The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms

A study on co-localization of FSH and its receptor in rat hippocampus

“…Searching the Human Anatomic Gene Expression Library (H-ANGEL) online (Tanino et al 2005), the result showed that FSH b chain precursor and FSH receptor precursor are expressed in brain, including in hippocampus. These findings support our conclusions.…”

Comparative genome analyses of nervous system-specific genes

“…To define a NS-specific gene in the human genome, we used information on the gene expression of these loci. For identifying NS-specific genes, we used the iAFLP data, which include the gene expression profiles of more than 40 different human tissues are included (Imanishi et al, 2004;Tanino et al, 2005). In fact, we were able to assign amino acid sequences to 19,107 of the 21,037 loci in the H-invitational database and, further, to assign gene expression data to 11,827 of these 19,107 loci.…”

“…In fact, we were able to assign amino acid sequences to 19,107 of the 21,037 loci in the H-invitational database and, further, to assign gene expression data to 11,827 of these 19,107 loci. In the iAFLP data, Tanino et al (2005) classified the 40 human tissues into 10 categories: neural, blood/ spleen/LND, dermal connective, placenta/testis/ovary, muscle/ heart, stomach/colon, liver, lung, kidney/bladder, and endocrine/exocrine. We then defined 'NS-specific genes' as those loci that showed more than 50% of their total gene expression in tissue of the 'neural' category.…”

Investigation of protein functions through data-mining on integrated human transcriptome database, H-Invitational database (H-InvDB)

“…The H-ANGEL database comprises the largest and most comprehensive collection of gene expression patterns thus far, which also provides a classification of human genes in terms of expression (Tanino et al, 2005). A sample view of H-ANGEL is shown in Fig.…”

“…3D. We collected gene expression data in normal and adult human tissues that were generated by three types of methods and in seven different platforms, including: iAFLP, a PCR-based quantitative expression profiling method; DNA arrays (long oligomers, short oligomers and cDNA microarrays; and cDNA sequence tags (SAGE, EST and MPSS) (Tanino et al, 2005). By normalizing levels of gene expression in experiments conducted with different methods, we determined gene expression patterns of 18,897 H-Inv loci and identified 968 H-Inv loci that are expressed in a tissuespecific manner in the 10 tissue categories.…”