The human pregnancy-specific β1-glycoprotein (PSβG) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family

Streydio, Catherine; Łącka, Katarzyna; Swillens, Stéphane; Vassart, Gilbert

doi:10.1016/0006-291x(88)90660-2

Cited by 61 publications

(26 citation statements)

References 18 publications

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“…PSG2 is a member of a subgroup of the CEA family that contains several glycoproteins that are highly expressed in human placenta (19,20). CEA, the prototype molecule of the CEA family, is an acidic (pI 3-4) 180-kDa cell-surface glycoprotein with -50o of its molecular mass being carbohydrate and is an important tumor marker of human adenocarcinoma of the colon, lung cancer, and breast cancer (14,25).…”

Section: Resultsmentioning

confidence: 99%

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Williams

Jiang

Holmes

1991

Proc. Natl. Acad. Sci. U.S.A.

381

343

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The BALB/c (6,7). Resistance of SJL/J mice to MHV infection is a recessive trait mapped to the Hv-2 locus on mouse chromosome 7 (8, 9). Membranes from intestine and liver of SJL/J mice do not bind MHV or anti-receptor mAb CC1, suggesting that resistance to infection is due to absence of a functional virus receptor (3, 4). SJL/J mice express a 100-to 110-kDa glycoprotein antigenically related to the MHV receptor. Because this SJL/J receptor homolog binds neither MHV-A59 virus nor anti-receptor mAb CC1, we postulated that it has a mutation affecting the domain of the glycoprotein that normally would bind MHV and mAb CC1 (4). In this communication we demonstrate that the MHV receptor glycoprotein of BALB/c and Swiss Webster mice and its SJL/J homolog are members of the carcinoembryonic antigen (CEA) family of glycoproteins in the immunoglobulin superfamily.

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Section: Resultsmentioning

confidence: 99%

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Williams

Jiang

Holmes

1991

Proc. Natl. Acad. Sci. U.S.A.

381

343

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“…This PS/G species contains the Arg-Gly-Asp tripeptide (amino acids 126-128) in a position similar to that found in some other PSPG species (13,14,17,19,22). This tripeptide is also present in the well known cellular adhesion molecule N-CAM and in other proteins that are known to be important in the cellular recognition process (27,33).…”

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confidence: 89%

“…27), within the immunoglobulin superfamily contain the surface active tripeptide Arg-GlyAsp, which acts in cell-surface recognition. Many members of the PSI3G gene family (including PSGGB in this study) are closely related to N-CAM and encode proteins that contain the Arg-Gly-Asp tripeptide (13,14,17,19,22). In this paper, we explore the possibility that the PSGGB-encoded protein may be involved in the genesis of gestational trophoblastic disease by acting as an adhesion molecule.…”

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confidence: 99%

“…We found that placental PS/3G represents a family of closely related glycoproteins of 72, 64, and 54 kDa and that placental poly(A)+ RNA directed the synthesis of three polypeptides of 50, 48 (major), and 36 kDa as immunoprecipitated by anti-PS3G serum (11). Moreover, near-full-length cDNAs encoding members ofthe PSf3G family were isolated and characterized by our laboratory (11,12) as well as by others (13)(14)(15)(16)(17)(18)(19)(20). Two gene fragments that share strong sequence similarity with the reported PSfG cDNAs have been reported (21,22).…”

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confidence: 99%

“…2), and utilizes a polyadenylylation site beginning at PSGGA nt 902. PSGC (13) and PSG95 differ by the presence of an additional 355-bp sequence (nt 1405-1759) in PSG95 (Fig. 1).…”

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confidence: 99%

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Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

Leslie

Watanabe

Lei

et al. 1990

Proc. Natl. Acad. Sci. U.S.A.

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A genomic clone containing two linked human pregnancy-specific (31-glycoprotein (PSI3G) genes has been isolated and characterized. The two genes are arranged in the same 5' -+ 3' orientation; the 3' region (including the A2and B-C exons) of the upstream gene, PSGGA, is linked to the 5' region (including the 5'/L and L/N exons) of PSGGB, the downstream gene. Depending upon the domains compared, PSGGA and PSGGB share 92-98% nucleotide and 86-95%

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Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

Thompson

Fritz

Zimmermann

1991

Clinical Laboratory Analysis

557

389

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The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons. In humans it is clustered on the long arm of chromosome 19 and consists of approximately 20 genes. The CEA subgroup genes code for CEA and its classical crossreacting antigens, which are mainly membrane-bound, whereas the other subgroup genes encode the pregnancy-specific glycoproteins (PSG), which are secreted. Splice variants of individual genes and differential post-translational modifications of the resulting proteins, e.g., by glycosylation, indicate a high complexity in the number of putative CEA-related molecules. So far, only a limited number of CEArelated antigens in humans have been unequivocally assigned to a specific gene.Rodent CEA-related genes reveal a high sequence divergence and, in part, a completely different domain organization than the human CEA gene family, making it difficult to determine individual gene counterparts. However, rodent CEA-related genes can be assigned to human subgroups based on similarity of expression patterns, which is characteristic for the subgroups. Various functions have been determined for members of the CEA subgroup in vitro, including cell adhesion, bacterial binding, an accessory role for collagen binding or ecto-ATPases activity.Based on all that is known so far on its biology, the clinical outlook for the CEA family has been reassessed.

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The human pregnancy-specific β1-glycoprotein (PSβG) and the carcinoembryonic antigen (CEA)-related proteins are members of the same multigene family

Cited by 61 publications

References 18 publications

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.

Carcinoembryonic antigen gene family: Molecular biology and clinical perspectives

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