The functional morphology and role of cardiac telocytes in myocardium regeneration

Varga, Ivan; Danišovič, Ľuboš; Kyselovič, Ján; Gažová, Andrea; Musil, Peter; Miko, M; Polák, Štefan

doi:10.1139/cjpp-2016-0052

Cited by 20 publications

(17 citation statements)

References 52 publications

(35 reference statements)

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“…It is possible that cell‐cell contacts with different morphologies exist but have not been described yet. When telocytes make contact with other cells, these heterocellular contacts are also regularly characterized as “atypical junctions” whose ultrastructural features do not match any of the classical junctions (Gherghiceanu & Popescu, ; Varga et al., ). They are often minute junctions, meaning these are very small contacts ( point contacts , planar contacts and nanocontacts ) with a mean intermembrane distance of 10–30 nm which is within the macromolecular interaction range (Faussone‐Pellegrini & Gherghiceanu, ).…”

Section: Discussionmentioning

confidence: 99%

Identification of telocytes in the porcine heart

Tay

Vandecasteele

Broeck

2017

Anat Histol Embryol

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Recently, a new interstitial cell type called telocyte has been identified. Telocytes are found in many organs including the heart, where they are especially well described. However, their presence in the porcine heart has not yet been proven. The pig is a valuable animal model in research because of its resemblance with man, making it interesting to determine whether telocytes can be found in pigs as well. The focus of this study is the identification and ultrastructural description of telocytes in the heart tissue of pig. Using transmission electron microscopy, telocytes were found in both left and right atrium and ventricle, usually close to cardiomyocytes and/or blood vessels. Their most important characteristic is the long cytoplasmic processes called telopodes, which have a moniliform aspect, measure tens of μm and usually have a thickness below 0.2 μm. This unique morphological feature enables telocytes to be recognized from other interstitial cells such as fibroblasts. Additional observations include the ability to release extracellular vesicles and to make contacts with other structures such as endothelial cells, suggesting a role in intercellular communication.

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Section: Discussionmentioning

confidence: 99%

Identification of telocytes in the porcine heart

Tay

Vandecasteele

Broeck

2017

Anat Histol Embryol

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“…Adding to the confusion of understanding the cardiac fibroblast is the use of many different terms including: fibrocyte 8,9 , telocyte 10 , myofibroblast 11 , protomyofibroblast 12 , mesenchymal cell, and stromal cell. Each of these categories reflects a definition that varies depending on the author and demonstrates a lack of consensus regarding these cells.…”

Section: Cardiac Fibroblast Identitymentioning

confidence: 99%

Defining the Cardiac Fibroblast

Ivey

Tallquist

2016

Circ J

217

174

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“…Various sources of cells were studied to treat MI. These cells include telocytes, skeletal myoblasts, BMSCs, EPCs, MSCs, ESCs and iPSCs . Intrinsic heart stem cells in MI treatment research have propelled the recent clinical trials using ckit‐positive CSCs or cardiosphere‐derived cells .…”

Section: Discussionmentioning

confidence: 99%

Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction

Wang

Dong

Niu

et al. 2017

J Cellular Molecular Medi

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Over the past decade, cell therapies have provided promising strategies for the treatment of ischaemic cardiomyopathy. Particularly, the beneficial effects of stem cells, including bone marrow stem cells (BMSCs), endothelial progenitor cells (EPCs), mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs), have been demonstrated by substantial preclinical and clinical studies. Nevertheless stem cell therapy is not always safe and effective. Hence, there is an urgent need for alternative sources of cells to promote cardiac regeneration. Human villous trophoblasts (HVTs) play key roles in embryonic implantation and placentation. In this study, we show that HVTs can promote tube formation of human umbilical vein endothelial cells (HUVECs) on Matrigel and enhance the resistance of neonatal rat cardiomyocytes (NRCMs) to oxidative stress in vitro. Delivery of HVTs to ischaemic area of heart preserved cardiac function and reduced fibrosis in a mouse model of acute myocardial infarction (AMI). Histological analysis revealed that transplantation of HVTs promoted angiogenesis in AMI mouse hearts. In addition, our data indicate that HVTs exert their therapeutic benefit through paracrine mechanisms. Meanwhile, injection of HVTs to mouse hearts did not elicit severe immune response. Taken together, our study demonstrates HVT may be used as a source for cell therapy or a tool to study cell‐derived soluble factors for AMI treatment.

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The functional morphology and role of cardiac telocytes in myocardium regeneration

Cited by 20 publications

References 52 publications

Identification of telocytes in the porcine heart

Identification of telocytes in the porcine heart

Defining the Cardiac Fibroblast

Transplantation of human villous trophoblasts preserves cardiac function in mice with acute myocardial infarction

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