Effect of time between human chorionic gonadotropin injection and egg retrieval is age dependent

Reichman, Daniël; Missmer, Stacey A.; Berry, Katharine; Ginsburg, Elizabeth S.; Racowsky, Catherine

doi:10.1016/j.fertnstert.2011.02.043

Cited by 10 publications

(6 citation statements)

References 17 publications

(21 reference statements)

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“…Of interest, a recent study by Reichman et al found that extending exposure to HCG for oocytes maturation may be beneficial to patients aged over 40 in IVF treatment. They considered reproductive aging might be associated with altered gene expression in luteinized granulosa cells [28]. We also consider our results might be related to reproductive aging.…”

Section: Discussionmentioning

confidence: 68%

Different ovarian response by age in an anti-Müllerian hormone-matched group undergoing in vitro fertilization

Honnma¹,

Baba

Sasaki³

et al. 2011

J Assist Reprod Genet

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Section: Discussionmentioning

confidence: 68%

Different ovarian response by age in an anti-Müllerian hormone-matched group undergoing in vitro fertilization

Honnma¹,

Baba

Sasaki³

et al. 2011

J Assist Reprod Genet

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“…In 2011, Reichman et al found no consistent difference in oocyte yield, maturity, fertilization, or embryo quality between cycles with a prolonged interval of > 36.5 hours, as compared to those with a shorter interval. However, in older women trends toward improved implantation, clinical pregnancy, and live birth were observed with the prolonged interval [16].…”

Section: Introductionmentioning

confidence: 95%

“…However, the fertilization, implantation, and pregnancy rates did not differ significantly with prolonged intervals. Views are mixed regarding a possible impact of an association of age with a shorter or longer hCG-OPU interval on IVF outcomes [15,16]. A retrospective analysis showed much higher oocyte immaturity in IVF cycles for women aged 41 years or more [15].…”

Section: Introductionmentioning

confidence: 99%

“…The trend to delay parenthood is enhancing around the world and the proportion of live births to older mothers 35-49 years has increased dramatically in recent years [17]. Older women undergoing IVF have lower success rates [15][16][17], and the present research explored a new approach to this elder population. The aim of this retrospective cohort study was to investigate associations of longer and shorter hCG-OPU time intervals with oocyte maturation, embryo morphology, morphokinetics, and IVF outcome, with a focus on patients' age.…”

Section: Introductionmentioning

confidence: 99%

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Time interval between hCG administration and oocyte pick up: analysis of oocyte maturation, embryonic morphology, morphokinetics, and IVF outcome

Skvirsky¹,

Blais²,

Lahav-Baratz³

et al. 2021

Clinical and Experimental Obstetrics & Gynecology

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To investigate associations of the time interval between hCG administration and oocyte pick up with oocyte maturation, embryonic morphology, morphokinetics, and IVF outcome, in di ferent age groups. Design: A retrospective cohort study. Setting: An academic medical center. Patients: Women who underwent IVF and ICSI cycles in which all oocytes were incubated in a time lapse microscopy system (EmbryoScope). Cycles were stratified by age and time from hCG exposure. Interventions: None. Main Outcome Measures: Of 2185 IVF/ICSI OPU cycles, 820 cycles were included in the analysis. Final analysis was made on 796 cycles (4930 oocytes). Oocyte number and their maturity, fertilization rates, and embryo quality defined by morphology and morphokinetics, clinical pregnancy, and live birth rates. Results: The median hCG-oocyte pick up (OPU) interval was 34.45 hours. Among women over age 36 years, longer intervals were associated with both a higher fraction of mature oocytes (P < 0.008) and better morphology grading of embryos (P < 0.01). At all ages and all intervals, those with cleavage time, t2 ≤ 27 hours achieved a statistically significant higher clinical pregnancy rate. No di ferences were found in morphokinetics (t2) between di ferent hCG-OPU intervals for any of the age groups. Conclusions: Extending hCG to OPU interval may be beneficial for patients aged > 36 years, as more mature eggs and better embryo morphology were achieved. In older women with fewer oocytes retrieved, even a small extra number of mature oocytes may prove crucial for treatment outcome and improve success rates. A prospective, randomized study is warranted to determine whether optimal hGC-retrieval time interval merits revision/adjustment for older women.

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“…Controlled ovarian hyperstimulation using either GnRH agonist down-regulation, co-flare, or GnRH antagonists to suppress ovulation were employed as per our routine protocols [9]. When >4 follicles were observed, with two lead follicles measuring >18 mm in diameter, 10,000 IU of intramuscular hCG (Profasi: Serono, Geneva, Switzerland or Novarel: Ferring Pharmaceuticals Inc., Suffern, NY) was administered.…”

Section: Clinical Protocolsmentioning

confidence: 99%

Day 3 embryo shape as a morphologic selection parameter in in vitro fertilization

Kamran

Reichman

Missmer

et al. 2012

J Assist Reprod Genet

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Purpose To investigate whether embryo shape is a useful morphologic predictor of developmental competence in IVF cycles. Methods Two hundred eighteen day 3 single embryo transfer (SET) cycles and 225 day 3 double embryo transfer (DET) cycles in which only 8-cell non-fragmented embryos with symmetric blastomeres were transferred and in which the developmental fate of each embryo was known were analyzed for IVF outcomes with respect to embryo shape. Embryo shape was quantitatively calculated after digitizing embryo images using MATLAB, where a score of 1.0 represented a perfectly circular embryo. Results The SET data did not reveal a significant impact of embryo shape on embryo developmental fate. The DET data revealed a trend toward the best outcomes in cycles where both embryos exhibited "roundness" scores in the highest tertiles (T3) for embryo shape. However only one subgroup (T2/T1-one embryo in the middle shape tertile (T2) and one in the lowest shape tertile (T1)) was associated with significantly lower odds of live-birth as compared to the referent group (T3/T3). When SET and DET data were combined, embryo shape was not found to be a predictor of IVF outcome. Conclusions Based on this retrospective analysis, the weak association of day 3 embryo shape with implantation potential suggests that this morphological characteristic is unlikely to be a useful additional marker for embryo selection after cell number, fragmentation, and blastomere symmetry. Further studies are planned to assess applicability of these conclusions to embryos of varying stages and grades.

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Effect of time between human chorionic gonadotropin injection and egg retrieval is age dependent

Cited by 10 publications

References 17 publications

Different ovarian response by age in an anti-Müllerian hormone-matched group undergoing in vitro fertilization

Different ovarian response by age in an anti-Müllerian hormone-matched group undergoing in vitro fertilization

Time interval between hCG administration and oocyte pick up: analysis of oocyte maturation, embryonic morphology, morphokinetics, and IVF outcome

Day 3 embryo shape as a morphologic selection parameter in in vitro fertilization

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