The hyperglycemic regulatory effect of sprouted quinoa yoghurt in high-fat-diet and streptozotocin-induced type 2 diabetic mice <i>via</i> glucose and lipid homeostasis

Ujiroghene, Obaroakpo Joy; Nan, Wenlong; Hao, Liyu; Liu, Lu; Zhang, Shuwen; Lu, Jianwei

doi:10.1039/d0fo01575j

Cited by 37 publications

(22 citation statements)

References 48 publications

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“…The AKT signaling pathway takes on a critical function in regulating glucose metabolism and insulin resistance (Huang et al., 2018). And the AMPK signaling pathway controls various metabolic dysfunction, including lipid metabolism in T2D (Obaroakpo et al., 2020). The results revealed that, compared with normal mice, p‐IRS‐1, p‐AKT, and p‐GSK3β levels were markedly decreased by 42.90%, 30.56%, and 54.17% in T2D mice, although these effects were reversed by 78.02%, 19.08%, and 129.30% following high‐dose AAPs administration (Figure 8a–d).…”

Section: Resultsmentioning

confidence: 99%

Auricularia auricula‐judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ‐induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota

Zhou

et al. 2021

Journal of Food Science

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Auricularia auricula‐judae is an edible fungus with high nutritional value due to abundant polysaccharides, and is acknowledged as traditional food and medicine in Asia. Polysaccharides from A. auricula (AAPs) are typically fungal polysaccharides and have a wide range of biological activities. It has been shown the potential of AAPs to improve diabetes as an effective adjuvant, but the underlying mechanism remains unclear. In this study, we explored the effects and potential mechanism of AAPs on type 2 diabetes (T2D) using a high‐fat diet and streptozotocin (STZ) induced C57BL/6J mice. The results indicated that 50 and 100 mg/kg AAPs significantly decreased inflammation, liver injury, and insulin resistance. In addition, AAPs improved glycolipid metabolism disorders by activating the AKT and adenosine 5`monophosphate‐activated protein kinase (AMPK) signaling pathways in T2D mice. Furthermore, we investigated the association between changes of gut microbiota and AAPs effects using high‐throughput sequencing of 16S rDNA for fecal samples. In our study, AAPs elevated gut microbiota diversity and optimized microbial composition and function in T2D mice, characterized by increased Lactobacillus and Bacteroides abundance and decreased Clostridium and Allobaculum abundance. Particularly, AAPs intervention mainly affected the amino acid metabolism and glycolipid metabolism pathways. Overall, this study confirms that AAPs can improve type 2 diabetes by regulating the AKT and AMPK pathways and modulating intestinal microbiota. Practical Application The article systematically verified the positive effects of AAPs on insulin resistance, glycolipid metabolism disorder, inflammation, and liver injury, key factors closely related to T2D. Furthermore, our study firstly determined the specific underlying mechanism that AAPs ameliorates T2D through regulating AKT/AMPK pathways and modifying the gut microbiota. These results could offer a full explanation and a potential option for the adjuvant therapy of diabetes with AAPs.

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Section: Resultsmentioning

confidence: 99%

Auricularia auricula‐judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ‐induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota

Zhou

et al. 2021

Journal of Food Science

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“…There is current interest in encouraging the consumption of quinoa since a number of recent studies have shown beneficial effects on biomarkers of cardiovascular disease risk (e.g. Li et al, 2018;Pourshahidi et al, 2020;Obaroakpo et al, 2020;Karimian et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Phenolic, apparent antioxidant and nutritional composition of quinoa (Chenopodiumquinoa Willd.) seeds

