The human ovarian follicular fluid level of interleukin-8 is associated with follicular size and patient age

Serum but not follicular fluid cytokine levels are increased in stimulated versus natural cycle IVF: a multiplexed assay study

“…In contrast to IL-6, FF IL-8 concentrations were found to be significantly lower in older women (Malizia et al, 2010). The role of follicular IL-6, IL-8 and other cyto-/chemokines in peri-ovulatory and inflammatory processes was further illustrated five years later (Büscher et al, 1999).…”

Effect of time between human chorionic gonadotropin injection and egg retrieval is age dependent

“…It has been recently demonstrated that reproductive aging is associated with altered gene expression in human luteinized granulosa cells; as evidenced by measurement of messenger RNA from mural granulosa cells, interleukin (IL)-1 and IL-6, both implicated in folliculogenesis and ovulation, are downregulated with advancing age (16). Consistent with these findings, levels of IL-8 have been shown to be diminished in the follicular fluid of older women as compared with younger controls (17). Although it is certainly biologically plausible that the intricate events underlying meiotic resumption and chromosome segregation during meiotic maturation may slow with age, no study to date has investigated this possibility.…”

Intrafollicular inflammatory cytokines but not steroid hormone concentrations are increased in naturally matured follicles of women with proven endometriosis

“…These factors also seem to play a role in reproduction as previous studies [28,29] noted a correlation of IL-8 with follicular size and therefore suggested IL-8 as an intrafollicular marker of follicular maturity. Follicular fluid IL-18 at the time of oocyte retrieval was positively correlated with the number of oocytes and the chance for successful pregnancy [30,31].…”