Hypoglycemic potential of Trixis angustifolia aqueous extract in alloxan-induced diabetic mice

Abstract

The aim of the present study was to evaluate the hypoglycemic potential of Trixis angustifolia in alloxan-induced diabetic mice. An intragastric administration of the aqueous extract (50, 100 and 200 mg/kg) prepared from the aerial parts of T. angustifolia was evaluated. The treatment with the extract at 100 mg/kg produced a significant lowered (30.5%) of the blood glucose levels in diabetic mice after 15 days of daily oral administration. In addition, the extract induced a significant decrease in serum total cholesterol, low density lipoprotein whereas increased the high-density lipoprotein level. Additionally, the presence of alkaloids, cumarins, saponins, flavonoids and reducing sugars were identified in the extract. These findings provide a basis explaining the traditional folk medicine use of this plant as a hypoglycemic agent by the Mexican people. Article Info

Phytochemical analysis, cytotoxic, antioxidant and anti-diabetic activities of the aerial parts of Sorghum halepense

“…The anti-diabetic activities of Achillea santolina (Grover et al, 2002), Adiantum capillus-veneris (Al-Snafi, 2013), Agrimony eupatoria (Al-Snafi, 2015), Aristolochia longa (El Omari et al, 2019), Atractylis gummifera (Bouabid et al, 2019), Eruca sativa (Kishore et al, 2017), Gaultheria trichophylla (Alam and Saqib, 2017), Leucas aspera (Annapandian and Sundaram, 2017), Myrica gale, Rhodiola rosea, Rumex acetosa, Taraxacum officinale (Sekhon-Loodu and Rupasinghe, 2019), Trixis angustifolia (Salazar-Gómez et al, 2019) and Urtica dioica (Ahangarpour et al, 2012) have been reported. um phosphate dibasic, DPPH (2, 2-diphenyl-1-picrylhydrazyl), ABTS•+ (2,2-azinobis (3-ethyl-benzothiazoline)-6-sulfonic acid disodium salt), hydrogen peroxide, amylase, DNS (dinitrosalicylic) acid, sea salts, glucophage, potassium persulfate were of analytical grade.…”

Hypolipidemic Effect ofTrixis angustifoliaAqueous Extract on Triton WR-1339- and High-Fat Diet-Induced Hyperlipidemic Mice

“…5 In traditional Mexican medicine, the aerial parts of T. angustifolia have been used as a water-extract formulation to reduce blood glucose in alloxan-induced diabetic mice. 6 However, there is no literature about the hypolipidemic activity of this species that supports the ethnomedical usage of the plant. Therefore, the present study was conducted to evaluate the hypolipidemic effect of T. angustifolia aqueous extract (TxAE) on Triton WR-1339- and high-fat diet-induced hyperlipidemic mice.…”

“…As far as we know, there is only 1 phytochemical screening regarding the use of water as solvent for the extraction of T. angustifolia constituents. 6 This is important since popular use occurs more frequently with infusions, decoctions, and macerations, and little is known about the constitution of this kind of extract. Thus, as part of the phytochemical study, we have determined the phenolic composition of TxAE.…”