Abstract:A systematic search was conducted to categorize targeted ultrasound contrast agents (UCAs) used in cancer-related angiogenesis detection. We identified 15 unique contrast agents from 2008 to March 2018. Most primary research articles studied UCAs targeted to vascular endothelial growth factor receptor or α v β 3 -integrin. Breast cancer and colon cancer are the most common neoplastic processes in which these agents were studied. BR55 (Bracco Research SA, Geneva, Switzerland), a vascular endothelial growth fact… Show more
“…The CEUS is a common method for the detection of angiogenesis, and targeted ultrasound contrast agents can produce stronger signals associated with angiogenesis. 27 The PAI technique is based on a combination of laser and ultrasound, which is particularly suitable for visualization of microvasculature due to high optical absorption of hemoglobin; it has proven valuable for monitoring neovascularization in tissue engineering. 28 The PAM is a new method for in vivo imaging of the microvasculature using high contrast and deep penetration, and has great potential for biomedical research.…”
“…The CEUS is a common method for the detection of angiogenesis, and targeted ultrasound contrast agents can produce stronger signals associated with angiogenesis. 27 The PAI technique is based on a combination of laser and ultrasound, which is particularly suitable for visualization of microvasculature due to high optical absorption of hemoglobin; it has proven valuable for monitoring neovascularization in tissue engineering. 28 The PAM is a new method for in vivo imaging of the microvasculature using high contrast and deep penetration, and has great potential for biomedical research.…”
“…Novel contrast agents for these markers can enable visualization of disease at the molecular level and provide invaluable insight on early diagnosis of malignancy. 11 Through the iterative process of conducting a scoping review, we have identified other novel applications of ultrasound microbubbles outside the realm of diagnostics. Ultrasound microbubbles can be used therapeutically in drug delivery and treatment.…”
Objective: A systematic search was conducted to categorize targeted ultrasound contrast agents used in the detection of myocardial ischemia. Methods: The search identified 14 primary research articles published from 2000 to August 2019 that fulfilled the selection criteria. All studies were conducted in animal models ranging from mice to rhesus monkeys, with the most common targets being P-selectin and E-selectin. Results: These studies show that targeted ultrasound contrast agents produced greater signal enhancement in regions with prolonged ischemia and maintained enhancement hours after reperfusion. Conclusion: This review identified gaps in the literature, such as a need for comparative studies among different molecular markers and between current standard of care with the use of targeted contrast agents in cardiac ultrasound.
“…Angiogenesis plays a vital role in assessing atheroma plaque progression deposited between the vascular walls; there is also a correlation between atherosclerosis and angiogenesis. 79 In this regard, several markers activated on endothelial cells, including integrin (a v b 3 ) and vascular endothelial growth factor (VEGFR-2) conjugated with MBs as contrast-enhanced ultrasound agents, have been developed. It has been shown that the mean pixel intensity (MPI) of VEFR-2@ MBs as CEUS is higher than targeted a v b 3 in the detection of angiogenesis.…”
Section: Reviewmentioning
confidence: 99%
“…Angiogenesis plays a vital role in assessing atheroma plaque progression deposited between the vascular walls; there is also a correlation between atherosclerosis and angiogenesis. 79…”
Section: Application Trends Of Uscas In the Diagnosis Of Diseasesmentioning
Ultrasound (US) imaging, due to its capabilities in real-time imaging, portability, low-cost, and favorite safety, is frequently used as a diagnostic modality for visualization of different diseases. US imaging is...
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