Myositis-associated antigens. Aminoacyl-tRNA synthetases Jo-1, PL-7, PL-12, EJ, and OJ

Plötz, Paul H.; Targoff, Ira N.

doi:10.1007/978-94-011-5444-4_17

Cited by 2 publications

(2 citation statements)

References 37 publications

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“…All patients were treated with prednisone and most required the addition of methotrexate, cyclosporine, or azathioprine. Therapy also included tacrolimus, intravenous immunoglobulin, cyclophosphamide, 4,6,9,11,16, and 18), with normal creatine kinase levels, improved muscle strength, and a minimal corticosteroid requirement. Not all had normal strength and some required multiple immunosuppressive agents to control their myopathy, but normal strength was recovered with only prednisone treatment in 2.…”

Section: Identification Of Autoantibodies and Clinical Featuresmentioning

confidence: 99%

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Anti–signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy

Kao¹,

Lacomis²,

Lucas³

et al. 2004

Arthritis & Rheumatism

256

182

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Objective. To determine the long-term outcome and associated clinical, serologic, and pathologic features in a cohort of patients with connective tissue disease (CTD) and the anti-signal recognition particle (anti-SRP) autoantibody.Methods. Sera and clinical data were collected prospectively from consecutive adult patients with polymyositis (PM; n ‫؍‬ Conclusion. The anti-SRP autoantibody is not specific for PM. Severe muscle weakness and atrophy were prominent features in PM patients with anti-SRP.

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Section: Identification Of Autoantibodies and Clinical Featuresmentioning

confidence: 99%

“…Myositis-specific autoantibodies (MSAs) include those directed against aminoacyl-transfer RNA (aminoacyl-tRNA) synthetases (antisynthetase), signal recognition particle (SRP), and the helicase enzyme (1)(2)(3)(4). MSAs define subgroups of idiopathic inflammatory myopathy (IIM) patients with distinguishing clinical features.…”

mentioning

confidence: 99%

Anti–signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy

Kao¹,

Lacomis²,

Lucas³

et al. 2004

Arthritis & Rheumatism

256

182

View full text Add to dashboard Cite

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Laboratory evaluation of the inflammatory myopathies

Rider

Miller

1995

Clin Diagn Lab Immunol

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The laboratory plays an important role in the diagnosis, evaluation, and classification of the heterogeneous group of diseases known as the IIM, which are characterized by chronic muscle inflammation. Serial measurements of the levels of muscle-derived enzymes in serum are the traditional laboratory studies used to follow the clinical course of patients with IIM, although other laboratory tests can also be useful in assessing myositis disease activity. Several markers of immune system activation, including cytokines and lymphocyte markers, show promise as possibly more sensitive measures of myositis disease activity. Discovery of a unique group of MSAs over the past decade has provided an immunologic basis for defining relatively homogeneous subsets of patients who share similar clinical features, disease courses, and responses to therapy. Future investigations of novel immunologic activation markers, as well as the cloning and expression of target autoantigens of the MSAs, should allow better diagnostic assays, enhanced prognosis, and a better understanding of the pathogenesis of these disorders.

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Myositis-associated antigens. Aminoacyl-tRNA synthetases Jo-1, PL-7, PL-12, EJ, and OJ

Cited by 2 publications

References 37 publications

Anti–signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy

Anti–signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy

Laboratory evaluation of the inflammatory myopathies

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