The hormesis effect of plasma-elevated intracellular ROS on HaCaT cells

Szili, Endre J.; Harding, Frances J.; Hong, Sung-Ha; Herrmann, Franziska; Voelcker, Nicolas H.; Short, Robert D.

doi:10.1088/0022-3727/48/49/495401

Cited by 20 publications

(27 citation statements)

References 82 publications

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“…We hypothesize that the product of treatment time and flow rate might be a determining factor rather than the individual parameters. Indeed, extracellular ROS has been shown to increase in function of treatment time and flow rate . In addition, Cheng et al include the output voltage in this equation to calculate plasma dosage …”

Section: Resultscontrasting

confidence: 96%

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Cold atmospheric plasma treatment of melanoma and glioblastoma cancer cells

Vermeylen¹,

Waele²,

Vanuytsel

et al. 2016

Plasma Processes & Polymers

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In this paper, two types of melanoma and glioblastoma cancer cell lines are treated with cold atmospheric plasma to assess the effect of several parameters on the cell viability. The cell viability decreases with treatment duration and time until analysis in all cell lines with varying sensitivity. The majority of dead cells stains both AnnexinV (AnnV) and propidium iodide, indicating that the plasma‐treated non‐viable cells are mostly late apoptotic or necrotic. Genetic mutations might be involved in the response to plasma. Comparing the effects of two gas mixtures, as well as indirect plasma‐activated medium versus direct treatment, gives different results per cell line. In conclusion, this study confirms the potential of plasma for cancer therapy and emphasizes the influence of experimental parameters on therapeutic outcome.

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Section: Resultscontrasting

confidence: 96%

“…To this end, we will examine proliferation rate in future experiments as well. Moreover, plasma has been shown to alter proliferative behavior …”

Section: Resultssupporting

confidence: 91%

Cold atmospheric plasma treatment of melanoma and glioblastoma cancer cells

Vermeylen¹,

Waele²,

Vanuytsel

et al. 2016

Plasma Processes & Polymers

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“…chronic wounds and cancers. It has been shown through in vitro cell studies and in vivo animal experiments that cold atmospheric plasma, herein referred to as plasma, might accelerate wound healing by stimulation of cell growth and migration [1][2][3][4][5][6][7][8][9][10][11], and also decontaminate infected wounds through targeted destruction of bacterial cells [12][13][14][15][16][17][18][19][20][21][22]. Similar results have been obtained in clinical studies where the efficacy of plasma in wound decontamination and healing has been demonstrated [23][24][25][26].…”

Section: Introductionsupporting

confidence: 55%

The assessment of cold atmospheric plasma treatment of DNA in synthetic models of tissue fluid, tissue and cells

Szili

Gaur

Hong

et al. 2017

J. Phys. D: Appl. Phys.

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“…This preliminary small catalogue of questions can be easily extended considering the findings and future prospects of redox biology, both in view of basic research and with respect to specific pathologies (178). Finally, yet importantly, the concept of oxidative eustress and distress and its possible controllability by CAP treatment can also serve for further basic research on the "hormesis" phenomenon, which has received increased attention in recent years (176,(179)(180)(181)(182).…”

Section: Discussionmentioning

confidence: 99%