The horizon: New targets and new agents†

Jazwinski, M.H.S. and Alison B.; Muir, Margaret

doi:10.1002/cld.2

Cited by 1 publication

(1 citation statement)

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“…However, there was no other documented HCV transmission in the cohort. The recent approval of direct‐acting agents, well tolerated, safe and highly effective, to treat HCV infections may modify the post‐transplant outcome of the recipients who received organs from anti‐HCV/HCV‐RNA‐positive donors and policies regarding the use of organs from HCV donors should be reconsidered .…”

Section: Discussioncontrasting

confidence: 44%

Organ transplantation from “increased infectious risk donors”: the experience of the Nord Italia Transplant program - A retrospective study

et al. 2017

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The purpose of this study was to assess the safety and the clinical outcome associated with organ transplantation from increased infectious risk donors (IRD). We retrospectively identified all adult deceased IRD referred to the Nord Italia Transplant program coordinating center from November 2006 to November 2011. All potential donors were screened for social risk factors that may increase the risk of donor-derived infection with human immunodeficiency (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). All recipients were followed monthly for the first 6 months post-transplant. A total of 86 potential IRD were identified during the study period. Three hundred and seventy-nine organs from IRD were offered to the transplant centers, but only 185 (48.8%) were used for transplantation. Organs from IRD were transplanted into 174 recipients. The complete follow-up data were available for 152 of 174 (87.3%) recipients. During a mean follow-up of 11.7 months (median 12; range 2.4-12), no transmission of HIV, HBV, or syphilis was documented by serology and nucleic acid testing (NAT) testing. Two patients transplanted with organs from HCV-RNA-positive donors, as expected, developed post-transplant HCV infection. In conclusion, the use of organs from IRD was associated with a safe increase in the transplant procedures in our country.

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Section: Discussioncontrasting

confidence: 44%