Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice

Ali, Nematallah; Ibrahim, Amr M.; Ahmed, Noha

doi:10.1007/s12639-014-0600-x

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…Surgery is the method of choice for treating hydatid disease [19]. However, one study [10] reported that albendazole resulted in successful treatment in 49.3% of patients, partially successful treatment in 13.1%, improvement in 5.9%, and failure in 31.5% of patients.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Treatment in Children with Hydatid Cyst of the Liver

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Laparoscopic Treatment in Children with Hydatid Cyst of the Liver

et al. 2017

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“…The Griess reaction is based on two steps of diazotization reaction in which acidified NO2 -produces a nitrosating agent that reacts with sulfanilic acid to produce the diazonium ion. This ion is then coupled to N-(1-naphthyl) ethylenediamine to form the chromophoric azo-derivative which absorbs light at 540-570 nm according to nitric oxide assay kit (colorimetric) [21] at www.abcam.com (Version 7b Last Updated 9 August 2017).…”

Section: Assessment Of Drugs Efficacy Estimation Of Nomentioning

confidence: 99%

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Kishik

Nagati

Hayawan

et al. 2020

Parasitologists United Journal

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Background: Cystic echinococcosis is a frequent worldwide disease. Surgery is the main policy of treatment. The benzimidazoles are the drugs of choice as adjuvant therapy besides surgery, but they have some drawbacks, so there is a pressing need to develop other safe and cheap drugs such as an herbal extract. Objectives: To increase the efficacy of Nigella sativa oil (NSO) administered either as monotherapy or combined with albendazole, and using chitosan nanoparticles as a drug delivery system for both drugs. Material and Methods: E. granulosus protoscoleces were obtained by aseptic puncture of hydatid cysts. Mice infected by intraperitoneal inoculation with nearly 1000 protoscoleces per mouse were subdivided into 7 groups: G2, infected non-treated; G3, treated with albendazole; G4, treated with NSO; G5, treated with NSO and albendazole; G6, treated with albendazole loaded on chitosan nanoparticles; G7, treated with NSO loaded on chitosan nanoparticles; G8, treated with albendazole and NSO loaded on chitosan nanoparticles. G1 included the non-infected, non-treated control mice. Serum was collected for biochemical and serological assay. NO was measured according to nitric oxide assay colorimetric kit. The systemic level of TNF-α and IL-5 was determined in the plasma of mice using commercial enzyme-linked immunosorbent assay kits. Results: The results revealed that a significant increase of IL-5 occurred in all treated groups to reach the highest value in G8. There was a significant decrease of TNF-α in all treated groups in comparison to G1 and G2 (P<0.001). Mean level of nitric oxide (NO) was significantly increased in groups loaded on chitosan nanoparticles in comparison to G2. Conclusion: Nigella sativa oil showed a promising effect on CE when used alone or in combination with albendazole and its effect was augmented when loaded on chitosan nanoparticles.Nanotechnology and treatment of echinoncoccosis Kishik et al.,

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“…In recent years, garlic functional ingredients have become a hot topic in the research of medical research institutions in many countries [1][2][3]. In developed countries such as the United States, garlic pharmaceutical products tend to replace antibiotic products [4][5][6]. China is the world's largest garlic grower, accounting for more than 60% of the world's sown area and about 70% of the world's output.…”

Section: Introductionmentioning

confidence: 99%

Design and Experimental Study of Spoon-Clamping Type Garlic Precision Seeding Device

Zhang

Tao

et al. 2022

Wireless Communications and Mobile Computing

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In order to realize the mechanized sowing operation of garlic and ensure that the position of garlic scales is planted upright-position, a spoon-clamping type garlic precision seeding device is designed. The device is composed of seed box, seeder, righting fittings, and so on. This paper adopts the method of theoretical analysis; combined with the characteristics of garlic, the key components of the sowing device have been optimized and designed; and the final form of the device is determined. The one-factor experiment and multifactor experimental studies were carried out, and the optimal working parameter combination of the device was obtained by using the response surface methodology and mathematical modeling method, and finally, the optimized working parameter combination was verified. The results showed that the spoon-clamping type garlic sowing device could meet the operational requirements of garlic mechanized sowing. This study has certain theoretical and practical significance for the mechanization development of garlic.

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Assessment of the effect of Allium sativum on serum nitric oxide level and hepatic histopathology in experimental cystic echinococcosis in mice

Cited by 9 publications

References 29 publications

Laparoscopic Treatment in Children with Hydatid Cyst of the Liver

Laparoscopic Treatment in Children with Hydatid Cyst of the Liver

Efficacy of Nigella sativa oil and its chitosan loaded nanoparticles on experimental cystic echinoncoccosis with immunological assessment

Design and Experimental Study of Spoon-Clamping Type Garlic Precision Seeding Device

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