The Human Genome: Chromosomes

Identification of Genetic Diversity of P21-Activated Kinases (PAK1) Gene in Senduro Goats and Boerawa Goats using PCR-RFLP (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism)

“…From Table 3 can be seen the results of chi-square (X2), observation heterozygosity value (Ho), expectation heterozygosity value (He), and Polymorphic Informative Content (PIC) value shows that the genotype frequency of the PAK1 gene fragment exon 9 whose value is constant is 0. The genetic diversity of the PAK1 gene is monomorphic with only one genotype found, namely GG The frequency of genotypes and alleles in HWE will always be constant from generation to generation unless there are selection events, mutations, genetic drift (Noor, 2010), non-random mating, limited population size, and gene flow (Vogel and Motulsky, 1997). The provisions of Hardy-Weinberg's law are that in a population, allele frequency and genotype frequency will remain constant (in equilibrium) from generation to generation, The conditions of the validity of Hardy-Weinberg's law are that the number of individuals or chromosomes of a population is always large (Prime, 2015) and eliminates the selection and mutation process in genetic algorithms (Panggabean, 2016), then the population is in equilibrium (Allendorf et al, 2013).…”