X-autosome translocation and low fertility in a family of crossbred cattle

Basrur, Parvathi K.; Reyes, E R; Farazmand, Ali; King, W.A.; Popescu, P.

doi:10.1016/s0378-4320(01)00089-6

Cited by 19 publications

(11 citation statements)

References 30 publications

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“…These fragile sites may be involved in chromosome rearrangements such as inversions or transpositions; these rearrangements have been described for the chromosomal evolution of BTAX [14]. Moreover, an X-autosomal translocation, involving BTA1 and BTA23, has also been described in cattle and is associated with fertility problems [1,8].…”

Section: Discussionmentioning

confidence: 99%

Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding

Rodríguez¹,

Llambí²,

Postiglioni³

et al. 2002

Genet. Sel. Evol.

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-Fragile sites (FS) seem to play a role in genome instability and may be involved in karyotype evolution and chromosome aberrations. The majority of common fragile sites are induced by aphidicolin. Aphidicolin was used at two different concentrations (0.15 and 0.30 µM) to study the occurrence of FS in the cattle karyotype. In this paper, a map of aphidicolin induced break points and fragile sites in cattle chromosomes was constructed. The statistical analysis indicated that any band with three or more breaks was significantly damaged (P < 0.05). According to this result, 30 of the 72 different break points observed were scored as fragile sites. The Pearson correlation test showed a positive association between chromosome length and the number of fragile sites (r = 0.54). On the contrary, 21 FS were identified on negative R bands while 9 FS were located on positive R bands.cattle / chromosome / fragile sites / aphidicolin

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Section: Discussionmentioning

confidence: 99%

Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding

Rodríguez¹,

Llambí²,

Postiglioni³

et al. 2002

Genet. Sel. Evol.

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“…Virtually all disturbances also found in humans have been described (gonosomal aberrations, X-or Y-autosome translocations, reciprocal translocations and even complex chromosomal rearrangements (Gustavsson et al, 1989;Ková cs et al, 1992;Ansari et al, 1993;Villagó mez et al, 1993;Prakash et al, 1995;Moore et al, 1998;Neal et al, 1998;Makinen et al, 2000;Basrur et al, 2001;Iannuzzi et al, 2001a, b). Like in humans, the usual deficient reproductive performance observed in translocation carriers is thought to be due to fertilisation/implantation failure or loss of embryos, resulting from fertilization with karyotypically unbalanced gametes.…”

confidence: 99%

Somatic chromosomal abnormalities in infertile men and women

Mau-Holzmann¹

2005

Cytogenet Genome Res

129

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Infertility – the inability to achieve conception or sustain a pregnancy through to live birth – is very common and affects about 15% of couples. While chromosomal or genetic abnormalities associated with azoospermia, severe oligozoospermia or primary ovarian failure were of no importance for reproduction prior to the era of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), advances in assisted reproductive techniques (ART) now enable many infertile couples to have children. These developments have raised the question of the genetic consequences of ICSI: concerns of the potential harm of the invasive procedure and concerns about the genetic risk. The infertile male and female definitely have an increased risk to carry a chromosomal abnormality. Detection of such an abnormality is of fundamental importance for the diagnosis of infertility, the following treatment, the evaluation of the risk for the future child and the appropriate management of the pregnancy to be obtained. Therefore, cytogenetic screening of both partners is mandatory prior to any type of ART. The present review is based on several surveys on male and female infertility and analyzes the types and frequencies of the different reported chromosome abnormalities according to the type of impairment of spermatogenesis and the type of treatment planned or performed. With regard to assisted reproductive techniques (especially ICSI) the main types of chromosomal abnormalities are discussed and their potential risks for ICSI. If available, reported cases of performed ICSI and its outcome are presented. The detection of an abnormal karyotype should lead to comprehensive genetic counselling, which should include all well-known information about the individual type of anomaly, its clinical relevance, its possible inheritance, the genetic risk of unbalanced offspring, and the possibilities of prenatal diagnosis. Only this proceeding allows at-risk couples to make an informed decision regarding whether or not to proceed with ART. These decisions can be made only when both partners have clearly understood the genetic risks and possible consequences when ART is used.

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“…Noreover, these actions can cause infertility if unpaired autosomes or autosomal segments are paired with the X chromosome. A clear case was shown in a cross-breed, female Limousin-Jersey studied by Basrur et al, (2001) in which chromosome 1 was associated with the inactive X chromosome.…”

Section: What Happens In the Pachytene Synapsis Of Cattle Carrier Of mentioning

confidence: 96%

Could Tissue-Specific Genes be Silenced in Cattle Carrying the Rob(1;29) Robertsonian Translocation?

Postiglioni¹,

Artigas²,

Iriarte³

et al. 2012

DNA Methylation - From Genomics to Technology

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X-autosome translocation and low fertility in a family of crossbred cattle

Cited by 19 publications

References 30 publications

Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding

Localisation of aphidicolin-induced break points in Holstein-Friesian cattle (Bos taurus) using RBG-banding

Somatic chromosomal abnormalities in infertile men and women

Could Tissue-Specific Genes be Silenced in Cattle Carrying the Rob(1;29) Robertsonian Translocation?

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