The Human Hepatocyte Nuclear Factor 3/Fork Head Gene FKHL13: Genomic Structure and Pattern of Expression

Murphy, Derek; Seemann, Stefanie; Wiese, Stefan; Kirschner, Renate; Grzeschik, K.-H.; Thies, Ulrike

doi:10.1006/geno.1996.4587

Cited by 36 publications

(34 citation statements)

References 26 publications

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“…Two alternative exons, present in isoform HFH-11A (Ye et aL, 1997), were designated exon Va and exon Vila. Interestingly, intron 4 is present in the region encoding the winged-helix do main at the same position as was reported for an other member of this family, FKHL13 (Murphy et aL, 1997).…”

Section: Fig 4 (A)supporting

confidence: 68%

The HumanTRIDENT/HFH-11/FKHL16Gene: Structure, Localization, and Promoter Characterization

Korver¹,

Roose²,

Heinen³

et al. 1997

Genomics

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We recently identified the w inged-helix/fork head transcription factor Trident in mouse and described its expression in cycling cells. Here w e report the iso lation and characterization of the hum an TRIDENT (HGMW-approved sym bol FKHL16) cDNA and gene. Homology betw een th e hum an and th e m ouse Trident proteins was 79%. The gene consists o f 10 exons and is located on chrom osom e 12 band p l3 . The wingedhelix DNA-binding dom ain is encoded on three exons. Analysis of the prom oter in synchronized Rat-1 fibro blasts revealed a fragm ent of 300 b ases responsible for the cell cycle-specific expression o f th e TRIDENT gene. < D 1997 Academic P ress

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Section: Fig 4 (A)supporting

confidence: 68%

The HumanTRIDENT/HFH-11/FKHL16Gene: Structure, Localization, and Promoter Characterization

Korver¹,

Roose²,

Heinen³

et al. 1997

Genomics

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“…This gene is a member of the forkhead/winged-helix family of transcription factors that are expressed in tissue-specific patterns and play critical roles in development and cell differentiation. 46 This gene has not been implicated in the development of any type of tumor previously, and its role in cancer needs to be further explored.…”

Section: Discussionmentioning

confidence: 99%

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis

Missiaglia

Blaveri

Terris

et al. 2004

Intl Journal of Cancer

139

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Pancreatic cancer is a highly aggressive type of malignancy and the prognosis for disease presenting typically at a late stage is extremely poor. A comprehensive understanding of its molecular genetics is required in order to develop new approaches to clinical management. To date, serial analysis of gene expression and more recently oligo/cDNA microarray technologies have been employed in order to identify genes involved in pancreatic neoplasia that can be developed as diagnostic markers and drug targets for this dismal disease. This study describes the expression profile obtained from 20 pancreatic cell lines using cDNA microarrays containing 9,932 human gene elements. Numerous genes were identified as being differentially expressed, some of which have been previously implicated in pancreatic adenocarcinoma (S100P, S100A4, prostate stem cell antigen, lipocalin 2, claudins 3 and 4, trefoil factors 1 and 2) as well as several novel genes. The differentially expressed genes identified are involved in a variety of cellular functions, including control of transcription, regulation of the cell cycle, proteolysis, cell adhesion and signaling. Validation of our array results was performed by exploring the SAGEmap database and by immunohistochemistry for a selection of 4 genes that have not previously been studied in pancreatic cancer: anterior gradient 2 homologue (Xenopus laevis), insulin-like growth factor binding protein 3 and 4 and Forkhead box J1. Immunostaining was performed using pancreas-specific tissue microarrays containing core biopsies from 305 clinical specimens. In addition, using statistical group comparison and hierarchical clustering, a selection of genes was identified that may be linked to the site of metastasis from which these cell lines were isolated.

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“…In addition, DNA sequence footprints of the X-box promoter motif, the binding site for RFX factors, are found exclusively in ciliary genes within the animal kingdom in co-existence with RFX factors. Therefore, the tight transcriptional control of ciliary genes and cilia formation was most likely 'taken over' by RFX factors early in the animal lineage (Chu et al, 2010;Piasecki et al, 2010 revealed that expression of the gene is spatially restricted to a number of mammalian tissues that differentiate motile cilia, including the choroid plexus, lung epithelium, oviduct and testis (Clevidence et al, 1994;Hackett et al, 1995;Murphy et al, 1997). Based on this expression pattern, Murphy and colleagues presciently suggested that FOXJ1 might play a role in ciliogenesis (Murphy et al, 1997).…”

Section: Reviewmentioning

confidence: 99%

Switching on cilia: transcriptional networks regulating ciliogenesis

et al. 2014

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Cilia play many essential roles in fluid transport and cellular locomotion, and as sensory hubs for a variety of signal transduction pathways. Despite having a conserved basic morphology, cilia vary extensively in their shapes and sizes, ultrastructural details, numbers per cell, motility patterns and sensory capabilities. Emerging evidence indicates that this diversity, which is intimately linked to the different functions that cilia perform, is in large part programmed at the transcriptional level. Here, we review our understanding of the transcriptional control of ciliary biogenesis, highlighting the activities of FOXJ1 and the RFX family of transcriptional regulators. In addition, we examine how a number of signaling pathways, and lineage and cell fate determinants can induce and modulate ciliogenic programs to bring about the differentiation of distinct cilia types.

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The Human Hepatocyte Nuclear Factor 3/Fork Head Gene FKHL13: Genomic Structure and Pattern of Expression

Cited by 36 publications

References 26 publications

The HumanTRIDENT/HFH-11/FKHL16Gene: Structure, Localization, and Promoter Characterization

The HumanTRIDENT/HFH-11/FKHL16Gene: Structure, Localization, and Promoter Characterization

Analysis of gene expression in cancer cell lines identifies candidate markers for pancreatic tumorigenesis and metastasis

Switching on cilia: transcriptional networks regulating ciliogenesis

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