Seal

2021

Int J of Food Sci Tech

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Quinoa, a gluten-free pseudocereal, has a nutrient and phytochemical profile which may benefit health. Our aim was to investigate the variability in the phenolic and apparent antioxidant content of different quinoa varieties to identify a variety with a high phytochemical content to use in a quinoa-enriched bread. The results showed that free phenolics contributed most (50-83%) to total phenolic content compared with conjugated or bound forms. Apparent antioxidant activities measured by FRAP, ABTS+• and DPPH of free, conjugated and bound extracts were broadly similar, except for free antioxidants when determined by FRAP, which were higher. Phenolic content was positively correlated with FRAP and ABTS+• apparent antioxidant activity. Quinoa samples had a high protein content (13.5 g/100 g dry weight), with a well-balanced amino acid profile. Incorporation of quinoa into baked products such as bread is proposed as a way to deliver this healthy whole-grain cereal into the diet.

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“…Diabetes mellitus is a metabolic disease resulting from insulin resistance and characterized by hyperglycemia (Obaroakpo et al., 2020). By 2040, more than 6.42 million people are expected to develop this disease (Herman, 2017).…”

Section: Introductionmentioning

confidence: 99%

Effects of L‐arabinose by hypoglycemic and modulating gut microbiome in a high‐fat diet‐ and streptozotocin‐induced mouse model of type 2 diabetes mellitus

Shen

Tian

et al. 2021

J Food Biochem

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L‐arabinose is a good and healthy food additive. This study was conducted to investigate the effect of L‐arabinose in a mouse model of type 2 diabetes mellitus (T2DM) induced by exposure to a high‐fat diet (HFD) and streptozotocin (STZ). The model mice received L‐arabinose at 20 and 60 mg (kg body weight [bw])−1d−1, metformin at 300 mg (kg bw)−1d−1 (positive control) or sterile water (control) via oral gavage. Compared with the model group, mice treated with L‐arabinose exhibited attenuated symptoms of diabetes mellitus, including a slower rate of body weight loss, increased homeostasis model assessment of β‐cell function index levels, decreased blood glucose, alleviation of steatosis, and repair of pancreatic islet cells. L‐arabinose also exerted an anti‐inflammatory effect and partially mitigated dyslipidemia. A 16S‐rRNA sequence analysis of the gut microbiota revealed that at the phylum level, treatment with L‐arabinose significantly reduced the ratio of Firmicutes to Bacteroidetes due to a decreased relative abundance of Firmicutes; at the genus level, it reversed the increase in the relative abundance of Allobaculum and the decrease abundance of Oscillospira caused by exposure to an HFD and STZ. And the model mice received L‐arabinose at 20 mg (kg bw)−1d−1 had a better effect on improving T2DM than the high‐dose group supplemented L‐arabinose at 60 mg (kg bw)−1d−1. These results strongly suggest L‐arabinose as an excellent candidate supplement to prevent or treat T2DM. Practical applications L‐arabinose, xylitol and sucralose are well‐known substitutes for sucrose. L‐arabinose has been reported to have beneficial effects on hyperglycemia, glycemic index, and fat accumulation. In this study, we found that low‐dose (20 mg (kg bw)−1d‐1) supplementation of L‐arabinose significantly improved glucose intolerance and gut microbiota incoordination in T2DM caused by HFD and STZ.

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The hyperglycemic regulatory effect of sprouted quinoa yoghurt in high-fat-diet and streptozotocin-induced type 2 diabetic mice via glucose and lipid homeostasis

Abstract: Recently, we have proposed that quinoa yoghurt (QY) has the anti-diabetic properties based on an in vitro study.

Cited by 37 publications

References 48 publications

Auricularia auricula‐judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ‐induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota

Auricularia auricula‐judae (Bull.) polysaccharides improve type 2 diabetes in HFD/STZ‐induced mice by regulating the AKT/AMPK signaling pathways and the gut microbiota

Phenolic, apparent antioxidant and nutritional composition of quinoa (Chenopodiumquinoa Willd.) seeds

Effects of L‐arabinose by hypoglycemic and modulating gut microbiome in a high‐fat diet‐ and streptozotocin‐induced mouse model of type 2 diabetes mellitus

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