The hypercoagulable status in common <scp>M</scp>editerranean β‐thalassaemia mutations trait

Labib, Hany A.; Etewa, Rasha L.; Atia, Hesham

doi:10.1111/ijlh.12289

Cited by 3 publications

(5 citation statements)

References 30 publications

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“…The haemolysis associated with ineffective erythropoiesis in HBT is much milder [26]. Coagulation activation has been reported in HBT as well [27]. The higher MPV in patients with HBT may also be an indicator of platelet activation, thus being compatible with the observation of coagulation activation in HBT [27].…”

Section: Discussionmentioning

confidence: 79%

“…Coagulation activation has been reported in HBT as well [27]. The higher MPV in patients with HBT may also be an indicator of platelet activation, thus being compatible with the observation of coagulation activation in HBT [27]. As the factor causing coagulation activation in HBT is mild haemolysis, it could be that this is overcome by congenital or acquired platelet dysfunction, and thrombotic events may occur less frequently in patients with HBT compared to in the general population [2,14,26].…”

Section: Discussionmentioning

confidence: 99%

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Mean Platelet Volume in Heterozygous Beta Thalassaemia

Çıkrıkçıoğlu¹,

Çelik²,

Ekinci³

et al. 2017

Acta Haematol

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Background/Aim: It is not known why cerebrovascular and cardiovascular ischaemic events are less frequently observed in heterozygous beta thalassaemia (HBT) patients than in the general population. However, we previously reported that serum levels of some platelet function markers, i.e. soluble CD40 ligand and soluble P-selectin, are lower in patients with HBT than in controls. A high mean platelet volume (MPV) is an indicator of in vivo platelet activation and may indicate a tendency to thrombosis. We investigated whether MPV is lower in HBT patients than in controls. Methods: Forty-eight patients with HBT were compared with 51 controls matched for gender, age, and BMI for MPV in a cross-sectional study. Results: The MPV was within the normal range and higher in the HBT group (9.64 ± 1.20 vs. 9.07 ± 082 fL, p = 0.006). The 2 groups were similar in terms of atherosclerosis risk factors and medications. After linear regression analysis, the MPV was correlated with HBT, sensitive CRP, and BMI. Conclusion: The higher MPV in patients with HBT could indicate platelet activation, and this may represent a dilemma. Higher MPV in the HBT group might have resulted from higher sympathetic nervous system activity, mild ineffective erythropoiesis, and haemolysis.

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Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Mean Platelet Volume in Heterozygous Beta Thalassaemia

Çıkrıkçıoğlu¹,

Çelik²,

Ekinci³

et al. 2017

Acta Haematol

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“…Furthermore, the right OA more commonly arises from the ICA than the left OA according to previous studies [ 2 ]. Even though thalassemia minor was associated with hypercoagulable status through laboratory test, as reported by Labib et al [ 6 ], different studies showed a reduced risk of cerebral and cardiovascular events in these patients. This protective effect was explained by low pressure value, low blood viscosity and low cholesterol levels [ 7 ].…”

Section: Discussionmentioning

confidence: 81%

Minor stroke with bilateral acute infarctions and combined vascular anomalies: A complex case report

Giammello

Dell’Aera

Grillo

et al. 2020

Heliyon

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We report the case of a patient with bilateral acute ischemic lesions (AIS) in middle cerebral artery (MCA) territory associated with an extremely rare combination of anomalies of the aortic arch and the left internal carotid artery (ICA). The diagnosis deposed for bilateral minor embolic stroke of undetermined source (ESUS), inpatient with patent foramen ovale (PFO) and positive antiphospholipid (aPL) test. To our knowledge, this is the first description of a patient with this rare combination of vascular anomalies.

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“…[28] Chandra et al [29] found an interesting point that has to be highlighted in the study is that apart from red cell parameter, platelet parameters including platelet counts, platecrit, and MPV also showed statistical significant difference between IDA and BTC. In another study, Labib et al [11] found no significant difference as regard platelet counts but a significant higher MPV was found in BTC subjects compared with controls. On the other hand, Cikrikcioglu et al [12] found in the study that, the MPV levels were unexpectedly higher in patients in the BTC group than in the control group.…”

Section: Discussionmentioning

confidence: 84%

“…[7][8][9] Several studies reported an inverse relationship between mean platelet volume (MPV) and platelet counts in patients with BTC. [10][11][12] This may be related to morphological features of platelets. In the literature, there are also some informations about platelet indices in BTC.…”

Section: Introductionmentioning

confidence: 99%

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers

Akbayram

Örkmez

2020

Journal of Contemporary Medicine

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Aim: β-thalassemia carriers (BTC) is generally asymptomatic; however, in clinical practice, there is hypochromic microcytic mild anemia caused by a hereditary reduction in beta globin synthesis. In the literature, there is also some information about platelet indices in BTC. The aim of this study was to evaluate platelet indices in children with BTC. In addition, we compared platelet indices between anemia (Hb<11 g/dl) and non-anemia BTC (Hb ≥11 g/dl). Material and Method: A cross sectional study included a total of 153 subjects aged 1-16 years were recruited from Gaziantep University Hospital outpatient clinics electronic database. Results: Platelet counts were normal in 90 patients with BTC. Thrombocytosis and thrombocytopenia were detected in 59 (38.5%) and four (2.6%) patients, respectively. This study group was divided into two groups as group 1, cases<11 g/dl (n=86), and group 2, cases≥11g/dl (n=67) according to the hemoglobin levels. The children with the group 1 had significantly higher mean levels of platelet counts and platecrit than those with group 2 (p<0.05). In the logistic regression test, linear correlation between platelet counts and platecrit (r=0.94, p<0.01) was observed, whereas there were inverse correlations between platelet counts and age (r=-0.32, p<0.01), mean platelet volume (r=-0.18, p<0.05), hemoglobin (r =-0.18, p<0.05). Conclusion: We found that both thrombocytosis and thrombocytopenia may occur in BTC. Herein we also found significantly elevated platelet counts in BTC with anemia.

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The hypercoagulable status in common Mediterranean β‐thalassaemia mutations trait

Abstract: BTT subjects may have a risk of hypercoagulable state particularly in β0 genotype. Measurement of PS exposure on RBCs and the plasma F1+2 is useful to evaluate hypercoagulability state.

Cited by 3 publications

References 30 publications

Mean Platelet Volume in Heterozygous Beta Thalassaemia

Mean Platelet Volume in Heterozygous Beta Thalassaemia

Minor stroke with bilateral acute infarctions and combined vascular anomalies: A complex case report

Relationship between platelet counts, mean platelet volume, platecrit and Beta Thalassemia Carriers

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