The human QARS locus: assignment of the human gene for glutaminyl-tRNA synthetase to chromosome 1q32?42

Abstract

We have used a cDNA encoding the core region of the human glutaminyl-tRNA synthetase to determine the chromosomal localization of the corresponding gene. Southern blots of restricted DNA from a panel of rodent-human cell lines and in situ chromosome hybridization gave identical results showing that the human gene locus for glutaminyl-tRNA synthetase resides on the distal long arm of chromosome 1. There are now nine mapped aminoacyl-tRNA synthetase genes in the human genome.

Report of the committee on the genetic constitution of chromosome 1

“…A locus for a DNAdamage inducible gene (DDIT1) also maps to chromosome 1 (Papathanasiou et al, 1991). The LAP 18 gene for an 18 kD leukemia associated cytosol phosphoprotein was regionalized at Ip36.1-p35 (Ferrari et al, 1990); a locus (HRES1) for an HTLVrelated endogenous sequence assigned to lq42 (Perl et al, 1991); and the QARS locus for glutaminyl-tRNA synthetase located at Iq32-q42 (Kunze et al, 1990).…”