Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Williams, Russell B.; Jiang, Guojian; Holmes, Kathryn V.

doi:10.1073/pnas.88.13.5533

Cited by 381 publications

(350 citation statements)

References 39 publications

Supporting

Mentioning

343

Contrasting

Order By: Relevance

“…A l l0K receptor protein has been isolated from the brush border membrane of hepatocytes and enterocytes (Williams et al, 1990) and was shown to belong to the carcinoembryonic antigen family of glycoproteins (Williams et al, 1991). In the case of MHV it is not known whether Neu5,9Ac2 is involved in virus binding or infection of cells.…”

Section: Discussionmentioning

confidence: 99%

“…Strain MHV-A59 has been shown to bind to a 100K to 110K protein present in membranes from hepatocytes and enterocytes of susceptible mice, but absent in comparable preparations from resistant mice (Boyle et al, 1987). A monoclonal anti-receptor antibody that prevents MHV from infecting susceptible mouse cells was used for affinity purification of the receptor (Williams et al, 1990), which has been shown to be a member of the carcinoembryonic antigen family of glycoproteins (Williams et al, 1991). It is not known whether a related receptor is required for other coronaviruses to initiate infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells

Schultze

Herrler

1992

Journal of General Virology

View full text Add to dashboard Cite

The importance of N-acetyl-9-O-acetylneuraminic acid (Neu5,9Ac2) as a receptor determinant for bovine coronavirus (BCV) on cultured cells was analysed. Pretreatment of MDCK I (Madin Darby canine kidney) cells with neuraminidase or acetylesterase rendered the cells resistant to infection by BCV. The receptors on a human (CaCo-2) and a porcine (LLC-PK1) epithelial cell line were also found to be sensitive to neuraminidase treatment. The susceptibility to infection by BCV was restored after resialylation of asialo-MDCK i cells with Neu5,9Ac2. Transfer of sialic acid lacking a 9-O-acetyl group was ineffective in this respect. These results demonstrate that 9-0-acetylated sialic acid is used as a receptor determinant by BCV to infect cultured cells. The possibility is discussed that the initiation ofa BCV infection involves the recognition of different types of receptors, a first receptor for primary attachment and a second receptor to mediate the fusion between the viral envelope and the cellular membrane.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells

Schultze

Herrler

1992

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…Although speculative, the function of VCBPs might be to recognize determinants on various pathogens. There is considerable precedent for IgSF-related viral receptors, including those for poliovirus (poliovirus receptor) 116 , reovirus (junctional adhesion molecule, JAM) 117 , HIV (CD4) 118 , mouse hepatitis virus (CEA-related cell-adhesion molecule 1, CEACAM1) 119 , measles virus (signalling lymphocytic activation molecule, SLAM) 120 and others. Other potential functions for VCBPs include binding to fungal or bacterial surfaces, direct opsonization, and self-and non-self-recognition 3,7 .…”

Section: Vcbps In Protochordatesmentioning

confidence: 99%

Reconstructing immune phylogeny: new perspectives

2005

View full text Add to dashboard Cite

Numerous studies of the mammalian immune system have begun to uncover profound interrelationships, as well as fundamental differences, between the adaptive and innate systems of immune recognition. Coincident with these investigations, the increasing experimental accessibility of non-mammalian jawed vertebrates, jawless vertebrates, protochordates and invertebrates has provided intriguing new information regarding the likely patterns of emergence of immune-related molecules during metazoan phylogeny, as well as the evolution of alternative mechanisms for receptor diversification. Such findings blur traditional distinctions between adaptive and innate immunity and emphasize that, throughout evolution, the immune system has used a remarkably extensive variety of solutions to meet fundamentally similar requirements for host protection.The evolutionary development of the METAZOANS was associated with the diversification of a wide range of specialized cell-surface molecules that mediate key metabolic processes, as well as provide crucial contact interfaces and carry out a broad range of other essential functions. It is not unexpected that some of these molecules also came to function as barriers to pathogenic invasion and, in doing so, began to carry out dedicated innate immune protective functions. Whereas the simplest form of protection, barrier formation, is essentially mechanical in nature, relentless pressure from genetic variation in pathogens probably drove the evolution of such innate immune protective molecules towards diversification and, in parallel, towards integration of signalling pathways to regulate cellular responses to external stimulation. However, despite the sophistication that such innate immune mediators achieved over time, their biological complexity, by definition, would be limited by genome space, so with increasing complexity of body plan and/or increasing pathogen sophistication, they could be overwhelmed. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptMore than 500 million years ago, a TRANSPOSITION event, probably involving a recombinationactivating gene (RAG)-bearing element, might have given rise to the predecessors of the rearranging antigen-binding receptors of the jawed vertebrates, which encompass the vertebrate radiations that extend from the cartilaginous fish through to humans. This is considered the defining point in the emergence of RAG-mediated (conventional) adaptive immunity 1,2 , which has evolved to create a mechanism for deriving almost limitless variation from very few genes. Studies in traditional and non-traditional animal models, such as sharks, bony fish and birds, have brought this event and its ramifications for host defence into sharper focus. We can now predict much about how these rearranging antigenbinding receptors probably arose, what alternative pathways of immune-receptor gene evolution have occurred, what relationships exist between B-and T-cell-mediated immunity and natural killer (NK)-cell function, how complex immune ...

show abstract

“…Kim et al, 1991;H. Wang et al, 1991Williams et al, 1991Brown et al, 1993Hofer et al, 1994 envelope with the limiting cellular membrane (Fig. 1).…”

mentioning

confidence: 99%

Viral cell recognition and entry

Rossmann

1994

Protein Science

143

View full text Add to dashboard Cite

Rhinovirus infection is initiated by the recognition of a specific cell-surface receptor. The major group of rhinovirus serotypes attach to intercellular adhesion molecule-1 (ICAM-1). The attachment process initiates a series of conformational changes resulting in the loss of genomic RNA from the virion. X-ray crystallography and sequence comparisons suggested that a deep crevice or canyon is the site on the virus recognized by the cellular receptor molecule. This has now been verified by electron microscopy of human rhinovirus 14 (HRV14) and HRV16 complexed with a soluble component of ICAM-1.A hydrophobic pocket underneath the canyon is the site of binding of various hydrophobic drug compounds that can inhibit attachment and uncoating. This pocket is also associated with an unidentified, possibly cellular in origin, "pocket factor." The pocket factor binding site overlaps the binding site of the receptor. It is suggested that competition between the pocket factor and receptor regulates the conformational changes required for the initiation of the entry of the genomic RNA into the cell.

show abstract

Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.

Cited by 381 publications

References 39 publications

Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells

Bovine coronavirus uses N-acetyl-9-O-acetylneuraminic acid as a receptor determinant to initiate the infection of cultured cells

Reconstructing immune phylogeny: new perspectives

Viral cell recognition and entry

Contact Info

Product

Resources

About