The human trigeminal ganglion: c-kit positive neurons and interstitial cells

Rusu, Mugurel Constantin; Pop, F.; Hostiuc, Sorin; Dermengiu, Dan; Lală, Adrian; Ion, Daniela Adriana; Mănoiu, Vasile Sorin; Mirancea, Nicolae

doi:10.1016/j.aanat.2011.06.005

Cited by 28 publications

(23 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In such niches a distinctive class of stromal cells, the telocytes, usually positive for CD117/c-kit, were found "nursing" the stem cells [20]. Such c-kit-positive interstitial cells were also described in the human adult trigeminal ganglion [25].…”

Section: Discussionmentioning

confidence: 82%

“…The general basic concept in which the trigeminal ganglion is defined as comprising neurons and glial cells [25] could be updated to include PCs. The morphological and immune phenotypes of these progenitor cells should be firmly correlated, in order to facilitate quantitative experiments.…”

Section: Discussionmentioning

confidence: 99%

“…The later envelop the sensory neurons to form neurono-glial functional units [1][2][3] in which the SGCs interact with neurons through gap junctions [4] and in a paracrine manner [5][6][7]. In TEM was found that the neuronal envelopes also include interstitial cells with morphologies allowing them to be considered telocytes [8].…”

Section: Introductionmentioning

confidence: 99%

“…The ultrastructure of SGCs includes polysomes, rough endoplasmic reticulum, Golgi apparatus, lysosomes, multivesicular bodies, autophagic vacuoles, microtubules and intermediate filaments [8].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Quiescent satellite glial cells of the adult trigeminal ganglion

Rusu¹,

Mănoiu

Mirancea

et al. 2014

Open Medicine

View full text Add to dashboard Cite

AbstractSensory ganglia comprise functional units built up by neurons and satellite glial cells (SGCs). In animal species there was proven the presence of neuronoglial progenitor cells in adult samples. Such neural crest-derived progenitors were found in immunohistochemistry (IHC). These findings were not previously documented in transmission electron microscopy (TEM). It was thus aimed to assess in TEM if cells of the human adult trigeminal ganglion indeed have ultrastructural features to qualify for a progenitor, or quiescent phenotype. Trigeminal ganglia were obtained from fifteen adult donor cadavers. In TEM, cells with heterochromatic nuclei, a pancytoplasmic content of free ribosomes, few perinuclear mitochondria, poor developed endoplasmic reticulum, lack of Golgi complexes and membrane trafficking specializations, were found included in the neuronal envelopes built-up by SGCs. The ultrastructural pattern was strongly suggestive for these cells being quiescent progenitors. However, further experiments should correlate the morphologic and immune phenotypes of such cells.

show abstract

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quiescent satellite glial cells of the adult trigeminal ganglion

Rusu¹,

Mănoiu

Mirancea

et al. 2014

Open Medicine

View full text Add to dashboard Cite

show abstract

“…In most tissues, CD117 is only expressed on the surface of ICCs of the gut, in telocytes of various organs, and in mast cells and some neurons within the trigeminal ganglion (Rusu et al 2011). Double immunolabeling is very important for the differential diagnosis of telocytes from other interstitial cells, and can be used in both tissues and in vitro cell cultures.…”

Section: Immunohistochemical Identification Of Cardiac Telocytesmentioning

confidence: 99%

The functional morphology and role of cardiac telocytes in myocardium regeneration

Varga

Danišovič

Kyselovič

et al. 2016

Can. J. Physiol. Pharmacol.

View full text Add to dashboard Cite

Anoctamin 1 Positive Esophageal Interstitial Cajal Cells in Late Stage Human Embryos

Rusu

Poalelungi

Vrapciu

et al. 2013

The Anatomical Record

View full text Add to dashboard Cite

Interstitial cells of Cajal (ICCs) are located in various smooth muscle organs and act as pacemaker cells, or ensure neuromodulation or mechanosensory roles. The study aims to investigate functional states of human ICCs in morphogenesis, focusing on the anoctamin 1 phenotype. The investigation was performed in five late stage human embryos with lengths varying between 23 and 29 mm. Immunohistochemistry on paraffin embedded specimens was performed for a series of antibodies: a-smooth muscle actin (a-SMA), desmin, CD31, CD34, CD117/c-kit, DOG1, and nestin. Longitudinal and circular muscle layers were a-SMA1/desmin1/nestin1. An immature microvascular layer located in the inner submucosa was CD341/CD311/a-SMA1/ nestin1; endothelial tip cells were supporting active processes of sprouting angiogenesis. A CD341/CD31-mesenchymal network was found in the circular muscle layer. CD117/c-kit1 multipolar ICCs with dichotomizing processes were found mostly in the myenteric plexus layer; processes were configuring a network within the circular muscle layer where intramuscular ICCs were scarcely found. A strong DOG11 reaction was found for the ICCs of the myenteric plexus layer apposed on the outer surface of the circular muscle layer, and for the intramuscular ICCs.

show abstract

The human trigeminal ganglion: c-kit positive neurons and interstitial cells

Cited by 28 publications

References 59 publications

Quiescent satellite glial cells of the adult trigeminal ganglion

Quiescent satellite glial cells of the adult trigeminal ganglion

The functional morphology and role of cardiac telocytes in myocardium regeneration

Anoctamin 1 Positive Esophageal Interstitial Cajal Cells in Late Stage Human Embryos

Contact Info

Product

Resources

About