The “humble” bubble: Contrast-enhanced ultrasound

Marshall, Gill; Sykes, Anne E.; Berry, Jonathan; Jonker, Leon

doi:10.1016/j.radi.2011.05.002

Cited by 12 publications

(11 citation statements)

References 40 publications

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“…These techniques may not be necessary for global abnormalities such a complete testicular infarction. While CEUS has an excellent safety profile [15,13], anaphylactic reactions have been documented hence, prompt access to resuscitation equipment should be available [12,14].…”

Section: Scrotal Ceus Techniquementioning

confidence: 99%

“…The technique can be performed in patients with renal impairment and needs no prior laboratory testing. Moreover, UCA have a lower risk of adverse reactions compared to the contrast agents currently used in computed tomography (CT) and magnetic resonance imaging (MRI) [13][14][15]. CEUS is also cost-effective, quick, portable and repeatable safely with multiple injections, all without radiation exposure [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

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The role of contrast-enhanced ultrasound (CEUS) in the evaluation of scrotal trauma: a review

et al. 2020

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Testicular trauma is common, usually trivial and rarely requires hospital attendance, but if it does, then imaging becomes essential as scrotal assessment may be difficult due to pain and/or scrotal disruption. Ultrasound (US) assumes a crucial role as other cross-sectional modalities have a limited use in the acute presentation. Despite the acceptable accuracy of conventional US techniques, there are limitations which hinder a thorough evaluation, critically the assessment of tissue viability, crucial for clinical management and prognosis. Contrast-enhanced ultrasound (CEUS) has been shown to offer improved flow visualisation and tissue perfusion compared with conventional Doppler techniques. CEUS can accurately and confidently demonstrate the viability of testicular parenchyma, delineate fracture lines and haematomas and guide treatment for testis-sparing surgery or orchidectomy. The purpose of this review is to present the literature, familiarise physicians with the principles of CEUS and findings of scrotal trauma and illustrate the main abnormalities through characteristic and educative cases.

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Section: Scrotal Ceus Techniquementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The role of contrast-enhanced ultrasound (CEUS) in the evaluation of scrotal trauma: a review

et al. 2020

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“…This is done by using positron emission tomography, single‐photon emission computed tomography, magnetic resonance imaging, and computed tomography with contrast agents, which provide degrees of functional and morphologic imaging . However, these imaging modalities are often expensive, involve radiation exposure, or may not be accessible at all health care and research institutions …”

Section: Number Of Primary Articles and Functions Of More Commonly Stmentioning

confidence: 99%

Scoping Review of Targeted Ultrasound Contrast Agents in the Detection of Angiogenesis

Lau¹,

Rivas²,

Dinalo

et al. 2019

J of Ultrasound Medicine

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A systematic search was conducted to categorize targeted ultrasound contrast agents (UCAs) used in cancer-related angiogenesis detection. We identified 15 unique contrast agents from 2008 to March 2018. Most primary research articles studied UCAs targeted to vascular endothelial growth factor receptor or α v β 3 -integrin. Breast cancer and colon cancer are the most common neoplastic processes in which these agents were studied. BR55 (Bracco Research SA, Geneva, Switzerland), a vascular endothelial growth factor receptor-targeting UCA, is the first targeted UCA that has completed phase 0 trials. Our review identifies a gap in the literature regarding the application of targeted UCAs in cancer models beyond breast and colon cancers and identifies other promising UCAs.

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“…space 5 which allows them to be well suited for detecting and monitoring disease that could be characterized by a differential expression of molecules on the vasculature.…”

mentioning

confidence: 99%

“…Contrastenhanced ultrasound therefore is advantageous compared with other forms of molecular imaging, because images can be obtained rapidly, in real time, without the need for postprocessing. 5 The goal of this scoping review was to examine the extent, range, and nature of research on the use of targeted UCAs, specifically in the detection of cardiac ischemia. Innovative targeted contrast agents can potentially allow the noninvasive detection and evaluation of the ischemic response on a molecular scale.…”

mentioning

confidence: 99%

Scoping Review of Targeted Ultrasound Contrast Agents in the Detection of Myocardial Ischemia

Lau

Hess

Shreves

et al. 2020

Journal of Diagnostic Medical Sonography

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Objective: A systematic search was conducted to categorize targeted ultrasound contrast agents used in the detection of myocardial ischemia. Methods: The search identified 14 primary research articles published from 2000 to August 2019 that fulfilled the selection criteria. All studies were conducted in animal models ranging from mice to rhesus monkeys, with the most common targets being P-selectin and E-selectin. Results: These studies show that targeted ultrasound contrast agents produced greater signal enhancement in regions with prolonged ischemia and maintained enhancement hours after reperfusion. Conclusion: This review identified gaps in the literature, such as a need for comparative studies among different molecular markers and between current standard of care with the use of targeted contrast agents in cardiac ultrasound.

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The “humble” bubble: Contrast-enhanced ultrasound

Cited by 12 publications

References 40 publications

The role of contrast-enhanced ultrasound (CEUS) in the evaluation of scrotal trauma: a review

The role of contrast-enhanced ultrasound (CEUS) in the evaluation of scrotal trauma: a review

Scoping Review of Targeted Ultrasound Contrast Agents in the Detection of Angiogenesis

Scoping Review of Targeted Ultrasound Contrast Agents in the Detection of Myocardial Ischemia

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