The host response in secondary hydatidosis of mice

Araj, George F.; Matossian, R. M.; Malakian, Artin

doi:10.1007/bf00380556

Cited by 19 publications

(11 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If no sand is present, the cyst is sterile and does not form secondary cysts in case of spillage. It takes 6–9 months for a cyst to become fertile [56]. This delay is important to keep in mind.…”

Section: Discussionmentioning

confidence: 99%

Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature

et al. 2012

View full text Add to dashboard Cite

Primary intradural extramedullary hydatid cyst is a rare form of parasitic infection, causing focal neurological signs, commonly observed in sheep-raising areas of the world. We report a rare case of intradural, extramedullary spinal cyst, which we had misdiagnosis in the first surgery, because of rarity of the case. A 55-year-old man presented to our hospital in August 2008. He was admitted to our clinic because of lumbar pain of increasing severity and progressive difficulty with walking and stiffness of both lower limbs, which had lasted for 1 month. On the basis of imaging results, arachnoid cyst of the lumbar spine was diagnosed. Due to rapid progression of the patient’s symptoms toward spastic paraplegia, he underwent an emergency surgical decompression procedure. The patient underwent exploratory surgery using a posterior approach. A L1–L2 laminectomy was performed. After opening the dura, an intradural extramedullary cystic mass was determined. The surgical specimen measured 6 × 2 cm and was described as a whitish, pearl-like, semitranslucent, cystic material, which was thought to be parasitic. Surgery has to be followed by albendazole therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature

et al. 2012

View full text Add to dashboard Cite

show abstract

“…A group of Balb/c mice ( n = 20) was inoculated intraperitoneally according to Araj et al . (1977) with 200 μl of a suspension containing 2000 viable protoscoleces in PBS.…”

Section: Methodsmentioning

confidence: 99%

Modulation of the cellular immune response by a carbohydrate rich fraction from Echinococcus granulosus protoscoleces in infected or immunized Balb/c mice

Dematteis

Pirotto

Marques

et al. 2001

Parasite Immunology

View full text Add to dashboard Cite

Infection of Balb/c mice with Echinococcus granulosus protoscoleces constitutes the model for secondary hydatid infection. The immune response of Balb/c mice infected with E. granulosus is characterized by secretion of antibodies specific for carbohydrate epitopes and production of type-2 cytokines. A role for glycoconjugates in the induction of type-2 responses has been suggested in other host--parasite systems. Although glycoconjugates are immunogenic in E. granulosus infection, the role of these molecules in the establishment of the type-2 response has never been analysed. In this study, a carbohydrate rich fraction (E4+) from E. granulosus protoscoleces was obtained using the monoclonal antibody E492/G1 specific for the moiety Galalpha(1,4)Gal which is widely represented in protoscoleces and other E. granulosus antigenic preparations. The results showed that E4+ was immunogenic in Balb/c mice evoking an antibody response mainly directed against carbohydrate epitopes. In addition, splenocytes from E4+-immunized mice showed suppressed proliferative responses to Con A and E4+ induced IL-10 secretion by E4+-primed and naive splenocytes. The fraction E4+ also was immunogenic in infected mice during early infection. In this case also, splenocytes from infected mice as well as peritoneal cells from infected or naive mice, when stimulated in vitro with E4+, secreted IL-10. Collectively, these results suggest that E4+ may be involved in immunosuppression phenomena and, by stimulating IL-10 secretion, may contribute to the induction and sustaining of the type-2 cytokine response established in early experimental infection.

show abstract

“…A shift to a Th1-type response was observed 4 weeks post infection with a significant increase of IFNc secretion. The very early Th2-polarization induced by live protoscoleces was lost after four weeks of infection that is at the time where cysts are expected to develop (Araj et al 1977).…”

Section: Discussionmentioning

confidence: 99%

“…Parasite vitality was determined by eosin exclusion (Robinson and Arme 1985). Mice were inoculated intra-peritonealy with 200 ll of a suspension containing 2000 live protoscoleces in PBS (Araj et al 1977;Dematteis et al 1999). …”

Section: Parasite and Infectionmentioning

confidence: 99%

Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice

2014

View full text Add to dashboard Cite

The current study was carried out to evaluate the prophylactic and therapeutic effects of Allium sativum on experimental cystic echinococcosis by measuring the serum nitric oxide level and studying hepatic histopathological changes. The experimental animals were divided into five groups, ten mice in each, group (I): prophylactic; group (II): therapeutic; group (III): prophylactic and therapeutic; group (IV): infected nontreated; group (V): non infected non treated. The results showed that serum nitric oxide was significantly increased as a result of infection in all infected groups compared to group V. Statistical significant difference was noted in serum nitrate level in group

show abstract

The host response in secondary hydatidosis of mice

Cited by 19 publications

References 8 publications

Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature

Intradural extramedullary primary hydatid cyst of the spine: a case report and review of literature

Modulation of the cellular immune response by a carbohydrate rich fraction from Echinococcus granulosus protoscoleces in infected or immunized Balb/c mice

Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice

Contact Info

Product

Resources

About