remedy for diabetes mellitus type II, 8 and the ethyl acetate extract of purslane leaves improved immunosuppression of cyclophosphamidum in ICR mice. 9 Purslane was listed as an important insecticidal plant in Chinese Folk Pesticide Plant Record.…”

Section: Introductionmentioning

confidence: 99%

A homoisoflavonoid and a fatty acid in common purslane (Portulaca oleracea L.) synergistically inhibit growth of Spodoptera litura larvae

Wang

Yang

et al. 2019

Pest Management Science

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BACKGROUND Portulaca oleracea L., common purslane, is an insecticidal plant that has been documented as a ‘Chinese indigenous pesticide’, and it is seldom visited by insects in the field. However, identification of anti‐insect compounds and mechanisms of action are still unclear. RESULTS Interplanting purslane with Chinese cabbage demonstrated that purslane may contain secondary compounds that S. litura avoids eating. Four compounds were isolated from P. oleracea by directed anti‐insect activity, and their chemical structures were identified by NMR spectra as (9Z,11E,15Z)‐13‐hydroxyoctadeca‐9,11,15‐trienoic acid (1), portulacanone A (2), portulacanone D (3), and a new natural product 2,4′‐dihydroxy‐3′,5′‐dimethoxychalcone (4). A combination of compound 1 and 2 possessed stronger activity than other combinations (compounds 1 + 3; 1 + 4; 2 + 3; 2 + 4; 3 + 4). Both active compounds were detected in all samples from 23 regions in China, and concentrations in samples collected from 17 regions were generally above 500 μg/kg. Concentrations of compounds 1 and 2 fluctuated greatly from April to November, and reached maximum concentrations of 45 951.44 μg/kg for compound 1 and 3739.09 μg/kg for compound 2 in November. The combination of these compounds (1 + 2) caused mid‐gut structural deformation and tissue decay as determined by mid‐gut histopathology of S. litura. CONCLUSION In general, these active compounds coexisting contributed to partly protect purslane from insects. This research also provides new insights into the use of purslane as important ingredient of botanical pesticide alternatives to traditional chemical pesticides. © 2019 Society of Chemical Industry

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The hypolipidemic effect of Portulaca oleracea L. stem on hyperlipidemic Wister Albino rats

Cited by 26 publications

References 63 publications

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Portulaca oleracea seeds extract does not prevent dexamethasone-induced hypertension in rats

A homoisoflavonoid and a fatty acid in common purslane (Portulaca oleracea L.) synergistically inhibit growth of Spodoptera litura larvae

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