The Human Microbiota and Skin Cancer

Woo, Yu Ri; Cho, Sang Hyun; Lee, Jeong Deuk; Kim, Hei Sung

doi:10.3390/ijms23031813

Cited by 50 publications

(49 citation statements)

References 148 publications

(232 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Advances in microbial research have illuminated understanding of immune and inflammatory pathways in the tumor microenvironment, as well as pathogenesis and cancer progression (25). Given that chronic inflammation is known to create a pro-cancer environment and microbial dysbiosis is associated with mechanisms of inflammation, the abundance of certain microbes is linked to the development of specific cancer types, including skin cancer.…”

Section: Skin Microbiome In Cancermentioning

confidence: 99%

“…Healthy skin is primarily characterized with Firmicutes, in which Staphylococcus, Streptococcus, and Lactobacillus are dominant (26). Although the mechanism of bacteria-inducing tumor proliferation is not well understood, there are several contributing processes, such as the production of toxins and inflammation, which leads to DNA damage and induce a proinflammatory environment in the skin (25,(29)(30)(31)(32).…”

Section: Skin Microbiome In Cancermentioning

confidence: 99%

See 1 more Smart Citation

Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer: A Mini-Review

et al. 2022

View full text Add to dashboard Cite

The human skin hosts millions of bacteria, fungi, archaea, and viruses. These skin microbes play a crucial role in human immunological and physiological functions, as well as the development of skin diseases, including cancer when the balance between skin commensals and pathogens is interrupted. Due to the linkages between inflammation processes and skin microbes, and viral links to skin cancer, new theories have supported the role a dysbiotic skin microbiome plays in the development of cancer and cancer treatment-related skin toxicities. This review focuses on the skin microbiome and its role in cancer treatment-related skin toxicities, particularly from chemotherapy, radiation therapy, and immunotherapy. The current literature found changes in the diversity and abundance of the skin microbiome during cancer treatments such as radiation therapy, including lower diversity of the skin microbiome, an increased Proteobacteria/Firmicutes ratio, and a higher abundance of pathogenic Staphylococcus aureus. These changes may be associated with the development and severity of treatment-related skin toxicities, such as acute radiation dermatitis, hand-foot syndrome in chemotherapy, and immunotherapy-induced rash. Several clinical guidelines have issued potential interventions (e.g., use of topical corticosteroids, phototherapy, and non-pharmaceutical skin care products) to prevent and treat skin toxicities. The effectiveness of these promising interventions in alleviating treatment-related skin toxicities should be further tested among cancer patients.

show abstract

Section: Skin Microbiome In Cancermentioning

confidence: 99%

Section: Skin Microbiome In Cancermentioning

confidence: 99%

Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer: A Mini-Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Probiotics can increase macrophage and NK cell mobilization (10), as well as promote IgG and IgA production (11), and stimulate apoptosis and inhibit tumor cell growth through phagocytosis (12). Skin cancers, such as non-melanoma skin cancer (NMSC) and melanoma, are linked to microbiota imbalance (13). Some studies, for example, have found a link between Staphylococcus aureus and squamous cell carcinoma (14).…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

“…The use of probiotics and microbiota in the treatment of skin cancer is becoming more popular (13). Several studies have shown that Staphylococcus epidermidis has antiproliferative properties against SCC and melanoma (21,22).…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Microbiota, probiotics and common skin cancer: Association and therapeutic application

Javaherian

Bakhtiari²,

Ajoudanifar³

et al. 2022

J Biol Res

View full text Add to dashboard Cite

Numerous commensal microorganisms live on human skin and play an important role in human health. Any type of abnormality in the skin microbiome can result in skin damage and various diseases. Skin disorders such as atopic dermatitis and psoriasis are common skin complications caused by an imbalance of skin microorganisms. Probiotics are live microorganisms that, when consumed in sufficient quantities, can benefit human health. Using probiotics to treat various skin complications has gained popularity in recent years. Probiotics have proven to be a promising agent for improving skin health and condition, with the potential to reduce skin pathogens and boost skin immunity through antimicrobial agent production and nutrient competition. The rising incidence of skin cancer, particularly melanoma, over the last four decades emphasizes this point. The link between skin microbiota imbalance and skin cancer, particularly Non-Melanoma Skin Cancer (NMSC) and melanoma, is becoming clearer. As a result, based on the proven ability of probiotics to improve skin health. The use of microorganisms such as probiotics as a supplement in conjunction with immunotherapy has gained popularity. The purpose of this review is to discuss the relationship between microbiota imbalance and skin cancer, as well as the use of probiotics in cancer treatment.

show abstract

“…Many in ammatory response-related characteristics in the peripheral blood of patients with SKCM, such as thrombocytosis, leukocytosis, hypoproteinemia, and increased plasma brin, have been established in investigations [15] [16]. In the overall survival analysis of cancer, clinical systemic in ammatory markers such as neutrophil ratio, platelet-lymphocyte ratio, and lymphocyte-monocyte ratio revealed substantial predictive potential independent of previously identi ed prognostic variables for SKCM [17].…”

Section: Introductionmentioning

confidence: 99%

A novel inflammatory response-related signature predicts the prognosis of skin cutaneous melanoma and the effect of anti-tumor drugs

Xing

Han

et al. 2022

Preprint

View full text Add to dashboard Cite

Skin cutaneous melanoma (SKCM) is a skin cancer that is highly metastatic and aggressive, with a dismal prognosis. This is the first study to use inflammatory response-related genes to build a model and evaluate their predictive significance in SKCM. This study used public databases to download SKCM patients’ mRNA expression profiles and clinical data to create multigene prognostic markers in the UCSC cohort. We compared overall survival (OS) between high- and low-risk groups using the Kaplan-Meier curve and determined independent predictors using Cox analysis. We also used enrichment analysis to assess immune cell infiltration fraction and immune pathway-related activity using KEGG enrichment analysis. Finally, we detected prognostic genes’ mRNA and protein expression in SKCM and normal skin tissues using qRT-PCR and IHC (data from Human Protein Atlas). Finally, we developed a 5-gene predictive model that showed that patients in the high-risk group had a considerably shorter OS than those in the low-risk group. The analysis of the receiver operating characteristic (ROC) curve proved the model’s predictive ability. Furthermore, we conducted a drug sensitivity analysis and discovered that the expression levels of prognostic genes were substantially linked with cancer cell sensitivity to antitumor medicines. The findings show that the model we developed, which consists of five inflammatory response-related genes, can be used to forecast the prognosis and immunological state of cutaneous melanoma, giving personalized medicine and precision medicine a new goal and direction.

show abstract

The Human Microbiota and Skin Cancer

Cited by 50 publications

References 148 publications

Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer: A Mini-Review

Skin Microbiome and Treatment-Related Skin Toxicities in Patients With Cancer: A Mini-Review

Microbiota, probiotics and common skin cancer: Association and therapeutic application

A novel inflammatory response-related signature predicts the prognosis of skin cutaneous melanoma and the effect of anti-tumor drugs

Contact Info

Product

Resources

About