The Human Physiome: a necessary key for the creative destruction of medicine

Omholt, Stig W; Hunter, Peter

doi:10.1098/rsfs.2016.0003

Cited by 9 publications

(8 citation statements)

References 17 publications

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“…Physiome is a multiscale approach aiming at functionally synthesizing models at different levels, and at understanding human physiology based on computational models. 341 Standardization of models has been part of this effort, and an important number of models is now available in the physiome repository ( ).…”

Section: Network Analysis Softwarementioning

confidence: 99%

An Early Stage Researcher's Primer on Systems Medicine Terminology

Zanin

Aitya

Basílio

et al. 2021

Network and Systems Medicine

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Background: Systems Medicine is a novel approach to medicine, that is, an interdisciplinary field that considers the human body as a system, composed of multiple parts and of complex relationships at multiple levels, and further integrated into an environment. Exploring Systems Medicine implies understanding and combining concepts coming from diametral different fields, including medicine, biology, statistics, modeling and simulation, and data science. Such heterogeneity leads to semantic issues, which may slow down implementation and fruitful interaction between these highly diverse fields. Methods: In this review, we collect and explain more than100 terms related to Systems Medicine. These include both modeling and data science terms and basic systems medicine terms, along with some synthetic definitions, examples of applications, and lists of relevant references. Results: This glossary aims at being a first aid kit for the Systems Medicine researcher facing an unfamiliar term, where he/she can get a first understanding of them, and, more importantly, examples and references for digging into the topic.

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Section: Network Analysis Softwarementioning

confidence: 99%

An Early Stage Researcher's Primer on Systems Medicine Terminology

Zanin

Aitya

Basílio

et al. 2021

Network and Systems Medicine

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show abstract

“…Hunter, Li, McCulloch, & Noble, 2006;P. Hunter, Robbins, & Noble, 2002;Omholt & Hunter, 2016). Physiome makes efforts to apply the formalized approach in order to integrate our knowledge, from the cell level to the organ level to the whole-body level, with a view to gaining insight into how all that works as a whole.…”

Section: Formalization Of Physiological Relations -The Physiome Projectmentioning

confidence: 99%

Modelica language - a promising tool for publishing and sharing biomedical models

Kofránek

Ježek

Matejak

2019

Linköping Electronic Conference Proceedings

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Current biomedical models are so extensive that their description (and reproducibility) requires more than a set of equations. Journal papers are thus frequently accompanied by electronic enclosures with detailed model descriptions, or even better, with a complete model source code. Specific electronic archives associated with specific languages and publicly accessible simulation platforms for the creation and archiving of biomedical models have been set up, however each of them has some disadvantage and an agreement on a common language for model sharing is missing. This paper reviews the usage of the languages for physiological modeling and discusses the advantages of the Modelica language in the area of physiological simulations.

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“…Hunter et al 2006;Peter J. Hunter, Crampin, and Nielsen 2008;Omholt and Hunter 2016). "VIRTUAL PHYSIOLOGICAL HUMAN" (http://www.vph-institute.org) is a European initiative in this field, focused, among other things, on applications of the formalized approach to human physiology in clinical medicine (P. Hunter 2016).…”

Section: Integrative Physiologymentioning

confidence: 99%

Integrative physiology in Modelica

Kofránek¹,

Kulhánek²,

Matejak³

et al. 2017

Linköping Electronic Conference Proceedings

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The integrative model of human physiology connects individual physiological subsystems into a single unit. They are enormous (contain thousands of variables) and represent a formalized description of interconnected physiological regulations. The issue of formalization of physiological systems became part of a series of international projects (e.g. the worldwide program "PHYSIOME", or the European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiology was facilitated by a new generation (i.e. equation-based) of simulation environments, especially by the Modelica language. These models can be used to explain the causal relations of the pathogenesis of many diseases. They can be applied in the evaluation of clinical trials and they can also be used in the core of sophisticated medical simulators.

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The Human Physiome: a necessary key for the creative destruction of medicine

Abstract: One contribution of 12 to a theme issue 'The Human Physiome: a necessary key to the creative destruction of medicine'.

Cited by 9 publications

References 17 publications

An Early Stage Researcher's Primer on Systems Medicine Terminology

An Early Stage Researcher's Primer on Systems Medicine Terminology

Modelica language - a promising tool for publishing and sharing biomedical models

Integrative physiology in Modelica

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